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Entry version 23 (07 Oct 2020)
Sequence version 1 (19 Mar 2014)
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Protein
Submitted name:

Uncharacterized protein

Gene

PFNF135_05499

Organism
Plasmodium falciparum NF135/5.C10
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:PFNF135_05499Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPlasmodium falciparum NF135/5.C10Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1036726 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaSarAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000019114 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1802 – 1823HelicalSequence analysisAdd BLAST22

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini739 – 791CIDR1_gammaInterPro annotationAdd BLAST53
Domaini808 – 948PFEMPInterPro annotationAdd BLAST141

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni356 – 386DisorderedSequence analysisAdd BLAST31
Regioni440 – 461DisorderedSequence analysisAdd BLAST22
Regioni944 – 1009DisorderedSequence analysisAdd BLAST66
Regioni1776 – 1795DisorderedSequence analysisAdd BLAST20

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili151 – 171Sequence analysisAdd BLAST21
Coiled coili1295 – 1315Sequence analysisAdd BLAST21
Coiled coili1658 – 1678Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi372 – 386PolarSequence analysisAdd BLAST15
Compositional biasi440 – 454PolarSequence analysisAdd BLAST15
Compositional biasi980 – 1003PolyampholyteSequence analysisAdd BLAST24
Compositional biasi1776 – 1791Pro-richSequence analysisAdd BLAST16

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1310.20, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR041480, CIDR1_gamma
IPR004258, DBL
IPR042202, Duffy-ag-bd_sf
IPR008602, Duffy-antigen-binding

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF18562, CIDR1_gamma, 1 hit
PF05424, Duffy_binding, 4 hits
PF03011, PFEMP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

