UniProtKB - W0S0X4 (W0S0X4_HUMAN)
Protein
Tyrosine-protein kinase
Gene
Pe1Fe3
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
- ATP + L-tyrosyl-[protein] = ADP + H+ + O-phospho-L-tyrosyl-[protein]UniRule annotationARBA annotationEC:2.7.10.2UniRule annotationARBA annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 591 | ATPUniRule annotation | 1 | |
Active sitei | 684 | Proton acceptorUniRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 569 – 577 | ATPUniRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- epidermal growth factor receptor binding Source: InterPro
- lipid binding Source: UniProtKB-KW
- non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC
- protein phosphatase 1 binding Source: Ensembl
GO - Biological processi
- actin cytoskeleton reorganization Source: Ensembl
- cell-cell adhesion mediated by cadherin Source: Ensembl
- cell population proliferation Source: InterPro
- cellular response to reactive oxygen species Source: Ensembl
- chemotaxis Source: Ensembl
- diapedesis Source: Ensembl
- extracellular matrix-cell signaling Source: Ensembl
- Fc-epsilon receptor signaling pathway Source: Ensembl
- insulin receptor signaling pathway via phosphatidylinositol 3-kinase Source: Ensembl
- Kit signaling pathway Source: Ensembl
- negative regulation of mast cell activation involved in immune response Source: Ensembl
- platelet-derived growth factor receptor signaling pathway Source: Ensembl
- positive regulation of cell migration Source: InterPro
- positive regulation of NF-kappaB transcription factor activity Source: InterPro
- protein autophosphorylation Source: Ensembl
- regulation of epidermal growth factor receptor signaling pathway Source: InterPro
- regulation of fibroblast migration Source: Ensembl
- regulation of protein phosphorylation Source: Ensembl
- response to lipopolysaccharide Source: Ensembl
- response to platelet-derived growth factor Source: Ensembl
- substrate adhesion-dependent cell spreading Source: Ensembl
Keywordsi
Molecular function | Kinase, Transferase, Tyrosine-protein kinaseUniRule annotationARBA annotation |
Ligand | ATP-bindingUniRule annotationARBA annotation, Lipid-bindingARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:Pe1Fe3Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000151422.12 |
Subcellular locationi
Plasma membrane
- Cell membrane ARBA annotation; Peripheral membrane protein ARBA annotation; Cytoplasmic side ARBA annotation
Cytoskeleton
- cytoskeleton UniRule annotation
Cytoskeleton
- cytoskeleton Source: UniProtKB-SubCell
Cytosol
- cytosol Source: HPA
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- cell junction Source: UniProtKB-KW
Keywords - Cellular componenti
Cell junctionARBA annotation, Cytoplasm, CytoskeletonUniRule annotationExpressioni
Gene expression databases
Bgeei | ENSG00000151422, Expressed in corpus callosum and 228 other tissues |
ExpressionAtlasi | W0S0X4, baseline and differential |
Interactioni
GO - Molecular functioni
- epidermal growth factor receptor binding Source: InterPro
- protein phosphatase 1 binding Source: Ensembl
Chemistry databases
BindingDBi | W0S0X4 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 259 | F-BARInterPro annotationAdd BLAST | 259 | |
Domaini | 460 – 550 | SH2InterPro annotationAdd BLAST | 91 | |
Domaini | 563 – 816 | Protein kinaseInterPro annotationAdd BLAST | 254 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 126 – 167 | Sequence analysisAdd BLAST | 42 | |
Coiled coili | 302 – 343 | Sequence analysisAdd BLAST | 42 | |
Coiled coili | 353 – 380 | Sequence analysisAdd BLAST | 28 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.UniRule annotation
Keywords - Domaini
Coiled coilPROSITE-ProRule annotationARBA annotation, SH2 domainPROSITE-ProRule annotationPhylogenomic databases
HOGENOMi | CLU_005265_0_0_1 |
OMAi | YVLAVCG |
OrthoDBi | 556386at2759 |
PhylomeDBi | W0S0X4 |
Family and domain databases
CDDi | cd07686, F-BAR_Fer, 1 hit cd10361, SH2_Fps_family, 1 hit |
Gene3Di | 1.20.1270.60, 1 hit 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR027267, AH/BAR_dom_sf IPR031160, F_BAR IPR001060, FCH_dom IPR028539, Fer IPR037452, Fer_F-BAR IPR035849, Fes/Fps/Fer_SH2 IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR000980, SH2 IPR036860, SH2_dom_sf IPR016250, Tyr-prot_kinase_Fes/Fps IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom |
PANTHERi | PTHR24418:SF227, PTHR24418:SF227, 1 hit |
Pfami | View protein in Pfam PF00611, FCH, 1 hit PF07714, PK_Tyr_Ser-Thr, 1 hit PF00017, SH2, 1 hit |
PIRSFi | PIRSF000632, TyrPK_fps, 1 hit |
PRINTSi | PR00401, SH2DOMAIN PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00055, FCH, 1 hit SM00252, SH2, 1 hit SM00219, TyrKc, 1 hit |
SUPFAMi | SSF103657, SSF103657, 1 hit SSF55550, SSF55550, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS51741, F_BAR, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit PS50001, SH2, 1 hit |
i Sequence
Sequence statusi: Complete.
