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UniProtKB - W4ZAI5 (W4ZAI5_STRPU)

Entry version 27 (31 Jul 2019)
Sequence version 1 (19 Mar 2014)
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Protein

ANK_REP_REGION domain-containing protein

Gene
N/A
Organism
Strongylocentrotus purpuratus (Purple sea urchin)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ANK_REP_REGION domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiStrongylocentrotus purpuratus (Purple sea urchin)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7668 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Echinodermata › Eleutherozoa › Echinozoa › Echinoidea › Euechinoidea › Echinacea › Echinoida › Strongylocentrotidae › Strongylocentrotus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007110 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		7668.SPU_025162-tr

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini40 – 295ANK_REP_REGIONInterPro annotationAdd BLAST256
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati40 – 72ANKPROSITE-ProRule annotationAdd BLAST33
Repeati175 – 207ANKPROSITE-ProRule annotationAdd BLAST33
Repeati208 – 240ANKPROSITE-ProRule annotationAdd BLAST33
Repeati241 – 273ANKPROSITE-ProRule annotationAdd BLAST33

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni306 – 396DisorderedSequence analysisAdd BLAST91
Regioni449 – 496DisorderedSequence analysisAdd BLAST48
Regioni608 – 974DisorderedSequence analysisAdd BLAST367
Regioni1007 – 1028DisorderedSequence analysisAdd BLAST22
Regioni1040 – 1115DisorderedSequence analysisAdd BLAST76
Regioni1186 – 1334DisorderedSequence analysisAdd BLAST149

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi331 – 378PolyampholyteSequence analysisAdd BLAST48
Compositional biasi477 – 495PolyampholyteSequence analysisAdd BLAST19
Compositional biasi608 – 622PolyampholyteSequence analysisAdd BLAST15
Compositional biasi637 – 654PolyampholyteSequence analysisAdd BLAST18
Compositional biasi655 – 677AcidicSequence analysisAdd BLAST23
Compositional biasi741 – 756PolarSequence analysisAdd BLAST16
Compositional biasi777 – 794PolarSequence analysisAdd BLAST18
Compositional biasi801 – 846PolarSequence analysisAdd BLAST46
Compositional biasi870 – 884Pro-richSequence analysisAdd BLAST15
Compositional biasi907 – 974PolarSequence analysisAdd BLAST68
Compositional biasi1040 – 1058PolarSequence analysisAdd BLAST19
Compositional biasi1068 – 1115PolarSequence analysisAdd BLAST48
Compositional biasi1186 – 1299PolarSequence analysisAdd BLAST114
Compositional biasi1307 – 1334PolarSequence analysisAdd BLAST28

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

ANK repeatPROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0504 Eukaryota
COG0666 LUCA

Identification of Orthologs from Complete Genome Data

More...OMAi		RYICTIS

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.40.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00023 Ank, 1 hit
PF12796 Ank_2, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00248 ANK, 7 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48403 SSF48403, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

