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Protein
Submitted name:

Estrogen receptor beta

Gene

ESR2

Organism
Ovis aries (Sheep)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi143 – 218Nuclear receptorPROSITE-ProRule annotationAdd BLAST76

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotationSAAS annotation, ReceptorUniRule annotationSAAS annotation
Biological processTranscription, Transcription regulationUniRule annotationSAAS annotation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Estrogen receptor betaImported
Gene namesi
Name:ESR2Imported
OrganismiOvis aries (Sheep)Imported
Taxonomic identifieri9940 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
Proteomesi
  • UP000002356 Componenti: Chromosome 7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini143 – 218Nuclear receptorInterPro annotationAdd BLAST76
Domaini261 – 495NR LBDInterPro annotationAdd BLAST235

Sequence similaritiesi

Belongs to the nuclear hormone receptor family. NR3 subfamily.UniRule annotation

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118887
OMAiEPQKSPW
OrthoDBiEOG091G03V4

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR028355 ER-beta/gamma
IPR021064 Estrogen_rcpt_beta_N
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR024178 Oest_rcpt/oest-rel_rcp
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF12497 ERbeta_N, 1 hit
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit
PIRSFiPIRSF500102 ER-b, 1 hit
PIRSF002527 ER-like_NR, 1 hit
PRINTSiPR00398 STRDHORMONER
PR00047 STROIDFINGER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequencei

Sequence statusi: Complete.

W5QJ29-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVKNSPSSL NSPVSYNCGQ SILPLEPGPI YLPSSYVESR HEYSAVTFYS
60 70 80 90 100
PAVMNYSIPN NSEDGPGRQT TSPNVLWPTP GHLSPLAIHC QSSLLYAEPQ
110 120 130 140 150
KSPWCETRSL EHTFPVNRET LKRKASGSSC ASPVSSPSSK RDAHFCAVCS
160 170 180 190 200
DYASGYHYGV WSCEGCKAFF KRSIQGHNDY ICPATNQCTI DKNRRKSCQA
210 220 230 240 250
CRLRKCYEVG MVKCGSRRER CGYRIVRRQR NSDEQLHCLS KTKRNGAPMT
260 270 280 290 300
RVKELLLSAL SPEQLVLTLL EAEPPHVLMS RPSAPFTEAS MMMSLTKLAD
310 320 330 340 350
KELVHMISWA KKIPGFVELS LYDQVRLLES CWLEVLMVGL MWRSIDHPGK
360 370 380 390 400
LIFAPDLVLD RDEGKCVEGI LEIFDMLLAT TSRFRELKLQ HKEYLCVKAM
410 420 430 440 450
ILLNSSMYPS ATAPQEADSG RKLTHLLNAV TDALVWVIAK SGMSSQQQSM
460 470 480 490 500
RLANLLMLLS HVRHASNKGM EHLLNMKCKN VVPVYDLLLE MLNAHTLRSN
510 520
KPLVTRSERN LAEDSESKEG SQKPQAQ
Length:527
Mass (Da):59,130
Last modified:April 16, 2014 - v1
Checksum:iACD6EACE4FFA5B33
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AMGL01104204 Genomic DNA No translation available.
AMGL01104205 Genomic DNA No translation available.
RefSeqiXP_012035989.1, XM_012180599.2
XP_014952172.1, XM_015096686.1
UniGeneiOar.651

Genome annotation databases

EnsembliENSOART00000023044; ENSOARP00000022731; ENSOARG00000021148
GeneIDi443066

Similar proteinsi

Entry informationi

Entry nameiW5QJ29_SHEEP
AccessioniPrimary (citable) accession number: W5QJ29
Entry historyiIntegrated into UniProtKB/TrEMBL: April 16, 2014
Last sequence update: April 16, 2014
Last modified: July 18, 2018
This is version 38 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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