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Protein
Submitted name:

Trio Rho guanine nucleotide exchange factor b

Gene
N/A
Organism
Lepisosteus oculatus (Spotted gar)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseSAAS annotation, Transferase

Names & Taxonomyi

Protein namesi
Submitted name:
Trio Rho guanine nucleotide exchange factor bImported
OrganismiLepisosteus oculatus (Spotted gar)Imported
Taxonomic identifieri7918 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiHolosteiSemionotiformesLepisosteidaeLepisosteus
Proteomesi
  • UP000018468 Componenti: Linkage group LG11

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini53 – 199CRAL-TRIOInterPro annotationAdd BLAST147
Domaini1281 – 1456DHInterPro annotationAdd BLAST176
Domaini1468 – 1580PHInterPro annotationAdd BLAST113
Domaini1644 – 1709SH3InterPro annotationAdd BLAST66
Domaini1957 – 2133DHInterPro annotationAdd BLAST177
Domaini2145 – 2260PHInterPro annotationAdd BLAST116
Domaini2513 – 2578SH3InterPro annotationAdd BLAST66
Domaini2643 – 2733Ig-likeInterPro annotationAdd BLAST91
Domaini2754 – 3008Protein kinaseInterPro annotationAdd BLAST255

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili743 – 773Sequence analysisAdd BLAST31
Coiled coili874 – 894Sequence analysisAdd BLAST21
Coiled coili932 – 952Sequence analysisAdd BLAST21
Coiled coili1164 – 1184Sequence analysisAdd BLAST21
Coiled coili1894 – 1914Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, RepeatSAAS annotation, SH3 domainPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00920000148975

Family and domain databases

CDDicd00160 RhoGEF, 2 hits
cd00170 SEC14, 1 hit
Gene3Di1.20.900.10, 2 hits
2.30.29.30, 2 hits
2.60.40.10, 1 hit
3.40.525.10, 1 hit
InterProiView protein in InterPro
IPR001251 CRAL-TRIO_dom
IPR036865 CRAL-TRIO_dom_sf
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR011009 Kinase-like_dom_sf
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR018159 Spectrin/alpha-actinin
IPR002017 Spectrin_repeat
IPR028570 TRIO
PANTHERiPTHR22826:SF104 PTHR22826:SF104, 6 hits
PfamiView protein in Pfam
PF00650 CRAL_TRIO, 1 hit
PF07679 I-set, 1 hit
PF00169 PH, 1 hit
PF00069 Pkinase, 1 hit
PF00621 RhoGEF, 2 hits
PF00018 SH3_1, 1 hit
PF00435 Spectrin, 4 hits
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00408 IGc2, 1 hit
SM00233 PH, 2 hits
SM00325 RhoGEF, 2 hits
SM00220 S_TKc, 1 hit
SM00516 SEC14, 1 hit
SM00326 SH3, 2 hits
SM00150 SPEC, 7 hits
SUPFAMiSSF48065 SSF48065, 2 hits
SSF48726 SSF48726, 1 hit
SSF50044 SSF50044, 2 hits
SSF52087 SSF52087, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50191 CRAL_TRIO, 1 hit
PS50010 DH_2, 2 hits
PS50835 IG_LIKE, 1 hit
PS50003 PH_DOMAIN, 2 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
PS50002 SH3, 2 hits

Sequencei

Sequence statusi: Complete.

