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Protein

Mediator of RNA polymerase II transcription subunit 6

Gene
N/A
Organism
Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.UniRule annotation

GO - Biological processi

Keywordsi

Molecular functionActivatorUniRule annotation
Biological processTranscription, Transcription regulationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Mediator of RNA polymerase II transcription subunit 6UniRule annotation
Alternative name(s):
Mediator complex subunit 6UniRule annotation
OrganismiAstyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus)Imported
Taxonomic identifieri7994 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCharaciformesCharacoideiCharacidaeCharacidae incertae sedisAstyanax cladeAstyanax
Proteomesi
  • UP000018467 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

Interactioni

Subunit structurei

Component of the Mediator complex.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the Mediator complex subunit 6 family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00390000017666
KOiK15128
OMAiYARYHPN
OrthoDBiEOG091G0MJA

Family and domain databases

Gene3Di3.10.450.580, 1 hit
InterProiView protein in InterPro
IPR038566 Med6_sf
IPR007018 Mediator_Med6
IPR016820 Mediator_Med6_met/pln
PANTHERiPTHR13104 PTHR13104, 1 hit
PfamiView protein in Pfam
PF04934 Med6, 1 hit
PIRSFiPIRSF023869 Mediator_MED6_meta/pln, 1 hit

Sequencei

Sequence statusi: Complete.

W5LQ34-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAGDLRDNL LGISWVDSGW VPILNPGNVL DYFSERSNPF YDRTCNNEMV
60 70 80 90 100
KMQRLTLDHL NQMVGVEYIL LHAQEPILYI VRKQQRQSPT QVIPLADYYI
110 120 130 140 150
IAGVVYQAPD LGSVISSRVL SAVHGIQSAF DEAMSFCRYH PSKGYWWHFK
160 170 180 190 200
DQEEREKVKP KSKKKEEPSS LFQRQRVDAL LLDLRNKFPP MFYQPKPGEK
210 220 230 240
PIPVEVKKEP ELLAEPTKQE ERETATKTPA PSGPSKPPPE KRARLQ
Length:246
Mass (Da):28,259
Last modified:April 16, 2014 - v1
Checksum:i5A0F97ACE31B9587
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
APWO01083915 Genomic DNA No translation available.
APWO01083916 Genomic DNA No translation available.
RefSeqiXP_007247631.1, XM_007247569.2

Genome annotation databases

EnsembliENSAMXT00000022110; ENSAMXP00000022110; ENSAMXG00000021470
GeneIDi103030122
KEGGiamex:103030122

Similar proteinsi

Entry informationi

Entry nameiW5LQ34_ASTMX
AccessioniPrimary (citable) accession number: W5LQ34
Entry historyiIntegrated into UniProtKB/TrEMBL: April 16, 2014
Last sequence update: April 16, 2014
Last modified: July 18, 2018
This is version 17 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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