W4I8Y3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMYYTFGDYR DFLFGTDISR KNGDMTKIKN NIDNAFKEKK DNVRKDNNAN
60 70 80 90 100
ETFWEENKKL IWEGMLCGLT YDLTENEKKK ILEDTKYQYD TLTPPLEDFA
110 120 130 140 150
KKPQFLRWMI EWGEEFCAER KKKEEDVETY CTHVNDHDGC NNKAGKCSKA
160 170 180 190 200
CEAYEDYIKK KNKEYTKQEE KFNTDKSNDK EEYNGYSKKK ASEYLKDKCF
210 220 230 240 250
PDRCNCIEKV NSITDYWKNP HETYENSTIK NKCECPKPLP SACSIVETLF
260 270 280 290 300
TTSDKKHINA ACTQKYSGNQ SRLGWKCIPT SGGEKSGSSD SNQGSICIPP
310 320 330 340 350
RRRKLYLGGF DKFISGEATL SSPSHSRDVD LRNAFIQSAA VETFFLWDRY
360 370 380 390 400
KKQKEKPQGE GALGLETLNG GSGDGGEQTP EQQLQSGTIP TDFLRLMFYT
410 420 430 440 450
LGDYRDLCVG VKDNDVIKAL EASSDKNIEK IEQKIKSVIE NSGDTTPPTQ
460 470 480 490 500
TVPPTSDEKR KKWWDENAKD IWEGMICALT YDTNSGGKTI EKVNAANGGE
510 520 530 540 550
DLFEKLKNGN DYETVSFGAS GTGAKGNDDP KLTEFVTRPT FFRWLEEWGE
560 570 580 590 600
EFCKERKKRL ELVKKACREK DDGGDTFCSG DGHDCTDGKR RYNNMFDDLD
610 620 630 640 650
CSDCHEKCTD YKKWIEKKLE EFYKQKSKYP NEYEKLKTSS NSHDDEMFYK
660 670 680 690 700
EVIEKNDYSS VEKFLESLNH CKNRKDNSEQ NNKIDFNEPL KTFSPSTYCK
710 720 730 740 750
SCPLYGVSCD NKGECKPIEE HEFKRKNDLD EIKIKKDTST NIHVQMIDHR
760 770 780 790 800
GQYIQHPLGN SFKESYLFKS VRDQEWTCRF IHNKLDECKL NDFNPKIDTD
810 820 830 840 850
ESITFKVLLE RWLKDFLEGY YISKRKIETC TKKEENKCIK GCKNKCKCVD
860 870 880 890 900
DWLKQKENEW ENIKERYKAY YDSPGYEMAY KVRSYFEKHE SDVKKSIDDY
910 920 930 940 950
EVLKNKDEYE DCNGQNNCTS VDKKRKKDMV TLLLNNLQNE INKCPSSTSV
960 970 980 990 1000
KTSPPCVEPP PGDEEENVED TTTNTKPQFC PKDVEEDKKE PPTIADDKTG
1010 1020 1030 1040 1050
YKRTGGKSNL PTKPSNCVQI GAYEIQQKIN KETKEIKSKV IGNGLLLDKV
1060 1070 1080 1090 1100
CKRVNKNDIS NETCDFNKRY SKFPTTLTNK CNKKGKDRFK IGNLWTCQYI
1110 1120 1130 1140 1150
RILKNDVCIP PRRKEMCIDE FSNIGGYKVS DSNELLKKVQ EAARNEADDI
1160 1170 1180 1190 1200
IRKLLQSNPC NEDLICDALK YSFADLGDII RGRDLLINNT TNDRVERRLR
1210 1220 1230 1240 1250
TIFSKIYNTL GNNAKMKYND ITYYYKLREA WWDTNRKDIW KAMTCAVPED
1260 1270 1280 1290 1300
AKFFKKQPRT QNGPYKYCGH DKDPPYDDNI PQLFRWMTEW SEYFCKVLDK
1310 1320 1330 1340 1350
QMEMVKRECD DCKKNKGTKC NNDEDGDKCK KCKKQCKEYA SLVTKWEKQF
1360 1370 1380 1390 1400
VNQQKIYNEF YKEATIKYSR PETVLFKNRK HTTTTENTKE NIIEFIKAID
1410 1420 1430 1440 1450
TLCSYPKSLN DYLHKKSKCE NFKFLEQYKT EPEYIFSKNP NDYDKACKCT
1460 1470 1480 1490 1500
GPHPLDDCPK NDKNKNPCTN LSIIKECEKK FFNKDNDDWN SQNIPEFTSK
1510 1520 1530 1540 1550
NKGILVPPRR RHLCLRNITA NISSIQNEDD FKNKLIESAY NEGYFLGKTY
1560 1570 1580 1590 1600
AKDKQIILQA MRYSFYDYGD IVKGTDVMDN LKKLHEILKS ILKTENGNNQ
1610 1620 1630 1640 1650
ISHDRKNWWT QNKTHVWHAM LCGYEATQGN FLESDCLLHD DENDQFLRWF
1660 1670 1680 1690 1700
QEWIEHFCTK RNQLYQNLEN QCKHLECNKN DEGTGMTTCK RACQEYSNYI
1710 1720 1730 1740 1750
STKKHEYELL NYQYEKNFMI NLQNKKAPEY YKDKCNNKCN CFSEYFKDET
1760 1770 1780 1790 1800
RWKNPYESFN ESTYKDKCDC QKTVPPPLVP PPPPPKSDEL PAPADEPFDS
1810 1820
TILQTTIPFG VALALGSIAF LFLK
Length:1,824
Mass (Da):212,970
Last modified:March 19, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i94EA3EFDB539A6E7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1824Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
KI926115 Genomic DNA Translation: ETW40126.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
ETW40126; ETW40126; PFNF135_05499

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KI926115 Genomic DNA Translation: ETW40126.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsemblProtistsiETW40126; ETW40126; PFNF135_05499

Family and domain databases

Gene3Di1.20.1310.20, 4 hits
InterProiView protein in InterPro
IPR041480, CIDR1_gamma
IPR004258, DBL
IPR042202, Duffy-ag-bd_sf
IPR008602, Duffy-antigen-binding
PfamiView protein in Pfam
PF18562, CIDR1_gamma, 1 hit
PF05424, Duffy_binding, 4 hits
PF03011, PFEMP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiW4I8Y3_PLAFA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: W4I8Y3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 19, 2014
Last sequence update: March 19, 2014
Last modified: October 7, 2020
This is version 23 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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