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Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
[Clostridium] straminisolvens JCM 21531
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.UniRule annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotation
Biological processAntibiotic resistanceUniRule annotationSAAS annotation, Cell shape, Cell wall biogenesis/degradationUniRule annotationSAAS annotation, Peptidoglycan synthesisUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
Alternative name(s):
Bacitracin resistance proteinUniRule annotation
Undecaprenyl pyrophosphate phosphataseUniRule annotation
Gene namesi
Name:uppPUniRule annotation
ORF Names:JCM21531_980Imported
Organismi[Clostridium] straminisolvens JCM 21531Imported
Taxonomic identifieri1294263 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesRuminococcaceaeRuminiclostridium
Proteomesi
  • UP000019109 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei49 – 67HelicalUniRule annotationAdd BLAST19
Transmembranei88 – 106HelicalUniRule annotationAdd BLAST19
Transmembranei112 – 134HelicalUniRule annotationAdd BLAST23
Transmembranei155 – 182HelicalUniRule annotationAdd BLAST28
Transmembranei194 – 212HelicalUniRule annotationAdd BLAST19
Transmembranei224 – 245HelicalUniRule annotationAdd BLAST22
Transmembranei257 – 274HelicalUniRule annotationAdd BLAST18

GO - Cellular componenti

Keywords - Cellular componenti

Cell membraneUniRule annotationSAAS annotation, Membrane

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Family and domain databases

HAMAPiMF_01006 Undec_diphosphatase, 1 hit
InterProiView protein in InterPro
IPR003824 UppP
PANTHERiPTHR30622 PTHR30622, 1 hit
PfamiView protein in Pfam
PF02673 BacA, 1 hit
TIGRFAMsiTIGR00753 undec_PP_bacA, 1 hit

Sequencei

Sequence statusi: Complete.

W4V298-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELGVGLIKV IILGIIEGIT EWLPISSTGH MILVEELIKM NMSDEFMEMF
60 70 80 90 100
RVVIQLGAIM AVVVLYWNKL FPFSFKDGVQ IKKDTFSLWI KVLAATLPAA
110 120 130 140 150
LIGIPFDDKI DSLFYNYTTV AITLIVYGIL FIIMENRNKS KISLISTFDE
160 170 180 190 200
LGYKAVLLIG VFQVLALIPG TSRSGATILG AIMIGCSREI AAEFSFYLAI
210 220 230 240 250
PVMFGASLLK LVKFGFAFSQ LELIILFTGM IVAFAISIFA IKFLMGYIKR
260 270
NDFKAFGYYR IILGLIVVLY FLAVR
Length:275
Mass (Da):30,714
Last modified:March 19, 2014 - v1
Checksum:i9FA4350178BE75C3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BAVR01000008 Genomic DNA Translation: GAE87595.1
RefSeqiWP_038287399.1, NZ_BAVR01000008.1

Genome annotation databases

EnsemblBacteriaiGAE87595; GAE87595; JCM21531_980

Similar proteinsi

Entry informationi

Entry nameiW4V298_9FIRM
AccessioniPrimary (citable) accession number: W4V298
Entry historyiIntegrated into UniProtKB/TrEMBL: March 19, 2014
Last sequence update: March 19, 2014
Last modified: November 22, 2017
This is version 23 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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