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Protein

Tyrosine-protein kinase

Gene

FER

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase, Tyrosine-protein kinaseUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinaseUniRule annotation (EC:2.7.10.2UniRule annotation)
Gene namesi
Name:FERImported
Synonyms:Pe1Fe10Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000151422.12
HGNCiHGNC:3655 FER

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000151422

Expressioni

Gene expression databases

BgeeiENSG00000151422

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

SMRiW0S4B9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini49 – 139SH2InterPro annotationAdd BLAST91
Domaini152 – 405Protein kinaseInterPro annotationAdd BLAST254

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.UniRule annotationSAAS annotation

Keywords - Domaini

SH2 domainPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0194 Eukaryota
ENOG410Y6RP LUCA
GeneTreeiENSGT00760000119011

Family and domain databases

CDDicd10361 SH2_Fps_family, 1 hit
Gene3Di3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR028539 Fer
IPR035849 Fes/Fps/Fer_SH2
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
PANTHERiPTHR24418:SF227 PTHR24418:SF227, 1 hit
PfamiView protein in Pfam
PF07714 Pkinase_Tyr, 1 hit
PF00017 SH2, 1 hit
PRINTSiPR00401 SH2DOMAIN
PR00109 TYRKINASE
SMARTiView protein in SMART
SM00252 SH2, 1 hit
SM00219 TyrKc, 1 hit
SUPFAMiSSF55550 SSF55550, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS50001 SH2, 1 hit

Sequencei

Sequence statusi: Complete.

W0S4B9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERKERLSKF ESIRHSIAGI IRSPKSALGS SALSDMISIS EKPLAEQDWY
60 70 80 90 100
HGAIPRIEAQ ELLKKQGDFL VRESHGKPGE YVLSVYSDGQ RRHFIIQYVD
110 120 130 140 150
NMYRFEGTGF SNIPQLIDHH YTTKQVITKK SGVVLLNPIP KDKKWILSHE
160 170 180 190 200
DVILGELLGK GNFGEVYKGT LKDKTSVAVK TCKEDLPQEL KIKFLQEAKI
210 220 230 240 250
LKQYDHPNIV KLIGVCTQRQ PVYIIMELVS GGDFLTFLRR KKDELKLKQL
260 270 280 290 300
VKFSLDAAAG MLYLESKNCI HRDLAARNCL VGENNVLKIS DFGMSRQEDG
310 320 330 340 350
GVYSSSGLKQ IPIKWTAPEA LNYGRYSSES DVWSFGILLW ETFSLGVCPY
360 370 380 390 400
PGMTNQQARE QVERGYRMSA PQHCPEDISK IMMKCWDYKP ENRPKFSELQ
410
KELTIIKRKL T
Length:411
Mass (Da):46,954
Last modified:March 19, 2014 - v1
Checksum:i9643057F49DF8753
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008871 Genomic DNA No translation available.
AC008955 Genomic DNA No translation available.
AC010228 Genomic DNA No translation available.
AC011421 Genomic DNA No translation available.
AC034207 Genomic DNA No translation available.
AC109481 Genomic DNA No translation available.
KF457961 Genomic DNA No translation available.
KF457967 Genomic DNA No translation available.
AB636594 mRNA Translation: BAO24703.1

Genome annotation databases

EnsembliENST00000438717; ENSP00000394297; ENSG00000151422
UCSCiuc063fwl.1 human

Similar proteinsi

Entry informationi

Entry nameiW0S4B9_HUMAN
AccessioniPrimary (citable) accession number: W0S4B9
Entry historyiIntegrated into UniProtKB/TrEMBL: March 19, 2014
Last sequence update: March 19, 2014
Last modified: June 20, 2018
This is version 44 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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