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Entry version 45 (12 Aug 2020)
Sequence version 2 (05 Dec 2018)
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Protein
Submitted name:

Afadin, adherens junction formation factor a

Gene
N/A
Organism
Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesionARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Afadin, adherens junction formation factor aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAstyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7994 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCharaciformesCharacoideiCharacidaeAstyanax
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000018467 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7994.ENSAMXP00000018401

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini38 – 133Ras-associatingInterPro annotationAdd BLAST96
Domaini243 – 339Ras-associatingInterPro annotationAdd BLAST97
Domaini640 – 880DiluteInterPro annotationAdd BLAST241
Domaini977 – 1063PDZInterPro annotationAdd BLAST87

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni492 – 546DisorderedSequence analysisAdd BLAST55
Regioni1074 – 1554DisorderedSequence analysisAdd BLAST481
Regioni1596 – 1904DisorderedSequence analysisAdd BLAST309

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili152 – 172Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi522 – 536PolarSequence analysisAdd BLAST15
Compositional biasi1084 – 1098PolyampholyteSequence analysisAdd BLAST15
Compositional biasi1102 – 1117PolarSequence analysisAdd BLAST16
Compositional biasi1123 – 1138PolyampholyteSequence analysisAdd BLAST16
Compositional biasi1140 – 1154PolarSequence analysisAdd BLAST15
Compositional biasi1261 – 1290PolyampholyteSequence analysisAdd BLAST30
Compositional biasi1291 – 1328PolarSequence analysisAdd BLAST38
Compositional biasi1348 – 1380Pro-richSequence analysisAdd BLAST33
Compositional biasi1388 – 1424PolyampholyteSequence analysisAdd BLAST37
Compositional biasi1448 – 1501Pro-richSequence analysisAdd BLAST54
Compositional biasi1504 – 1519PolarSequence analysisAdd BLAST16
Compositional biasi1617 – 1706PolyampholyteSequence analysisAdd BLAST90
Compositional biasi1709 – 1723Pro-richSequence analysisAdd BLAST15
Compositional biasi1747 – 1764PolarSequence analysisAdd BLAST18
Compositional biasi1797 – 1811Pro-richSequence analysisAdd BLAST15
Compositional biasi1854 – 1873PolarSequence analysisAdd BLAST20

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1892, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155237

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000594_1_0_1

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00060, FHA, 1 hit
cd15471, Myo5p-like_CBD_afadin, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.42.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR037977, CBD_Afadin
IPR002710, Dilute_dom
IPR000253, FHA_dom
IPR001478, PDZ
IPR036034, PDZ_sf
IPR000159, RA_dom
IPR008984, SMAD_FHA_dom_sf
IPR029071, Ubiquitin-like_domsf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01843, DIL, 1 hit
PF00498, FHA, 1 hit
PF00595, PDZ, 1 hit
PF00788, RA, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01132, DIL, 1 hit
SM00228, PDZ, 1 hit
SM00314, RA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49879, SSF49879, 1 hit
SSF50156, SSF50156, 1 hit
SSF54236, SSF54236, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51126, DILUTE, 1 hit
PS50106, PDZ, 1 hit
PS50200, RA, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

