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Protein

DNA polymerase

Gene

POLA1

Organism
Ovis aries (Sheep)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).UniRule annotation

Cofactori

[4Fe-4S] clusterUniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingUniRule annotation, DNA-directed DNA polymeraseUniRule annotation, Nucleotidyltransferase, Transferase
Biological processDNA replicationUniRule annotation
Ligand4Fe-4SUniRule annotation, Iron, Iron-sulfur, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymeraseUniRule annotation (EC:2.7.7.7UniRule annotation)
Gene namesi
Name:POLA1Imported
OrganismiOvis aries (Sheep)Imported
Taxonomic identifieri9940 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
Proteomesi
  • UP000002356 Componenti: Chromosome X

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

Expressioni

Gene expression databases

ExpressionAtlasiW5Q828 baseline

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 102DNA_pol_alpha_NInterPro annotationAdd BLAST62
Domaini377 – 716DNA_pol_B_exo1InterPro annotationAdd BLAST340
Domaini774 – 1233DNA_pol_BInterPro annotationAdd BLAST460
Domaini1272 – 1461zf-DNA_PolInterPro annotationAdd BLAST190

Sequence similaritiesi

Belongs to the DNA polymerase type-B family.UniRule annotation

Keywords - Domaini

Zinc-fingerUniRule annotation

Phylogenomic databases

GeneTreeiENSGT00550000074891
KOiK02320
OMAiPKDCIFP
OrthoDBiEOG091G00RR

Family and domain databases

Gene3Di1.10.3200.20, 1 hit
3.30.420.10, 1 hit
3.90.1600.10, 1 hit
InterProiView protein in InterPro
IPR006172 DNA-dir_DNA_pol_B
IPR017964 DNA-dir_DNA_pol_B_CS
IPR006133 DNA-dir_DNA_pol_B_exonuc
IPR006134 DNA-dir_DNA_pol_B_multi_dom
IPR024647 DNA_pol_a_cat_su_N
IPR023211 DNA_pol_palm_dom_sf
IPR038256 Pol_alpha_znc_sf
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
IPR015088 Znf_DNA-dir_DNA_pol_B_alpha
PfamiView protein in Pfam
PF12254 DNA_pol_alpha_N, 1 hit
PF00136 DNA_pol_B, 1 hit
PF03104 DNA_pol_B_exo1, 1 hit
PF08996 zf-DNA_Pol, 1 hit
PRINTSiPR00106 DNAPOLB
SMARTiView protein in SMART
SM00486 POLBc, 1 hit
SUPFAMiSSF53098 SSF53098, 1 hit
PROSITEiView protein in PROSITE
PS00116 DNA_POLYMERASE_B, 1 hit

Sequencei

Sequence statusi: Complete.

