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Entry version 34 (16 Jan 2019)
Sequence version 1 (19 Mar 2014)
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Protein
Submitted name:

Uncharacterized protein

Gene
N/A
Organism
Strongylocentrotus purpuratus (Purple sea urchin)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi762 – 769ATPPROSITE-ProRule annotation8
Nucleotide bindingi1382 – 1389ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATPase activity, coupled to transmembrane movement of substances Source: GO_Central
  • ATP binding Source: UniProtKB-UniRule

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandATP-bindingPROSITE-ProRule annotation, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiStrongylocentrotus purpuratus (Purple sea urchin)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7668 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEchinodermataEleutherozoaEchinozoaEchinoideaEuechinoideaEchinaceaEchinoidaStrongylocentrotidaeStrongylocentrotus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007110 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei39 – 62HelicalSequence analysisAdd BLAST24
Transmembranei83 – 102HelicalSequence analysisAdd BLAST20
Transmembranei114 – 134HelicalSequence analysisAdd BLAST21
Transmembranei146 – 164HelicalSequence analysisAdd BLAST19
Transmembranei184 – 202HelicalSequence analysisAdd BLAST19
Transmembranei315 – 336HelicalSequence analysisAdd BLAST22
Transmembranei356 – 373HelicalSequence analysisAdd BLAST18
Transmembranei436 – 459HelicalSequence analysisAdd BLAST24
Transmembranei465 – 485HelicalSequence analysisAdd BLAST21
Transmembranei541 – 570HelicalSequence analysisAdd BLAST30
Transmembranei590 – 609HelicalSequence analysisAdd BLAST20
Transmembranei1032 – 1052HelicalSequence analysisAdd BLAST21
Transmembranei1072 – 1101HelicalSequence analysisAdd BLAST30
Transmembranei1143 – 1163HelicalSequence analysisAdd BLAST21
Transmembranei1169 – 1191HelicalSequence analysisAdd BLAST23
Transmembranei1261 – 1281HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7668.SPU_025903tr

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini308 – 606ABC transmembrane type-1InterPro annotationAdd BLAST299
Domaini727 – 955ABC transporterInterPro annotationAdd BLAST229
Domaini1074 – 1314ABC transmembrane type-1InterPro annotationAdd BLAST241
Domaini1348 – 1582ABC transporterInterPro annotationAdd BLAST235

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili272 – 292Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0054 Eukaryota
COG1132 LUCA

Identification of Orthologs from Complete Genome Data

More...
OMAi
YAAQKSW

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1560.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR027417 P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382 AAA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