W5LXL5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAGEGAEET AKDAADIAAF YKSDLSLPKC EPKLDVPSQI AGFRKNDEMK
60 70 80 90 100
AMEVLPILKE KVAFLSGGRD KRGGPVLTFP ARSNHDRIRQ EDLRRLISYL
110 120 130 140 150
AGIPSEEVCK QGFTVIVDMR GSKWDSIKPL LKILQESFPC CIHVALIIKP
160 170 180 190 200
DNFWQKQRTN FGSSKFEFET SMVSLEGLTK VVDPSQLTPD FEGSLDYNHE
210 220 230 240 250
EWIEIRVAFE DFISNATHML SRLEELQEIL AKKDFPQDLE GARRMIEEHS
260 270 280 290 300
QLKKKVVKAP IEDLDTEGHK LLQRIQGSDG FPNKNAVTAN ADMQSLVPKV
310 320 330 340 350
STMLDKLHST RQHLQQMWHV RKLKLDQCFQ LRLFEQDAEK MFDWIMHNKG
360 370 380 390 400
LFLTSYTEIG TSHPHAMELQ TQHSHFAMNC MNVYVNINRI VSVGSRLLES
410 420 430 440 450
GHYASQQIKQ ISSQLEQEWK AFAAALDERS TLLDMSAVFH QKTEQYMNNV
460 470 480 490 500
DSWCKACGEL DLPSELQDLE DAIHHHQGLY DHITAAYSEV SQDGKALLDK
510 520 530 540 550
LQRPLTPGSA DSLTASANYS KAVHHVLDII HEVLHHQRQL ENIWQHRKVR
560 570 580 590 600
LHQRLQLCVF QQDVQQVLDW IENHGEAFLS KHTGVGKSLH RARALQKRHE
610 620 630 640 650
DFEEVAQNTY TNADKLLEAA EQLAQTGECD PEEIYQAAHQ LEDRIQDFVR
660 670 680 690 700
RVEQRKVLLD MSVSFHTHVK ELWTWLEELQ KELLDDVYAE SVEAVQDLIK
710 720 730 740 750
RFGQQKQTTL QVTVNVIKEG EDLIQQLRDS AISSNKTPHN SSINHIESVL
760 770 780 790 800
QQLDEAQAQM EELFQERKIK LELFLQLRVF ERDAIDIISD LESWNDELSQ
810 820 830 840 850
QMNDFDTEDL TLAEQRLQHH ADKALTMNNL TFDVIHQGQE LLQYVNEVQT
860 870 880 890 900
SGVELLCDRD VDMATRVQDL LEFLHEKQQE LDLAAEQHRR HLEQCVQLRH
910 920 930 940 950
LQAEVKQVLG WIRNGESMLN AGLITASSLQ EAEQLQREHE QFQHAIEKTH
960 970 980 990 1000
QSALQVQQKA EAMLQANHYD MDMIRDCAEK VASHWQQLML KMEDRLKLVN
1010 1020 1030 1040 1050
ASVAFYKTSE QVCSVLESLE QEYKREEDWC GGADKLGPNC ESDHVTPMIS
1060 1070 1080 1090 1100
KHLEQKEAFL KACTLARRNA DVFLKYLHRN SVNMPGTLTH VKAPEQQVKN
1110 1120 1130 1140 1150
ILNELLQREN RVLHFWTMRK RRLDQCQQYV VFERSAKQAL EWIHDTGEFY
1160 1170 1180 1190 1200
LSTHTSTGSS IHHTQELLKE HEEFQITAKQ TKERVKLLIQ LADGFCDKGH
1210 1220 1230 1240 1250
AHAVEIKKWV TAVDKRYRDF SLRMDKYRTS LEKALGISSD SNKSSKDLQL
1260 1270 1280 1290 1300
DIIPASAPGS EVKLRDAAHE LNEERRKSAR RKEFIMAELI QTEKAYVRDL
1310 1320 1330 1340 1350
RECMDTYLWE MTSGVEEIPP GIVNKEHIIF GNMQDLYEFH HNIFLKELEK
1360 1370 1380 1390 1400
YEQLPEDVGH CFVTWADKFQ MYVTYCKNKP DSTQLILDNA GPYFDEIQQR
1410 1420 1430 1440 1450
HRLANSISSY LIKPVQRITK YQLLLKELLT CCEEGKGEIK DGLEVMLSVP
1460 1470 1480 1490 1500
KRANDAMHLS MLEGFDENIE SQGELILQES FQVWDPKTLI RKGRERHLFL
1510 1520 1530 1540 1550
FEMSLVFSKE VKDSNGRSKY IYKSKLFTSE LGVTEHVEGD PCKFALWLGR
1560 1570 1580 1590 1600
TPTSDNKIVL KASSIENKQD WIKHIREVIQ ERTIHLKGAL KEPIHIPKAT
1610 1620 1630 1640 1650
TTKQKGRREG EDLDSQGDGS SQPDTISIAS RTSQNTLDSD KLSGGCELTV
1660 1670 1680 1690 1700
VIHDFVASNG NELTVRRGQT VEVLERPHDK PDWCLVRTTD RSPAAEGLVP
1710 1720 1730 1740 1750
CSTLCIAHSR SSMEMEGIFN HKDSLSVSSN DASPPASGGS LQPHGIVSQS
1760 1770 1780 1790 1800
