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Entry version 42 (11 Dec 2019)
Sequence version 1 (16 Apr 2014)
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Protein

Stonin-2

Gene

STON2

Organism
Ovis aries (Sheep)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Adapter protein involved in endocytic machinery. Involved in the synaptic vesicle recycling. May facilitate clathrin-coated vesicle uncoating.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processEndocytosisUniRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Stonin-2UniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:STON2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiOvis aries (Sheep)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9940 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaArtiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002356 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, CytoplasmUniRule annotation, Synapse, SynaptosomeUniRule annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9940.ENSOARP00000003150

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini426 – 559SHDInterPro annotationAdd BLAST134
Domaini567 – 874MHDInterPro annotationAdd BLAST308

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni10 – 128DisorderedSequence analysisAdd BLAST119
Regioni145 – 223DisorderedSequence analysisAdd BLAST79

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi38 – 55PolarSequence analysisAdd BLAST18
Compositional biasi58 – 75PolyampholyteSequence analysisAdd BLAST18
Compositional biasi145 – 192PolarSequence analysisAdd BLAST48

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Stoned B family.UniRule annotation

Phylogenomic databases

Ensembl GeneTree

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GeneTreei
ENSGT00940000159392

KEGG Orthology (KO)

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KOi
K20067

Identification of Orthologs from Complete Genome Data

More...
OMAi
WSATNPF

Database of Orthologous Groups

More...
OrthoDBi
1059322at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036168 AP2_Mu_C_sf
IPR028565 MHD
IPR012320 SHD_dom
IPR031228 STON2
IPR017110 Stonin
IPR022699 Stonin2_N

The PANTHER Classification System

More...
PANTHERi
PTHR10529:SF345 PTHR10529:SF345, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00928 Adap_comp_sub, 1 hit
PF12016 Stonin2_N, 1 hit

PIRSF; a whole-protein classification database

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PIRSFi
PIRSF037099 Stonin, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49447 SSF49447, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51072 MHD, 1 hit
PS51070 SHD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

W5NYA2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTTLDHVIAT HQSEWVSFNE EPLFPVPSEG GPKEHLPGVS SSSDQSESSS
60 70 80 90 100
GEHHALDGGS QDLSHSEHDD SSEKLGLISE AASPPGSPEQ RPPDLVSAIS
110 120 130 140 150
GWVQFEDDAP WASSSPPPKE AGGTATSLTT PCWICPSFDS LGRCPLPSES
160 170 180 190 200
SWTTHSEDTS SPSFGPSYTD LQVVSAGEQS GLASGADSTD NSSSLQEDEE
210 220 230 240 250
VEMEAISWQA GSPAMNGHPT TPVTSARFPS WVTFDDNEVS GPLSPITSPL
260 270 280 290 300
KPETLPLTSV IPDGPCNSTG SFKKRERPRS TLMNFSKVQK LDVSSVSHPP
310 320 330 340 350
AVPEAPPWRA TNPFLNETLQ DVQPSPINPF RAFFEEQERR AQNSSVSGTP
360 370 380 390 400
GKSQRDSLIV VYQDAISFDD SSRNQSRSDA VEKLKRLQIE DSDHFGGGTL
410 420 430 440 450
PDDDPAAWAE LDAHPAGSEQ SPPRDGWPMM LRIPEKKNIM SSRHWGPIYV
460 470 480 490 500
KLTDGGYLQL YYEQGLERPF REFKLEMCHE ISEPRLQNYD ENGRIHSLRI
510 520 530 540 550
DRVTYKEKKK YQPKPAVAHL AEREQVIKLG TTNYEDFLSF IRAVQDRLME
560 570 580 590 600
LPVLSTELST VGLNYLEEEM TVDVQDEFSG LVSKGDNQIL QHSVLTRIHV
610 620 630 640 650
LSFLSGLAEC RLGLNDVLVK GNEVVSRQDI VPTTTAKWIR LHECRFHGCV
660 670 680 690 700
DEDVFRGSRV ILFNPLDACR FELMRFRTVF AEKTLPFTLR TAASIHGAEV
710 720 730 740 750
EVQSWLRMSA GFSSNWDPLT QVPCENVMVR YPVPSEWVKN FRRESVLGEK
760 770 780 790 800
SLKAKVNRGA SFGSASVSGS EPVMRVTLGT AKYEHAFNAI VWRINRLPDK
810 820 830 840 850
NSASGHPHCF FCHLELGSDR EVPSRFANHV NVEFSMPTTS ASKAAVRSIS
860 870 880 890
VEDKTDVRKW VNYSAHYSYK VEIEQKKSLK LDLDGDNMEN PKECGVQ
Length:897
Mass (Da):99,492
Last modified:April 16, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCA678B160DA7E8C2
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AMGL01104767 Genomic DNA No translation available.
AMGL01104768 Genomic DNA No translation available.
AMGL01104769 Genomic DNA No translation available.
AMGL01104770 Genomic DNA No translation available.
AMGL01104771 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_004010875.1, XM_004010826.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSOART00000003210; ENSOARP00000003150; ENSOARG00000002960

Database of genes from NCBI RefSeq genomes

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GeneIDi
101117080

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
oas:101117080

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AMGL01104767 Genomic DNA No translation available.
AMGL01104768 Genomic DNA No translation available.
AMGL01104769 Genomic DNA No translation available.
AMGL01104770 Genomic DNA No translation available.
AMGL01104771 Genomic DNA No translation available.
RefSeqiXP_004010875.1, XM_004010826.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9940.ENSOARP00000003150

Genome annotation databases

EnsembliENSOART00000003210; ENSOARP00000003150; ENSOARG00000002960
GeneIDi101117080
KEGGioas:101117080

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
85439

Phylogenomic databases

GeneTreeiENSGT00940000159392
KOiK20067
OMAiWSATNPF
OrthoDBi1059322at2759

Family and domain databases

InterProiView protein in InterPro
IPR036168 AP2_Mu_C_sf
IPR028565 MHD
IPR012320 SHD_dom
IPR031228 STON2
IPR017110 Stonin
IPR022699 Stonin2_N
PANTHERiPTHR10529:SF345 PTHR10529:SF345, 1 hit
PfamiView protein in Pfam
PF00928 Adap_comp_sub, 1 hit
PF12016 Stonin2_N, 1 hit
PIRSFiPIRSF037099 Stonin, 1 hit
SUPFAMiSSF49447 SSF49447, 1 hit
PROSITEiView protein in PROSITE
PS51072 MHD, 1 hit
PS51070 SHD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiW5NYA2_SHEEP
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: W5NYA2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 16, 2014
Last sequence update: April 16, 2014
Last modified: December 11, 2019
This is version 42 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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