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Entry version 29 (31 Jul 2019)
Sequence version 1 (19 Mar 2014)
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Protein

PHD-type domain-containing protein

Gene
N/A
Organism
Strongylocentrotus purpuratus (Purple sea urchin)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
PHD-type domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiStrongylocentrotus purpuratus (Purple sea urchin)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7668 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEchinodermataEleutherozoaEchinozoaEchinoideaEuechinoideaEchinaceaEchinoidaStrongylocentrotidaeStrongylocentrotus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007110 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini74 – 125PHD-typeInterPro annotationAdd BLAST52

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni167 – 416DisorderedSequence analysisAdd BLAST250
Regioni429 – 481DisorderedSequence analysisAdd BLAST53
Regioni928 – 952DisorderedSequence analysisAdd BLAST25
Regioni1081 – 1127DisorderedSequence analysisAdd BLAST47

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili55 – 75Sequence analysisAdd BLAST21
Coiled coili1152 – 1172Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi167 – 189PolarSequence analysisAdd BLAST23
Compositional biasi208 – 234PolarSequence analysisAdd BLAST27
Compositional biasi238 – 295PolyampholyteSequence analysisAdd BLAST58
Compositional biasi296 – 323PolarSequence analysisAdd BLAST28
Compositional biasi341 – 355PolarSequence analysisAdd BLAST15
Compositional biasi373 – 399PolyampholyteSequence analysisAdd BLAST27
Compositional biasi467 – 481PolarSequence analysisAdd BLAST15
Compositional biasi928 – 950PolyampholyteSequence analysisAdd BLAST23
Compositional biasi1103 – 1124PolarSequence analysisAdd BLAST22

Keywords - Domaini

Coiled coilSequence analysis, Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410J488 Eukaryota
ENOG4112AHA LUCA

Identification of Orthologs from Complete Genome Data

More...
OMAi
DNDQSIH

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019786 Zinc_finger_PHD-type_CS
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00628 PHD, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00249 PHD, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57903 SSF57903, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

W4XTE2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKRLVTTEAL FNLLKEWPNI DQLDTTGYRP PLCAWTELAT SLRLKNSIGN
60 70 80 90 100
RKWLYNQWKK NAERLRDRVL EARKLYCVCR TRNDETKPML ACDKCEEWFH
110 120 130 140 150
HKCIGMRNSP SIKKIYFLCP NCTKTSKKPC STNDLSQGAN SAFSFEPQDN
160 170 180 190 200
AKVPAPADRD LIQDDSHANS SIADPSLVDI SQTDCSGQAN SEDDDIHVFK
210 220 230 240 250
GGASVGKPST TKDPSDNDQS IHNGAIPDGD SNNESTSDNS EDDDRSKGKG
260 270 280 290 300
VHVPRTTTEP DNDQSIHDGA KPDDDFNNES TTDNSEDEDR SKGKGVHVPQ
310 320 330 340 350
TTTEPDNDQS IHNGAIPDDD SNNESTSDSS EDDDRSKGKG VHVPQTTTEP
360 370 380 390 400
DNDQSIHDGA ISDDACNNVS TSDNSEDEDR SKGKGVHEPS THTEPDDEAI
410 420 430 440 450
LVETSSYDST SESNTENEDI FVDGTHSEFA MPTFDSNDDI PSDKSNDFQN
460 470 480 490 500
DSSFVGQREE LSDVSDDTMS GNDVTKAPSN LTNPIPKKFQ IHLTSREWEK
510 520 530 540 550
IKPKNFQHKL CGDWTNLIYD KFYKINKSCV LVFTYNRSKL PGSREKKSPI
560 570 580 590 600
LKVEGRCKFK GCCRYHFTLQ KIPKRTKPVT LQVTRLGIIS HRGKEGEKRH
610 620 630 640 650
MKGERRRHVG KELQRKGTTN WYYQKIGQMT EEERKDGNLT ACSTLDVLRK
660 670 680 690 700
ILSENKCSQN LHHDVYQEVN LLQQVYVDVH PSSKFTTGGF IQYFSIYPFK
710 720 730 740 750
VHLLLDEQVQ LYLQQRKKGE VTLHLDATGS VVKKVPGQDH QILYYALIMA
760 770 780 790 800
NTILGRAGIP VLEMLSTDQH ASEIKHFLAR FVNAITTNRQ LAHVIPQRIE
810 820 830 840 850
TDFSWALIQA VLYAFNAEDC KAYLKRSWKI VHRGRKAQEL KGKTYPHLCA
860 870 880 890 900
AHMLHNLSRR LRDITQDKGK KRFILYCFAL LQTTGDVENA SRVFRAMHIT
910 920 930 940 950
FDSQLSTARV KRATEYLQHI INRKGLQEEV DETEDGDPLI QSHDEHPTLS
960 970 980 990 1000
SRESSPWFVH FKNVAESTTA EMQITDDETS CTSNDYYTPG LIDLLIKQFM
1010 1020 1030 1040 1050
HIYPLWSAVL LGDLQRYASD HPSLNNTINP NRVTNAIVEN WFGNVKKDFC
1060 1070 1080 1090 1100
GGNRTRLRPG EFIRKAYTNV IGRVREVELR PTKQMRKKKK RRLVREGQDS
1110 1120 1130 1140 1150
MRSTPDVKTS NPATNKQKKE SSLPRWGGNA TYKGKTIKLS NTCTIDNFLV
1160 1170 1180 1190 1200
ILTRLVQQYQ KLRENLQQGS KTCREIVKVL DLCSDGQWNE GKVQWLFKIC
1210 1220 1230 1240 1250
RIEVQVHDTQ HVNAFGSEYD FFVRHMEHIQ GNNQMSTCSN RECGRRIRNT
1260 1270 1280 1290 1300
YNGLIQLGLP LDRNIGSLQD ALDVWIEAFT SPCKSHSLPE RNDCKGTRRW
1310 1320 1330 1340
DQRQFTHFKV PPLLFLNPKV YSEDKKREVT LLHQHVITVN KLR
Length:1,343
Mass (Da):153,113
Last modified:March 19, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5AC3FD2CC1445E86
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAGJ04047344 Genomic DNA No translation available.

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
SPU_006692-tr; SPU_006692-tr; SPU_006692

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAGJ04047344 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsemblMetazoaiSPU_006692-tr; SPU_006692-tr; SPU_006692

Phylogenomic databases

eggNOGiENOG410J488 Eukaryota
ENOG4112AHA LUCA
OMAiDNDQSIH

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR019786 Zinc_finger_PHD-type_CS
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF00628 PHD, 1 hit
SMARTiView protein in SMART
SM00249 PHD, 1 hit
SUPFAMiSSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiW4XTE2_STRPU
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: W4XTE2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 19, 2014
Last sequence update: March 19, 2014
Last modified: July 31, 2019
This is version 29 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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