W5LEY9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGSREEERR KLADIINHWN ANRLDLFEIS QPTEELEFHG VMRFYFQDRV
60 70 80 90 100
AGNFATKCIR VSSTATTQDV IETLAEKFRP DMRMLSSPKY SLYEVHVSGE
110 120 130 140 150
ERKLDLDEKP LVVQLNWNKD DREGRFVLKN ENDIIPKKAQ SNGPEKEKEG
160 170 180 190 200
VIQNFKRTLS KKEKKKEKKK DKEAFARIPD GDDHALNRED GDSRLAAEVY
210 220 230 240 250
KDMPETSFTR TISNPEVVMK RRRQQKLEKR MQEFRSGDGR PDSGGTLRIY
260 270 280 290 300
ADSLKPNIPY KTILLSTTDT ADFAVAEALE KYGLEKENPR EYCIARVVHS
310 320 330 340 350
DDKPVKETIL DDTECPLQIF RDWTSDKEAL VFQLKKRPPD YIAKKGRKSD
360 370 380 390 400
ERMGPLHGSL PPEKLPYLVE LSPGRGNHYA YYGYRQHEDG SDSRDKPKLY
410 420 430 440 450
RLQHSLTEVG SDRSEDGNIQ LFGPGILPHH CNLMHADGLV MVTPVSMDAE
460 470 480 490 500
TFVDGQRIQD TTVLRSGMTL QFGAAHVFKF VDPSYDHVMA KRDPGPMVKG
510 520 530 540 550
RNKSGSVPET TFDLHGDVHS GTALPTSKSS GKLDMDRSGN GSERGMVKPM
560 570 580 590 600
IRGEQQDFSK HDGRPHDGPE LTLPASIEFR ENSEDAFLSA IINYTNSSTV
610 620 630 640 650
HFKLSPTYVL YMTCRYVMSS QYRPDISPSE RTHKVIAIVN KMVSMMEGVI
660 670 680 690 700
QKQKNIAGAL AFWMANASEL LNFIKQDKDL SRITLDAQDV LAHLVQMAFK
710 720 730 740 750
YLVHCLQSDL NNYMPAFLDD PEEQNPQRPK IEDVLHTLTG AMSLLRRCRV
760 770 780 790 800
NAALTIQLFS QLFHFINMWL FNKLVTESDS GLCSHYWGAI LRQQLSHIEA
810 820 830 840 850
WAEKQGLELA ADCHLSRIVQ ATTLLTMDKY SVQDVQNINN TCFKLNSLQL
860 870 880 890 900
NALMSNYHCA PDEPYIPHEL IDHVVAVAEN TADELARSDG REVQLEEDPD
910 920 930 940 950
LQLPFLLPED GYSCDVVRNI PNGFQEFLEP LCQRGFCRLT PHPRSPGTWT
960 970 980 990 1000
VYFEGADCDS HFSTDNSELP MRKEPEVVTV TLKKHNGMGL SIVAAKGAGQ
1010 1020 1030 1040 1050
EKLGIYIKSV VKGGAADMDG RLAAGDQLLS VDGRSLVGLS QERAAELMTR
1060 1070 1080 1090 1100
TGSVVTLEVA KQGAIYHGLA TLLNQPSPMM PRASDRGRGD KGKARPKSEG
1110 1120 1130 1140 1150
FELYNNSVQN GSPESPQGAW DTYPEPKRED RLLKNRADHR SSPNVANQAQ
1160 1170 1180 1190 1200
SPGGKSAYPG APGKITSVST GNLCPDEEPS PPRPEAYPIP TQTYPREYFT
1210 1220 1230 1240 1250
FPASKPQDRM GPGSGQPWQS NEPEPLPPMD DHHHNSMAMQ RVARSQEELC
1260 1270 1280 1290 1300
DPPVGYPADR LPERLRQEDL RLLQQQREAE YQRDRVAGEH WNHQVSSSVE
1310 1320 1330 1340 1350
SSTSSQEHLN YSSSSSGTKP QSNHKSGAGR WKTPIGPHSG PVGVSQPSRT
1360 1370 1380 1390 1400
DLPPPPPPPP PALYDYEPQT ELPLPPPPAI SQQQQQAMAD RKKREEQQRW
1410 1420 1430 1440 1450
YEKEKARLEE ERERKRREQE RKLGQIRNPM GPPPALHNNQ HGPTLPPAPQ
1460 1470 1480 1490 1500
HQQMPPPQPP VSMQLPQPYL PQPQQPPQTQ PPRPEKLSTL PRAPPPPSQP
1510 1520 1530 1540 1550
LDTVIRDLQP QQQPRTIERR DLQYITISKE ELSASDSLSP DPWKRDAREK
1560 1570 1580 1590 1600
LEKQQQMHIV DLLDKEIQEL QAKPERTAEE SDRLRKLMLE WQFQKRLQES
1610 1620 1630 1640 1650
KQSEEDEEEE DDEDVDTMLI MQRLEAEKRA RLQDEERRRK QQLEEIRKRE
1660 1670 1680 1690 1700
AEERAKQEEE RRWREEERAR RETDEKRRQE EEYYTRLEAE RRRQHDEAER
1710 1720 1730 1740 1750
KLLTPDEPGL YRPPLPRDYQ PPLPAPATNN NSISNNSNPP PTPPQRNTSY
1760 1770 1780 1790 1800
LKTQVVSPDT LYTAKFVSYN DEEEEDAGVA GQVKLSATRK SYGDLPAAPK
1810 1820 1830 1840 1850
PQPPPPTARK PRPLSDGIFL SGSFQLPPAA NANSTAPKAG QAPPPPAKPS
1860 1870 1880 1890 1900
FISSTAPKGF NSYTGNTTTG VVGSGEVYKD PREKSTGKGG QEQENSIGGA
1910 1920 1930
PENLTFKERQ RLFSQGKEVS NKVKASRKLM ELENELNTK
Length:1,939
Mass (Da):219,285
Last modified:December 5, 2018 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2C6B846C7E9812A6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3B1IQ43A0A3B1IQ43_ASTMX
Afadin, adherens junction formation...
1,924Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B1JVV9A0A3B1JVV9_ASTMX
Afadin, adherens junction formation...
1,917Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B1KGN6A0A3B1KGN6_ASTMX
Afadin, adherens junction formation...
1,596Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSAMXT00000018401; ENSAMXP00000018401; ENSAMXG00000017862
ENSAMXT00000051828; ENSAMXP00000039634; ENSAMXG00000017862

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7994.ENSAMXP00000018401

Genome annotation databases

EnsembliENSAMXT00000018401; ENSAMXP00000018401; ENSAMXG00000017862
ENSAMXT00000051828; ENSAMXP00000039634; ENSAMXG00000017862

Phylogenomic databases

eggNOGiKOG1892, Eukaryota
GeneTreeiENSGT00940000155237
HOGENOMiCLU_000594_1_0_1

Family and domain databases

CDDicd00060, FHA, 1 hit
cd15471, Myo5p-like_CBD_afadin, 1 hit
Gene3Di2.30.42.10, 1 hit
InterProiView protein in InterPro
IPR037977, CBD_Afadin
IPR002710, Dilute_dom
IPR000253, FHA_dom
IPR001478, PDZ
IPR036034, PDZ_sf
IPR000159, RA_dom
IPR008984, SMAD_FHA_dom_sf
IPR029071, Ubiquitin-like_domsf
PfamiView protein in Pfam
PF01843, DIL, 1 hit
PF00498, FHA, 1 hit
PF00595, PDZ, 1 hit
PF00788, RA, 2 hits
SMARTiView protein in SMART
SM01132, DIL, 1 hit
SM00228, PDZ, 1 hit
SM00314, RA, 2 hits
SUPFAMiSSF49879, SSF49879, 1 hit
SSF50156, SSF50156, 1 hit
SSF54236, SSF54236, 2 hits
PROSITEiView protein in PROSITE
PS51126, DILUTE, 1 hit
PS50106, PDZ, 1 hit
PS50200, RA, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiW5LEY9_ASTMX
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: W5LEY9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 16, 2014
Last sequence update: December 5, 2018
Last modified: August 12, 2020
This is version 45 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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