W4ZAI5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASGSISALN ERLRSSAGKG NWEEIEQLLR HGATFEADKY GRTALHYAAH 
        60         70         80         90        100
YGQVKTLRVC ISRGCELDKV DTYGCTALHK AIAPDGHVEA VRALIGEGCD 
       110        120        130        140        150
VDGQDGNGNT CVHEGAMKGF SQSMDVLIKI GKANINTSNK NGNTCVHEGA 
       160        170        180        190        200
MKGFSQSMDV LIKIGKANIH TGNKNGERAI HLACQHGHNQ STRILLKAGS 
       210        220        230        240        250
HPDVKNSSGE TPLHIACLYG QITCARILIS AECDINMKNK DGNTPLHIAA 
       260        270        280        290        300
GLGKLKIARL LLESLCEVKI RNKSNQTPLD VARQTDQRDA ALLIIGAHRM 
       310        320        330        340        350
KKGKLSFFSR NKKKDSSKLD GFGNSSHHHQ SDSSPNDKHK RKHTDDRRGD 
       360        370        380        390        400
DDMDGGQGGA RIRGRREMEA GDRHSSGSSK GKSKKKRDKS QGQNLFVREE 
       410        420        430        440        450
MKKHLKSEKK LQEQIHLGRE LGNCQHTEQG NPHFRTQLFK DKTGKMKKGK 
       460        470        480        490        500
LSFFSRNKKK DSSKLDGFGN SSHHHQSDSS PNDKHKRKHT DDRVPMPVHC 
       510        520        530        540        550
NCTPYIKKLE NQVEASKERL LHEIDISKAR FESRMNNMEK RMTHQAQCMD 
       560        570        580        590        600
QLCKERIAAE KGDCIHRIDK RAREERKAWS EEHDARTDVL RRELRHWFES 
       610        620        630        640        650
RIQPLHEQLS RTMDDAETAS STRRSRPRAG FYRLNGREVV THRKRSKSLG 
       660        670        680        690        700
NVSDCDLEEE DEEDSDEESE DESEDEEEEK EHARKNSRVK ERPVSSSQPS 
       710        720        730        740        750
EQSPHHYKKT ETAKAKDYAK SGAIPKSSRS GSFRLAVSDE DRASGSSSNS 
       760        770        780        790        800
GTPLSMVDGT YRPPLITAHE HSPNTDSHHS LPANFVFPSQ ETDDTESSES 
       810        820        830        840        850
SESETTSQQS LETVSYKPKS ISGVSSSTRD SGLHTLKGSS VSSDRRSHGP 
       860        870        880        890        900
TRADLIAYQA LTVNARPPPP LHAQVRPRHP VSTQPPPAEL RIQASYTPPF 
       910        920        930        940        950
SPPVSPTSTA SQPRSTSTLA SSDGHRVATP STEQPSSDNP SPTDSGKAHS 
       960        970        980        990       1000
TSSGISSGEA SSLQNSSPIK YNIISPYSGQ SYQGTYNPRS SSSSHQPDLF 
      1010       1020       1030       1040       1050
KVIKSETMKT SHDEPPPPYR SKDSASSDNR YRVAQPYHQN VNNANNDQSL 
      1060       1070       1080       1090       1100
NQSRSNEVPP KIGHAPTLSN HYASSLPGGR TISRTDQKRI GSGSDSSTNV 
      1110       1120       1130       1140       1150
KTQSMGYSAA PSRSAASRLG VTPTLGAVRG VSSNNNTTSG KGLNQLHLQP 
      1160       1170       1180       1190       1200
RTQASQQSLP PGYSVVQGRS GSNGAVFAIT RTNQSHAGNL NRPEIPVNKN 
      1210       1220       1230       1240       1250
NNAAPNSTST FVHSGSITSS TSRTFNNHAT SGNQYNVPTG AGTRNNGTFN 
      1260       1270       1280       1290       1300
APNNNFHCSG GTKDSTSGNR ATSSSHSNRT SRESYASNGT LSSDTRNPVR 
      1310       1320       1330       1340       1350
IGGAINGADH SSTNYTIDKR TSGTSNSIPG VNSMSTNRRS GAAFISNGAS 
      1360       1370       1380
NGASLVSTVE SFNRTAAPEQ KLKYTREIIL
Length:1,380
Mass (Da):150,569
Last modified:March 19, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8622A8AA304D0595
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AAGJ04105611 Genomic DNA No translation available.
AAGJ04105612 Genomic DNA No translation available.
AAGJ04105613 Genomic DNA No translation available.

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		SPU_025162-tr; SPU_025162-tr; SPU_025162

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAGJ04105611 Genomic DNA No translation available.
AAGJ04105612 Genomic DNA No translation available.
AAGJ04105613 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi7668.SPU_025162-tr

Genome annotation databases

EnsemblMetazoaiSPU_025162-tr; SPU_025162-tr; SPU_025162

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
COG0666 LUCA
OMAiRYICTIS

Family and domain databases

Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
PfamiView protein in Pfam
PF00023 Ank, 1 hit
PF12796 Ank_2, 2 hits
SMARTiView protein in SMART
SM00248 ANK, 7 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiW4ZAI5_STRPU
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: W4ZAI5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 19, 2014
Last sequence update: March 19, 2014
Last modified: July 31, 2019
This is version 27 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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