W4ZCL6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGSDDWEWFC GTNSSDLPDF DNQSWNYEDV LSNECLVDAF IAGTQIGFFV
60 70 80 90 100
LALLVLFLTA CCTSRSDVPH RFLLRYVTHS PRYLGTFVLV VMSVASVAEG
110 120 130 140 150
ILTDSTYTNQ PTQPHLYITG ISSALSGVVS LLYFGRLERW RVWKMSLLLL
160 170 180 190 200
VYWVASLATV SIQIESLIHQ GYNDVHVTAF DINIIMIAVY SFFLLLELYF
210 220 230 240 250
LVDNWFGWSP GVDEVPRDLK DERMYYMERY VDIFSQLVHW WMNWLFVLGF
260 270 280 290 300
KRPLEMDDLG SIPEVHSAEY NHRRFKNNFK REIERAKEEE REPSLFKVYF
310 320 330 340 350
ATYWVRMLAG AILKFITDMG AYVGPLAIGG ITLYVTDAVY GEHEDVPPHP
360 370 380 390 400
VSVKEFFADG YVLIGCIFVT ALIRHMCDQT YQFITSIEGI HARSALQSTI
410 420 430 440 450
YEKSLRLSTY AMTGGAMTMG QITNHMSVDA NNIMMFFMFA NEVWATPFKI
460 470 480 490 500
IFSLVLLYLE LGTPALIGAS VFLVVIPFQL AAAVAMGKFI KAVLGTADYR
510 520 530 540 550
LKMSNEMLQG IKLLKLYGWE RIYYEAIKKA RIKELYALLK VYTFFAVTFI
560 570 580 590 600
INAATPIVVT LVSFGTYTPI TGKVLTPDVA FTTLSLFNQM AGPLFMFPFV
610 620 630 640 650
INLFVNWIVS TGRLKTYLLA PEVEGADGVI SDLLKEIDED VDVTDSAESV
660 670 680 690 700
GNSHDDDLSV TIKHPRHRKN RSHSKQRDDA HQLPDKTPLL SGDGSPRGSL
710 720 730 740 750
SYGSTNPIKH GDTSFSGSGD VPDDVAIKIS NGNFTWDPDS NVSILSDINV
760 770 780 790 800
EIPRGKLTVV IGAVGCGKSS LLSAMLNEMT TLSGTVKHNR NTKSIAYAPQ
810 820 830 840 850
KAWLVNATLK DNILFGEEMV NSKYRKVIQA CALQPDIDML PGKDMTEIGE
860 870 880 890 900
KGINLSGGQK QRVSVSRCLY SDRDIIILDD PLSALDMHVG THLFEKGFQG
910 920 930 940 950
ILMKQKKTVI LVTHQLQYLP EADKIIVVKD GRITCQGTPE EVAEADPSIM
960 970 980 990 1000
TESERAIKEV TESEAEGSGA ESESLMNERR ALKRQVSTQM SVLKDGAADK
1010 1020 1030 1040 1050
SAEKAGRLIE EEEKEKGSVS YQMYMYYFRA MGYWLACLMI GCVAMRAGLQ
1060 1070 1080 1090 1100
VVQTSGSQTG PRRDAQPTSY YLRGYAGFSV STVFGSVLSN VFSCIGALLA
1110 1120 1130 1140 1150
ARAIHFALLQ NIIGIPMRFF DTTPVGRILN RLSSDTQWID QRLIHSFNML
1160 1170 1180 1190 1200
LNTLVAVIAS FIVNAIVNSY FIIFLIPIGI IFMCILVYFV ATSRMLQRLE
1210 1220 1230 1240 1250
SVTRSPVFAH FSETLGGLPI IRAYKDEKRF FKNVLGKIDK NNTALVYLYT
1260 1270 1280 1290 1300
ANRWLAIRLD YLGAVVVLIA SLSALLGALY LGVDASLVGL AISYSLEISI
1310 1320 1330 1340 1350
YMNMVVRGCA DLELQMNAME RIRYYTEVEN EEYDGLEPPP EWPQKGEIIL
1360 1370 1380 1390 1400
DNISVRYALE LDPVLHDVSV TIPPGQKLGI CGRTGSGKSS LTLSLFRIID
1410 1420 1430 1440 1450
TFKGRILIDG VDISSVPLIT LRQRLSIIPQ DAVLFTGTIR HNIDPAGVKT
1460 1470 1480 1490 1500
DDELWKALEI AQLKEVVSPL EGGLDYIVTE GGENFSVGQR QLFCLARAFL
1510 1520 1530 1540 1550
RNSTILVMDE ATASIDQETD RILQDVVADV FQDRTVITIA HRVGTILDAD
1560 1570 1580
NILTLSDGRV VEFDSPNTLL EKEDSIFASL VKAGK
Length:1,585
Mass (Da):176,788
Last modified:March 19, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i07E26E45D4DE0DF4
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAGJ04074334 Genomic DNA No translation available.
AAGJ04074335 Genomic DNA No translation available.
AAGJ04074336 Genomic DNA No translation available.

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
SPU_025903-tr; SPU_025903-tr; SPU_025903

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAGJ04074334 Genomic DNA No translation available.
AAGJ04074335 Genomic DNA No translation available.
AAGJ04074336 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protein-protein interaction databases

STRINGi7668.SPU_025903tr

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiSPU_025903-tr; SPU_025903-tr; SPU_025903

Phylogenomic databases

eggNOGiKOG0054 Eukaryota
COG1132 LUCA
OMAiYAAQKSW

Family and domain databases

Gene3Di1.20.1560.10, 2 hits
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiW4ZCL6_STRPU
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: W4ZCL6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 19, 2014
Last sequence update: March 19, 2014
Last modified: January 16, 2019
This is version 34 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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