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Protein

Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase

Gene

gppA

Organism
Escherichia coli ISC56
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities.UniRule annotationSAAS annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate.UniRule annotationSAAS annotation

Pathwayi: ppGpp biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes ppGpp from GTP.UniRule annotationSAAS annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase (gppA)
This subpathway is part of the pathway ppGpp biosynthesis, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes ppGpp from GTP, the pathway ppGpp biosynthesis and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotationImported

Enzyme and pathway databases

UniPathwayiUPA00908; UER00885

Names & Taxonomyi

Protein namesi
Recommended name:
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphataseUniRule annotationSAAS annotation (EC:3.6.1.40UniRule annotationSAAS annotation)
Alternative name(s):
Guanosine pentaphosphate phosphohydrolaseUniRule annotation
pppGpp-5'-phosphohydrolaseUniRule annotation
Gene namesi
Name:gppAUniRule annotation
OrganismiEscherichia coli ISC56Imported
Taxonomic identifieri1432560 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000019186 Componenti: Unassembled WGS sequence

Structurei

3D structure databases

ProteinModelPortaliW1HJM7
SMRiW1HJM7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 300Ppx-GppAInterPro annotationAdd BLAST281

Sequence similaritiesi

Belongs to the GppA/Ppx family. GppA subfamily.UniRule annotationSAAS annotation

Family and domain databases

HAMAPiMF_01550 GppA, 1 hit
InterProiView protein in InterPro
IPR023709 Guo-5TP_3DP_PyrP
IPR003695 Ppx_GppA
IPR030673 PyroPPase_GppA_Ppx
PfamiView protein in Pfam
PF02541 Ppx-GppA, 1 hit
PIRSFiPIRSF001267 Pyrophosphatase_GppA_Ppx, 1 hit

Sequencei

Sequence statusi: Complete.

W1HJM7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSTSLYAAI DLGSNSFHML VVREVAGSIQ TLSRIKRKVR LAAGLNSDNT
60 70 80 90 100
LSAEAMERGW QCLRLFAERL QDIPPTQIRV VATATLRLAV NAGEFLAKAQ
110 120 130 140 150
EILGTPVQVI SGEEEARLIY QGVAHTTGGA DQRLVVDIGG ASTELVTGTG
160 170 180 190 200
AQTTSLFSLS MGCVTWLERY FADRSLTKEN FDLAEAAARE VLLPVADVLR
210 220 230 240 250
YHGWKVCVGA SGTVQALQEI MMAQGMDERI TLAKLQQLKQ RAIQCGRLEE
260 270 280 290 300
LEIEGLTLER ALVFPSGLAI LIAIFSELNI QCMTLAGGAL REGLVYGMLH
310 320 330 340 350
LSVEQDIRSR TLRNIQRRFM IDTEQAQRVG GLASHLLSQL DGSWELDPLS
360 370 380 390 400
RDLLLSACAL HEIGLSVDFK RAPQHAAYLV NNLDLPGFTP AQKKLIATLL
410 420 430 440 450
LNQTNAIDLS SLHQQNAVPP RVAEHLCRLL RLAILFASRR RDDLLPAIQL
460 470 480 490
TAQDEQLTLI LPGNWLDEHP LGREMVDQEC QWQSYVHWIL RVASGDTLK
Length:499
Mass (Da):55,010
Last modified:March 19, 2014 - v1
Checksum:i1B905D136187C178
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CBWT010001081 Genomic DNA Translation: CDL59128.1

Genome annotation databases

EnsemblBacteriaiCDL59128; CDL59128; CDL59128

Similar proteinsi

Entry informationi

Entry nameiW1HJM7_ECOLX
AccessioniPrimary (citable) accession number: W1HJM7
Entry historyiIntegrated into UniProtKB/TrEMBL: March 19, 2014
Last sequence update: March 19, 2014
Last modified: October 25, 2017
This is version 24 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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