SPGPKRPGNT LRKWLTSPVR RLSSGKADGH VKKLAHKHKK SRDVRKSADA
1810 1820 1830 1840 1850
GSQKDSDDSA ATPQDETVEE RVRNEGLSSG TLSKSSSSGM QSCGEEEGEE
1860 1870 1880 1890 1900
GADSVPLPPP MAIQQHSLLQ PDSQDDKTSS RLSVRPTSSE TPSAAELVSA
1910 1920 1930 1940 1950
IEELVKSKMA LEDRPSSLSV EQGDSSSPSF NPSDNSLLSS SSPIDEMEER
1960 1970 1980 1990 2000
KCSFFKRRHY VLQELVETER DYVRDLGYVV EGYMNKMKED GVPDDMKGKD
2010 2020 2030 2040 2050
KIVFGNIHQI YDWHKDFFLG ELEKCLEDPD KLASLFVKHE RRLHMYIVYC
2060 2070 2080 2090 2100
QNKPKSEHIV SEYLDTYFED LKQRLGHRLQ ITDLLIKPVQ RIMKYQLLLK
2110 2120 2130 2140 2150
DFLKYSKKAG VDTTELEKAV EVMCIVPKRC NDMMNVGRLQ GFDGKIVAQG
2160 2170 2180 2190 2200
RLLLQDTFLV SDPDTGLLAR MKERRVFLFE QIIIFSEPLD RKKGFSMPGY
2210 2220 2230 2240 2250
LFKNSIKMSC LGLEDNVDGD PCKFALASRS ANSTPETYIL HSANPGVRQV
2260 2270 2280 2290 2300
WIHEINQILE NQRNFLNALT SPIEYQRNHV GAAAPSSTSG GACSSAGAAP
2310 2320 2330 2340 2350
APSGGAAGGR PRPSRIPQPV RLHSPVLVSS GASAPAEGPD KMSGTSARAP
2360 2370 2380 2390 2400
SLLPAGAGGS PSPAGAGDKD GENDALKMKL LESARGSKHP SSVEDSQTHT
2410 2420 2430 2440 2450
PRATVGPLTL GKPRPGTVSP LGSPLPPPSF GKEAFTPGSP VQKGPSFWSS
2460 2470 2480 2490 2500
IPASPASRPG SFTFPSDTDS LGRQAHRHST HSKDADRMST CSSASEQSVH
2510 2520 2530 2540 2550
STQSNGSESS SSSNISTMLV TQDYMAVKED EINVYQGEVV QILASNQQNM
2560 2570 2580 2590 2600
FLVFRAANEQ SPAAEGWIPG YVLGHTSAVI PDIPEGTIKK SSSWHTALRI
2610 2620 2630 2640 2650
RKKSEKKDKE GKLENGYRKS REGLANKVSV KLLNPNYIYD VPPEFLLPLS
2660 2670 2680 2690 2700
DVTCENGESV TLRCKVCGRP KATVTWKGPD QNTLSSNGHV SIAYSDSGEA
2710 2720 2730 2740 2750
TLRIVGVSAE DDGTYTCVAT NDVGSVSSSA SLRVLGPSHD GIRVVWKDNF
2760 2770 2780 2790 2800
ESFYAEVAEL GRGRFSVVKK CDQRGTKRAV AAKFVSKKLM KRDQVTHELS
2810 2820 2830 2840 2850
ILQHLQHPHL AALLDTFETS ASFVLVLEMA DQGRLLDYIV SWGNLTEEKV
2860 2870 2880 2890 2900
TAYLREILEA LHYLHNCRIA HLDLKPENVL VDQTSAQPTV KLADFGDAVQ
2910 2920 2930 2940 2950
LNSTYYIHPL LGSPEFAAPE LILGNPVSLS SDTWSVGVLT YVILSGASPF
2960 2970 2980 2990 3000
LDESVEETCL NICRLDFSFP DDYFQGVSQA AKDFMCFLLQ GDPAKRPPAG
3010 3020 3030 3040 3050
VCLQESWLQP GGRHNAECID TSRLISFIDR RKHQNDVRPI GSIRNFLQSR

LMPRV
Length:3,055
Mass (Da):343,815
Last modified:April 16, 2014 - v1
Checksum:iDD9C75B1C2D2144F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AHAT01012339 Genomic DNA No translation available.
RefSeqiXP_015212411.1, XM_015356925.1

Genome annotation databases

EnsembliENSLOCT00000000876; ENSLOCP00000000872; ENSLOCG00000000744
GeneIDi102697311

Similar proteinsi

Entry informationi

Entry nameiW5LXL5_LEPOC
AccessioniPrimary (citable) accession number: W5LXL5
Entry historyiIntegrated into UniProtKB/TrEMBL: April 16, 2014
Last sequence update: April 16, 2014
Last modified: July 18, 2018
This is version 39 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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