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Protein

Claudin

Gene

CLDN9

Organism
Ovis aries (Sheep)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
ClaudinUniRule annotation
Gene namesi
Name:CLDN9Imported
OrganismiOvis aries (Sheep)Imported
Taxonomic identifieri9940 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
Proteomesi
  • UP000002356 Componenti: Chromosome 24

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei79 – 105HelicalUniRule annotationAdd BLAST27
Transmembranei117 – 144HelicalUniRule annotationAdd BLAST28
Transmembranei164 – 184HelicalUniRule annotationAdd BLAST21

Keywords - Cellular componenti

Cell junction, Cell membraneUniRule annotationSAAS annotation, Membrane, Tight junctionUniRule annotationSAAS annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the claudin family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118928
KOiK06087
OMAiCPPPQID
OrthoDBiEOG091G0MMR

Family and domain databases

InterProiView protein in InterPro
IPR006187 Claudin
IPR003553 Claudin9
IPR017974 Claudin_CS
IPR004031 PMP22/EMP/MP20/Claudin
PANTHERiPTHR12002 PTHR12002, 1 hit
PTHR12002:SF42 PTHR12002:SF42, 1 hit
PfamiView protein in Pfam
PF00822 PMP22_Claudin, 1 hit
PRINTSiPR01382 CLAUDIN9
PROSITEiView protein in PROSITE
PS01346 CLAUDIN, 1 hit

Sequencei

Sequence statusi: Complete.

W5PLN9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASTGLELLG MTLAVLGWLG TLVSCALPLW KVTAFIGNSI VVAQVVWEGL
60 70 80 90 100
WMSCVVQSTG QMQCKVYDSL LALPQDLQAA RALCVIALLL ALLGVLVAIT
110 120 130 140 150
GAQCTTCVED EGAKARIVLT AGVLLLLAGI LVLIPVCWTA HAIIQDFYNP
160 170 180 190 200
LVAEALKREL GASLYLGWAA SALLLLGGGL LCCTCPPPQI ERPRGPRLGY
210
SIPSRSGASG LDKRDYV
Length:217
Mass (Da):22,846
Last modified:April 16, 2014 - v1
Checksum:iCCC65C1A15C5EE2F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AMGL01068056 Genomic DNA No translation available.
RefSeqiXP_011959396.1, XM_012104006.2

Genome annotation databases

EnsembliENSOART00000011522; ENSOARP00000011362; ENSOARG00000010593
GeneIDi101117039
KEGGioas:101117039

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AMGL01068056 Genomic DNA No translation available.
RefSeqiXP_011959396.1, XM_012104006.2

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSOART00000011522; ENSOARP00000011362; ENSOARG00000010593
GeneIDi101117039
KEGGioas:101117039

Organism-specific databases

CTDi9080

Phylogenomic databases

GeneTreeiENSGT00760000118928
KOiK06087
OMAiCPPPQID
OrthoDBiEOG091G0MMR

Family and domain databases

InterProiView protein in InterPro
IPR006187 Claudin
IPR003553 Claudin9
IPR017974 Claudin_CS
IPR004031 PMP22/EMP/MP20/Claudin
PANTHERiPTHR12002 PTHR12002, 1 hit
PTHR12002:SF42 PTHR12002:SF42, 1 hit
PfamiView protein in Pfam
PF00822 PMP22_Claudin, 1 hit
PRINTSiPR01382 CLAUDIN9
PROSITEiView protein in PROSITE
PS01346 CLAUDIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiW5PLN9_SHEEP
AccessioniPrimary (citable) accession number: W5PLN9
Entry historyiIntegrated into UniProtKB/TrEMBL: April 16, 2014
Last sequence update: April 16, 2014
Last modified: November 7, 2018
This is version 33 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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