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Protein
Submitted name:

Solute carrier family 25 member 12

Gene

SLC25A12

Organism
Ovis aries (Sheep)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi244 – 255PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransportUniRule annotationSAAS annotation
LigandCalciumPROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Solute carrier family 25 member 12Imported
Gene namesi
Name:SLC25A12Imported
OrganismiOvis aries (Sheep)Imported
Taxonomic identifieri9940 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
Proteomesi
  • UP000002356 Componenti: Chromosome 2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

ExpressionAtlasiW5NU53 baseline

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini160 – 195EF-handInterPro annotationAdd BLAST36
Domaini231 – 266EF-handInterPro annotationAdd BLAST36
Repeati398 – 490SolcarPROSITE-ProRule annotationAdd BLAST93
Repeati498 – 582SolcarPROSITE-ProRule annotationAdd BLAST85
Repeati590 – 678SolcarPROSITE-ProRule annotationAdd BLAST89

Sequence similaritiesi

Belongs to the mitochondrial carrier (TC 2.A.29) family. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

RepeatSAAS annotation, Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00530000062944
OrthoDBiEOG091G08GT

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR002067 Mit_carrier
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00926 MITOCARRIER
SMARTiView protein in SMART
SM00054 EFh, 3 hits
SUPFAMiSSF103506 SSF103506, 1 hit
SSF47473 SSF47473, 2 hits
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 2 hits
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

W5NU53-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLASVTWPQT LAPRPXXXXX XXXXXXXXXX XXXXXXXGTR ASRGSRGRSS
60 70 80 90 100
PLQPREAGCS SGSRTLSEPP RPGGMEEACQ TTKRGDPQEL RNIFLQYAST
110 120 130 140 150
EVDGEHYMTP EDFVQRYLGL YNDPNSNPKI VQLLAGVADQ TKDGLISYQE
160 170 180 190 200
FLAFESVLCA PDSMFIVAFQ LFDKSGNGEV TFENVKEIFG QTTIHHHIPF
210 220 230 240 250
NWDCEFIRLH FGHNRKKHLN YTEFTQFLQE LQLEHARQAF ALKDKSKSGL
260 270 280 290 300
ISGLDFSDIM VTIRSHMLTP FVEENLVSAA GGSISHQVSF SYFNAFNSLL
310 320 330 340 350
NNMELVRKIY STLAGTRKDV EVTKEEFAQS AIRYGQVTPL EIDILYQLSD
360 370 380 390 400
LYNATGRLTL ADIERIAPLA EGALPYNLAE LQRQQSHGLG RPIWLQIAES
410 420 430 440 450
AYRFTLGSVA GAVGATAVYP IDLVKTRMQN QRGTGSVVGE LMYKNSFDCF
460 470 480 490 500
KKVLRYEGFF GLYRGLIPQL IGVAPEKAIK LTVNDFVRDK FTRRDGSIPL
510 520 530 540 550
LAEILAGGCA GGSQVIFTNP LEIVKIRLQV AGEITTGPRV SALNVLRDLG
560 570 580 590 600
LFGLYKGAKA CFLRDIPFSA IYFPVYAHCK LLLADENGHV GGINLLAAGA
610 620 630 640 650
MAGVPAASLV TPADVIKTRL QVAARAGQTT YSGVIDCFRK ILREEGPSAF
660 670 680 690 700
WKGTAARVFR SSPQFGVTLV TYELLQRWFY IDFGGLKPSG SEPTPKSRIA
710 720 730 740 750
DLPPANPDHI GGYRLATATF AGIENKFGLY LPKFKPPSVA VVQPKVAAAA

Q
Length:751
Mass (Da):82,626
Last modified:April 16, 2014 - v1
Checksum:i85B97421CDD21042
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AMGL01052689 Genomic DNA No translation available.
AMGL01052690 Genomic DNA No translation available.
AMGL01052691 Genomic DNA No translation available.
AMGL01052692 Genomic DNA No translation available.
AMGL01052693 Genomic DNA No translation available.
AMGL01052694 Genomic DNA No translation available.
AMGL01052695 Genomic DNA No translation available.
AMGL01052696 Genomic DNA No translation available.
AMGL01052697 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSOART00000001740; ENSOARP00000001697; ENSOARG00000001611

Similar proteinsi

Entry informationi

Entry nameiW5NU53_SHEEP
AccessioniPrimary (citable) accession number: W5NU53
Entry historyiIntegrated into UniProtKB/TrEMBL: April 16, 2014
Last sequence update: April 16, 2014
Last modified: June 20, 2018
This is version 32 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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