W5Q828-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPLHGEDCE PGANAVSDSR NFVASRSRRE KKSKKGRQEA LERLKRAKAG
60 70 80 90 100
EKCKYEVEDF TSVYEEVDEE QYSKLVQARQ DDDWIVDDDG IGYVEDGREI
110 120 130 140 150
FDDDLEDDAL DSHEKGKDDK ACNKDKRTVK RAAVTKPNNI KSMFIANAGR
160 170 180 190 200
KTVDKAVDLS KDDLLGDILQ DLNTETPQIT PPPVIIPKKK RSSGASLNPF
210 220 230 240 250
SVHTPKAAPS GKTTPSASRK EPSLTPASLT CAEFAGEPRP PLCTDDKEES
260 270 280 290 300
GAMEFEDGDF DEPMEAEEVD VEPVAAKTLC QEREPAEEAK QKADSGKGTA
310 320 330 340 350
SSSASFLPDV SCWDMDQEDD SSFSAPEVQV DSSHLPLVKG ADEEQVFQFY
360 370 380 390 400
WLDAYEDPYS QPGVVFLFGK VWIESAETHV SCCVMVKNIE RTLCFLPREM
410 420 430 440 450
KVDLNTGKES GTPVTMKDVY DEFDEKIAAK YKIMKFKSKV VEKNYAFEIP
460 470 480 490 500
DVPEKSEYLE VRYSAEMPQL PQDLKGETFS HVFGTNTSSL ELFLMNRKIK
510 520 530 540 550
GPCWLEVKNP QLLNQPISWC KVEAMVLKPD LVNVIKDVGP PPVVVMSLSM
560 570 580 590 600
KTMQNAKTHE NEIIAVSALV HHSFALDKAP PQPPFQSHFC VVSKPKDCIF
610 620 630 640 650
PYDFKESIKE KNVKVEVAAT ERTLLGCFLA KVHKIDPDII VGHNIYGFEL
660 670 680 690 700
EVLLQRINVC KVPFWSKIGR LKRSNMPKLG GRSGFGEKNA TCGRMICDVE
710 720 730 740 750
ISAKELIRCK SYHLSELVQQ ILKTERIVIP IENIRNMYSD SSHLLYLLEH
760 770 780 790 800
TWKDARFILQ IMCELNVLPL ALQITNIAGN IMSRTLMGGR SERNEFLLLH
810 820 830 840 850
AFYENNYIVP DKQTFRKPQQ KLGDEDEDID GDTNKYKKGR KKAAYSGGLV
860 870 880 890 900
LDPKVGFYDK FILLLDFNSL YPSIIQEFNI CFTTVQRVAS EAQKVVEDGE
910 920 930 940 950
QEQIPELPDP SLEMGILPRE IRKLVERRRQ VKQLMKQQDL NPDLHLQYDI
960 970 980 990 1000
RQKALKLTAN SMYGCLGFSY SRFYAKPLAA LVTYKGREIL MHTKEMVQKM
1010 1020 1030 1040 1050
NLEVIYGDTD SIMINTNSTN LEEVFKLGNK VKSEVNKLYK LLEIDIDGIF
1060 1070 1080 1090 1100
KSLLLLKKKK YAALIVEPTS DGNYVTKQEV KGLDIVRRDW CDLAKDTGNF
1110 1120 1130 1140 1150
VIGQILSDQN RDTIVENIQK RLIEIGENVL NGSVPVSQFE INKALTKDPQ
1160 1170 1180 1190 1200
DYPDKKSLPH VHVALWINSQ GGRKVKAGDT VSYVICQDGS NLTAGQRAYA
1210 1220 1230 1240 1250
PEQLQKQDNL SIDTQYYLAQ QIHPVVARIC EPIDGIDAIL IASWLGLDPT
1260 1270 1280 1290 1300
QFRVHHYHKD EENDALLGGP AHLTDEEKYK DCERFKCPCP TCGTENIYDS
1310 1320 1330 1340 1350
VFDGSGTDME PSLYRCSNIN CKASPLTFMV QLSNKLIMDI RRCIKKYYEG
1360 1370 1380 1390 1400
WLICEEPTCR NRTRHLPLQF SRNGPLCQVC MKATLRLEYS DKSLYTQLCF
1410 1420 1430 1440 1450
YRYIFDVECA LEKLITDHEK DKLKKQFLTP KVLQDYRKLK NTAEQFLSQS
1460
GYSKVNLSRL FADCAVWS
Length:1,468
Mass (Da):166,502
Last modified:April 16, 2014 - v1
Checksum:iEA661650B1D2FE41
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AMGL01114240 Genomic DNA No translation available.
AMGL01114241 Genomic DNA No translation available.
AMGL01114242 Genomic DNA No translation available.
AMGL01114243 Genomic DNA No translation available.
AMGL01114244 Genomic DNA No translation available.
RefSeqiXP_011961813.1, XM_012106423.2

Genome annotation databases

EnsembliENSOART00000019137; ENSOARP00000018870; ENSOARG00000017574
GeneIDi101115602
KEGGioas:101115602

Similar proteinsi

Entry informationi

Entry nameiW5Q828_SHEEP
AccessioniPrimary (citable) accession number: W5Q828
Entry historyiIntegrated into UniProtKB/TrEMBL: April 16, 2014
Last sequence update: April 16, 2014
Last modified: April 25, 2018
This is version 29 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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