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Entry version 44 (02 Jun 2021)
Sequence version 1 (16 Apr 2014)
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Protein

Alpha-dystroglycan

Gene

DAG1

Organism
Ovis aries (Sheep)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization.

ARBA annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Protein family/group databases

MEROPS protease database

More...
MEROPSi
S72.001

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Alpha-dystroglycanARBA annotation
Alternative name(s):
Beta-dystroglycanARBA annotation
DystroglycanARBA annotation
Dystrophin-associated glycoprotein 1ARBA annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DAG1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiOvis aries (Sheep)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9940 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaArtiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002356 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei754 – 780HelicalSequence analysisAdd BLAST27

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction, Cell membraneARBA annotation, Cytoplasm, CytoskeletonARBA annotation, Membrane, NucleusARBA annotation, Postsynaptic cell membraneARBA annotation, SecretedARBA annotation, Synapse

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 27Sequence analysisAdd BLAST27
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500486993528 – 900Alpha-dystroglycanSequence analysisAdd BLAST873

Keywords - PTMi

Disulfide bondARBA annotation, GlycoproteinARBA annotation, PhosphoproteinARBA annotation

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
122, 7 O-Linked glycans

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9940.ENSOARP00000014632

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
W5PVZ9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini608 – 717Peptidase S72InterPro annotationAdd BLAST110

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni381 – 505DisorderedSequence analysisAdd BLAST125
Regioni728 – 751DisorderedSequence analysisAdd BLAST24
Regioni828 – 900DisorderedSequence analysisAdd BLAST73

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi381 – 403Polar residuesSequence analysisAdd BLAST23
Compositional biasi473 – 495Polar residuesSequence analysisAdd BLAST23
Compositional biasi737 – 751Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi863 – 878Pro residuesSequence analysisAdd BLAST16

Keywords - Domaini

SignalSequence analysisARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3781, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_007629_2_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
YDKEDTT

Database of Orthologous Groups

More...
OrthoDBi
163609at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 2 hits
3.30.70.1040, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027468, Alpha-dystroglycan_domain_2
IPR041631, Alpha_DG1_N2
IPR006644, Cadg
IPR015919, Cadherin-like_sf
IPR008465, DAG1_C
IPR013783, Ig-like_fold
IPR030398, SEA_DG_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF18424, a_DG1_N2, 1 hit
PF05454, DAG1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00736, CADG, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF111006, SSF111006, 1 hit
SSF49313, SSF49313, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51699, SEA_DG, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

W5PVZ9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRMSVGPSLW LPLWGRTFLL LLSVAMAQSH WPSEPSEAAR DWENQLEASM
60 70 80 90 100
HSALSDLHEA VPTVVGIPDG TAVVGRSFRV TIPTDLIASN GEVIKVSAAG
110 120 130 140 150
KEALPSWLHW DPRSHTLEGL PLDTDKGVHY ISVSAARLGA NGSHVPQTSS
160 170 180 190 200
VFSIEVYPED HSEPQSLRAA SPDPGEVVSS VCAADEPVTV LTVILDADLT
210 220 230 240 250
KMTPKQRIDL LRRMRGFSEV EPHNMKLVPV VNNRLFDMSA FMAGPGNAKK
260 270 280 290 300
VVENGALLSW KLGCALNQNS VPDIRGVEVP AREGAMSAQL GYPVVGWHIA
310 320 330 340 350
NKKPPLPKRI RRQIHATPTP VTAIGPPTTA IQEPPSRIVP TPTSPAIAPP
360 370 380 390 400
TETMAPPVRD PVPGKPTVTI RTRGAIVQTP TLGPIQPTRV SEAGTTVPSQ
410 420 430 440 450
IRPTMTIPGY VEPTAVITPP TMTTRKPRVS TPRVPPPRPA TPSTDSSTAT
460 470 480 490 500
TRRPTKKPRT SRPVPRVTTK APITRLETAS PPTRIRTTTS GVPHGREPNQ
510 520 530 540 550
GPELKNHIDR VDAWVGTYFE VKIPSDTFYD NEDTTTDKLK LTLKLREQQL
560 570 580 590 600
VGEKSWVQFN SNSQLMYGLP DSSHVGKHEY FMHATDKGGL SAVDAFEIHV
610 620 630 640 650
HRRPQGDKAP ARFKAKLTGD PAAVTNDIHK KIALVKKLAF AFGDRNCSTI
660 670 680 690 700
TLQNITRGSI VVEWTNNTLP LEPCPKEQIT ALSRRIAEDD GKPRAAFVNA
710 720 730 740 750
LEPDFQAMSI TVTGSGSCRH LQFVPAAPPR RVPSEAPATE VPDRDPERSS
760 770 780 790 800
EDDVYLHTVI PAVVVAAILL IAGIIAMICY RKKRKGKLTL EDQATFIKKG
810 820 830 840 850
VPIIFADELD DSKPPPSSSM PLILQEEKAP LPPPEYPNQS VPETTPLNQD
860 870 880 890 900
TVGEYAPLRD EDPSAPPYQP PPPFTAPMEG KGSRPKNMTP YRSPPPYVPP
Length:900
Mass (Da):97,914
Last modified:April 16, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBFB45BAB103407C7
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AMGL01045647 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_004018507.1, XM_004018458.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSOART00000014847; ENSOARP00000014632; ENSOARG00000013645

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
101103515

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
oas:101103515

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AMGL01045647 Genomic DNA No translation available.
RefSeqiXP_004018507.1, XM_004018458.3

3D structure databases

SMRiW5PVZ9
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9940.ENSOARP00000014632

Protein family/group databases

MEROPSiS72.001

PTM databases

GlyConnecti122, 7 O-Linked glycans

Genome annotation databases

EnsembliENSOART00000014847; ENSOARP00000014632; ENSOARG00000013645
GeneIDi101103515
KEGGioas:101103515

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1605

Phylogenomic databases

eggNOGiKOG3781, Eukaryota
HOGENOMiCLU_007629_2_0_1
OMAiYDKEDTT
OrthoDBi163609at2759

Family and domain databases

Gene3Di2.60.40.10, 2 hits
3.30.70.1040, 1 hit
InterProiView protein in InterPro
IPR027468, Alpha-dystroglycan_domain_2
IPR041631, Alpha_DG1_N2
IPR006644, Cadg
IPR015919, Cadherin-like_sf
IPR008465, DAG1_C
IPR013783, Ig-like_fold
IPR030398, SEA_DG_dom
PfamiView protein in Pfam
PF18424, a_DG1_N2, 1 hit
PF05454, DAG1, 1 hit
SMARTiView protein in SMART
SM00736, CADG, 2 hits
SUPFAMiSSF111006, SSF111006, 1 hit
SSF49313, SSF49313, 2 hits
PROSITEiView protein in PROSITE
PS51699, SEA_DG, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiW5PVZ9_SHEEP
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: W5PVZ9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 16, 2014
Last sequence update: April 16, 2014
Last modified: June 2, 2021
This is version 44 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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