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Protein
Submitted name:

Potassium voltage-gated channel subfamily J member 12

Gene

KCNJ12

Organism
Ovis aries (Sheep)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei173Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Voltage-gated channelUniRule annotationSAAS annotation
Biological processIon transport, Potassium transportUniRule annotationSAAS annotation, Transport
LigandPotassium

Names & Taxonomyi

Protein namesi
Submitted name:
Potassium voltage-gated channel subfamily J member 12Imported
Gene namesi
Name:KCNJ12Imported
OrganismiOvis aries (Sheep)Imported
Taxonomic identifieri9940 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
Proteomesi
  • UP000002356 Componenti: Chromosome 11

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei82 – 106HelicalSequence analysisAdd BLAST25
Transmembranei157 – 182HelicalSequence analysisAdd BLAST26

Keywords - Cellular componenti

Membrane

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 46IRK_NInterPro annotationAdd BLAST44

Sequence similaritiesi

Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118842
KOiK05005
OMAiTPCVLQV
OrthoDBiEOG091G08HC

Family and domain databases

Gene3Di2.60.40.1400, 2 hits
InterProiView protein in InterPro
IPR014756 Ig_E-set
IPR016449 K_chnl_inward-rec_Kir
IPR003272 K_chnl_inward-rec_Kir2.2
IPR013518 K_chnl_inward-rec_Kir_cyto
IPR013673 K_chnl_inward-rec_Kir_N
PANTHERiPTHR11767 PTHR11767, 1 hit
PTHR11767:SF14 PTHR11767:SF14, 1 hit
PfamiView protein in Pfam
PF01007 IRK, 1 hit
PF08466 IRK_N, 1 hit
PIRSFiPIRSF005465 GIRK_kir, 1 hit
PRINTSiPR01325 KIR22CHANNEL
PR01320 KIRCHANNEL
SUPFAMiSSF81296 SSF81296, 1 hit

Sequencei

Sequence statusi: Complete.

W5P2T9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTASGRTNPY SIVSSEEDGL HLVTMSGANG FGNGKVHTRR RCRNRFVKKN
60 70 80 90 100
GQCNIEFANM DEKSQRYLAD MFTTCVDIRW RYMLLIFSLA FLASWLLFGV
110 120 130 140 150
IFWVIAVAHG DLEPAEARGR TPCVLQVHGF MAAFLFSIET QTTIGYGLRC
160 170 180 190 200
VTEECPVAVF MVVAQSIVGC IIDSFMIGAI MAKMARPKKR AQTLLFSHNA
210 220 230 240 250
VVALRDGKLC LMWRVGNLRK SHIVEAHVRA QLIKPRVTEE GEYIPLDQID
260 270 280 290 300
IDVGFDKGLD RIFLVSPITI LHEIDEASPL FGISRQDLET DDFEIVVILE
310 320 330 340 350
GMVEATAMTT QARSSYLANE ILWGHRFEPV LFEEKNQYKI DYSHFHKTYE
360 370 380 390 400
VPSTPRCSAK DLVENKFLLP STNSFCYENE LAFLSRDEED EVDGEQDSLG
410 420
PQARRDFDRP QAGTALEQRP YRRESEI
Length:427
Mass (Da):48,461
Last modified:April 16, 2014 - v1
Checksum:iE2E6DAB99EC1CBB4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AMGL01018356 Genomic DNA No translation available.
RefSeqiXP_004012795.1, XM_004012746.3
XP_012041224.1, XM_012185834.2

Genome annotation databases

EnsembliENSOART00000004820; ENSOARP00000004739; ENSOARG00000004430
GeneIDi101123388
KEGGioas:101123388

Similar proteinsi

Entry informationi

Entry nameiW5P2T9_SHEEP
AccessioniPrimary (citable) accession number: W5P2T9
Entry historyiIntegrated into UniProtKB/TrEMBL: April 16, 2014
Last sequence update: April 16, 2014
Last modified: June 20, 2018
This is version 32 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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