W0S0X4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGFGSDLKNS HEAVLKLQDW ELRLLETVKK FMALRIKSDK EYASTLQNLC
60 70 80 90 100
NQVDKESTVQ MNYVSNVSKS WLLMIQQTEQ LSRIMKTHAE DLNSGPLHRL
110 120 130 140 150
TMMIKDKQQV KKSYIGVHQQ IEAEMIKVTK TELEKLKCSY RQLIKEMNSA
160 170 180 190 200
KEKYKEALAK GKETEKAKER YDKATMKLHM LHNQYVLALK GAQLHQNQYY
210 220 230 240 250
DITLPLLLDS LQKMQEEMIK ALKGIFDEYS QITSLVTEEI VNVHKEIQMS
260 270 280 290 300
VEQIDPSTEY NNFIDVHRTT AAKEQEIEFD TSLLEENENL QANEIMWNNL
310 320 330 340 350
TAESLQVMLK TLAEELMQTQ QMLLNKEEAV LELEKRIEES SETCEKKSDI
360 370 380 390 400
VLLLSQKQAL EELKQSVQQL RCTEAKFSAQ KELLEQKVQE NDGKEPPPVV
410 420 430 440 450
NYEEDARSVT SMERKERLSK FESIRHSIAG IIRSPKSALG SSALSDMISI
460 470 480 490 500
SEKPLAEQDW YHGAIPRIEA QELLKKQGDF LVRESHGKPG EYVLSVYSDG
510 520 530 540 550
QRRHFIIQYV DNMYRFEGTG FSNIPQLIDH HYTTKQVITK KSGVVLLNPI
560 570 580 590 600
PKDKKWILSH EDVILGELLG KGNFGEVYKG TLKDKTSVAV KTCKEDLPQE
610 620 630 640 650
LKIKFLQEAK ILKQYDHPNI VKLIGVCTQR QPVYIIMELV SGGDFLTFLR
660 670 680 690 700
RKKDELKLKQ LVKFSLDAAA GMLYLESKNC IHRDLAARNC LVGENNVLKI
710 720 730 740 750
SDFGMSRQED GGVYSSSGLK QIPIKWTAPE ALNYGRYSSE SDVWSFGILL
760 770 780 790 800
WETFSLGVCP YPGMTNQQAR EQVERGYRMS APQHCPEDIS KIMMKCWDYK
810 820
PENRPKFSEL QKELTIIKRK LT
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB636592 mRNA Translation: BAO24701.1 |
RefSeqi | NP_005237.2, NM_005246.3 XP_011541573.1, XM_011543271.2 XP_016864719.1, XM_017009230.1 XP_016864720.1, XM_017009231.1 |
Genome annotation databases
GeneIDi | 2241 |
KEGGi | hsa:2241 |
UCSCi | uc003kop.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB636592 mRNA Translation: BAO24701.1 |
RefSeqi | NP_005237.2, NM_005246.3 XP_011541573.1, XM_011543271.2 XP_016864719.1, XM_017009230.1 XP_016864720.1, XM_017009231.1 |
3D structure databases
SMRi | W0S0X4 |
ModBasei | Search... |
Chemistry databases
BindingDBi | W0S0X4 |
Proteomic databases
MaxQBi | W0S0X4 |
Protocols and materials databases
Antibodypediai | 2083, 566 antibodies |
Genome annotation databases
GeneIDi | 2241 |
KEGGi | hsa:2241 |
UCSCi | uc003kop.2, human |
Organism-specific databases
CTDi | 2241 |
VEuPathDBi | HostDB:ENSG00000151422.12 |
Phylogenomic databases
HOGENOMi | CLU_005265_0_0_1 |
OMAi | YVLAVCG |
OrthoDBi | 556386at2759 |
PhylomeDBi | W0S0X4 |
Miscellaneous databases
BioGRID-ORCSi | 2241, 9 hits in 906 CRISPR screens |
GenomeRNAii | 2241 |
Gene expression databases
Bgeei | ENSG00000151422, Expressed in corpus callosum and 228 other tissues |
ExpressionAtlasi | W0S0X4, baseline and differential |
Family and domain databases
CDDi | cd07686, F-BAR_Fer, 1 hit cd10361, SH2_Fps_family, 1 hit |
Gene3Di | 1.20.1270.60, 1 hit 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR027267, AH/BAR_dom_sf IPR031160, F_BAR IPR001060, FCH_dom IPR028539, Fer IPR037452, Fer_F-BAR IPR035849, Fes/Fps/Fer_SH2 IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR000980, SH2 IPR036860, SH2_dom_sf IPR016250, Tyr-prot_kinase_Fes/Fps IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom |
PANTHERi | PTHR24418:SF227, PTHR24418:SF227, 1 hit |
Pfami | View protein in Pfam PF00611, FCH, 1 hit PF07714, PK_Tyr_Ser-Thr, 1 hit PF00017, SH2, 1 hit |
PIRSFi | PIRSF000632, TyrPK_fps, 1 hit |
PRINTSi | PR00401, SH2DOMAIN PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00055, FCH, 1 hit SM00252, SH2, 1 hit SM00219, TyrKc, 1 hit |
SUPFAMi | SSF103657, SSF103657, 1 hit SSF55550, SSF55550, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS51741, F_BAR, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit PS50001, SH2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | W0S0X4_HUMAN | |
Accessioni | W0S0X4Primary (citable) accession number: W0S0X4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 19, 2014 |
Last sequence update: | March 19, 2014 | |
Last modified: | February 10, 2021 | |
This is version 59 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |