Pe1Fe3

Functionⁱ

Catalytic activityⁱ

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	591	ATPUniRule annotation		1
Active siteⁱ	684	Proton acceptorUniRule annotation		1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	569 – 577	ATPUniRule annotation		9

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
epidermal growth factor receptor binding Source: InterPro
non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC
protein phosphatase 1 binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

actin cytoskeleton reorganization Source: Ensembl
cell-cell adhesion mediated by cadherin Source: Ensembl
cell proliferation Source: InterPro
cellular response to reactive oxygen species Source: Ensembl
chemotaxis Source: Ensembl
diapedesis Source: Ensembl
extracellular matrix-cell signaling Source: Ensembl
Fc-epsilon receptor signaling pathway Source: Ensembl
insulin receptor signaling pathway via phosphatidylinositol 3-kinase Source: Ensembl
Kit signaling pathway Source: Ensembl
negative regulation of mast cell activation involved in immune response Source: Ensembl
platelet-derived growth factor receptor signaling pathway Source: Ensembl
positive regulation of cell migration Source: InterPro
positive regulation of NF-kappaB transcription factor activity Source: InterPro
protein autophosphorylation Source: Ensembl
regulation of epidermal growth factor receptor signaling pathway Source: InterPro
regulation of fibroblast migration Source: Ensembl
regulation of protein phosphorylation Source: Ensembl
response to lipopolysaccharide Source: Ensembl
response to platelet-derived growth factor Source: Ensembl
substrate adhesion-dependent cell spreading Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, Transferase, Tyrosine-protein kinaseUniRule annotationSAAS annotation
Ligand	ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Tyrosine-protein kinaseUniRule annotation (EC:2.7.10.2UniRule annotation)
Gene namesⁱ	Name:Pe1Fe3Imported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000151422.12

EuPathDBⁱ

HostDB:ENSG00000151422.12

Keywords - Cellular componentⁱ

Cytoplasm, CytoskeletonUniRule annotation

PTM / Processingⁱ

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	W0S0X4

MaxQBⁱ

W0S0X4

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000151422 Expressed in 213 organ(s), highest expression level in corpus callosum
ExpressionAtlasⁱ	W0S0X4 baseline and differential

Interactionⁱ

GO - Molecular functionⁱ

epidermal growth factor receptor binding Source: InterPro
protein phosphatase 1 binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	W0S0X4
SMRⁱ	W0S0X4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	1 – 259	F-BARInterPro annotationAdd BLAST	259
Domainⁱ	460 – 550	SH2InterPro annotationAdd BLAST	91
Domainⁱ	563 – 816	Protein kinaseInterPro annotationAdd BLAST	254

Coiled coil

Feature key	Position(s)	DescriptionActions	Length
Coiled coilⁱ	126 – 167	Sequence analysisAdd BLAST	42
Coiled coilⁱ	302 – 343	Sequence analysisAdd BLAST	42
Coiled coilⁱ	353 – 380	Sequence analysisAdd BLAST	28

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.UniRule annotation

Keywords - Domainⁱ

Coiled coilPROSITE-ProRule annotation, SH2 domainPROSITE-ProRule annotation

Phylogenomic databases

eggNOGⁱ	KOG0194 Eukaryota ENOG410Y6RP LUCA
KEGG Orthology (KO) More...KOⁱ	K08889
OMAⁱ	QFADNLY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G01S4
PhylomeDBⁱ	W0S0X4

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd07686 F-BAR_Fer, 1 hit cd10361 SH2_Fps_family, 1 hit
Gene3Dⁱ	1.20.1270.60, 1 hit 3.30.505.10, 1 hit
InterProⁱ	View protein in InterPro IPR027267 AH/BAR_dom_sf IPR031160 F_BAR IPR001060 FCH_dom IPR028539 Fer IPR037452 Fer_F-BAR IPR035849 Fes/Fps/Fer_SH2 IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR001245 Ser-Thr/Tyr_kinase_cat_dom IPR000980 SH2 IPR036860 SH2_dom_sf IPR016250 Tyr-prot_kinase_Fes/Fps IPR008266 Tyr_kinase_AS IPR020635 Tyr_kinase_cat_dom
PANTHERⁱ	PTHR24418:SF227 PTHR24418:SF227, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00611 FCH, 1 hit PF07714 Pkinase_Tyr, 1 hit PF00017 SH2, 1 hit
PIRSFⁱ	PIRSF000632 TyrPK_fps, 1 hit
PRINTSⁱ	PR00401 SH2DOMAIN PR00109 TYRKINASE
SMARTⁱ	View protein in SMART SM00055 FCH, 1 hit SM00252 SH2, 1 hit SM00219 TyrKc, 1 hit
SUPFAMⁱ	SSF103657 SSF103657, 1 hit SSF55550 SSF55550, 1 hit SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS51741 F_BAR, 1 hit PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00109 PROTEIN_KINASE_TYR, 1 hit PS50001 SH2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

W0S0X4-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGFGSDLKNS HEAVLKLQDW ELRLLETVKK FMALRIKSDK EYASTLQNLC 
        60         70         80         90        100
NQVDKESTVQ MNYVSNVSKS WLLMIQQTEQ LSRIMKTHAE DLNSGPLHRL 
       110        120        130        140        150
TMMIKDKQQV KKSYIGVHQQ IEAEMIKVTK TELEKLKCSY RQLIKEMNSA 
       160        170        180        190        200
KEKYKEALAK GKETEKAKER YDKATMKLHM LHNQYVLALK GAQLHQNQYY 
       210        220        230        240        250
DITLPLLLDS LQKMQEEMIK ALKGIFDEYS QITSLVTEEI VNVHKEIQMS 
       260        270        280        290        300
VEQIDPSTEY NNFIDVHRTT AAKEQEIEFD TSLLEENENL QANEIMWNNL 
       310        320        330        340        350
TAESLQVMLK TLAEELMQTQ QMLLNKEEAV LELEKRIEES SETCEKKSDI 
       360        370        380        390        400
VLLLSQKQAL EELKQSVQQL RCTEAKFSAQ KELLEQKVQE NDGKEPPPVV 
       410        420        430        440        450
NYEEDARSVT SMERKERLSK FESIRHSIAG IIRSPKSALG SSALSDMISI 
       460        470        480        490        500
SEKPLAEQDW YHGAIPRIEA QELLKKQGDF LVRESHGKPG EYVLSVYSDG 
       510        520        530        540        550
QRRHFIIQYV DNMYRFEGTG FSNIPQLIDH HYTTKQVITK KSGVVLLNPI 
       560        570        580        590        600
PKDKKWILSH EDVILGELLG KGNFGEVYKG TLKDKTSVAV KTCKEDLPQE 
       610        620        630        640        650
LKIKFLQEAK ILKQYDHPNI VKLIGVCTQR QPVYIIMELV SGGDFLTFLR 
       660        670        680        690        700
RKKDELKLKQ LVKFSLDAAA GMLYLESKNC IHRDLAARNC LVGENNVLKI 
       710        720        730        740        750
SDFGMSRQED GGVYSSSGLK QIPIKWTAPE ALNYGRYSSE SDVWSFGILL 
       760        770        780        790        800
WETFSLGVCP YPGMTNQQAR EQVERGYRMS APQHCPEDIS KIMMKCWDYK 
       810        820 
PENRPKFSEL QKELTIIKRK LT

Length:822

Mass (Da):94,638

Last modified:March 19, 2014 - v1

Checksum:ⁱBD42DF6C03419C76

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB636592 mRNA Translation: BAO24701.1
NCBI Reference Sequences More...RefSeqⁱ	NP_005237.2, NM_005246.3 XP_011541573.1, XM_011543271.2 XP_016864719.1, XM_017009230.1 XP_016864720.1, XM_017009231.1
UniGeneⁱ	Hs.107418 Hs.221472 Hs.625304

Genome annotation databases

GeneIDⁱ	2241
KEGGⁱ	hsa:2241
UCSC genome browser More...UCSCⁱ	uc003kop.2 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
W0S0X4	Tyrosine-protein kinase Fer	)	HUMAN		822	UniRef100_P16591
Tyrosine-protein kinase		PANTR		822
Tyrosine-protein kinase		GORGO		822
Truncated fer (Fps/fes related) tyrosine kinase		HUMAN		310
Tyrosine-protein kinase		HUMAN		411
+5

Protein	Similar proteins		Species	Score	Length	Source
W0S0X4	Tyrosine-protein kinase Fer		MOUSE		823	UniRef90_P70451
Tyrosine-protein kinase Fer		CANLF		823
Tyrosine-protein kinase Fer		RAT		823
Tyrosine-protein kinase Fer	)	HUMAN		822
Tyrosine-protein kinase		SHEEP		825
+169

Protein	Similar proteins		Species	Score	Length	Source
W0S0X4	Tyrosine-protein kinase Fer		MOUSE		823	UniRef50_P70451
Tyrosine-protein kinase Fer		CANLF		823
Tyrosine-protein kinase Fer		RAT		823
Tyrosine-protein kinase Fer	)	HUMAN		822
Tyrosine-protein kinase		SHEEP		825
+432

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB636592 mRNA Translation: BAO24701.1
RefSeqⁱ	NP_005237.2, NM_005246.3 XP_011541573.1, XM_011543271.2 XP_016864719.1, XM_017009230.1 XP_016864720.1, XM_017009231.1
UniGeneⁱ	Hs.107418 Hs.221472 Hs.625304

3D structure databases

ProteinModelPortalⁱ	W0S0X4
SMRⁱ	W0S0X4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

MaxQBⁱ	W0S0X4

MaxQBⁱ

W0S0X4

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	2241
KEGGⁱ	hsa:2241
UCSCⁱ	uc003kop.2 human

Organism-specific databases

CTDⁱ	2241
EuPathDBⁱ	HostDB:ENSG00000151422.12

Phylogenomic databases

eggNOGⁱ	KOG0194 Eukaryota ENOG410Y6RP LUCA
KOⁱ	K08889
OMAⁱ	QFADNLY
OrthoDBⁱ	EOG091G01S4
PhylomeDBⁱ	W0S0X4

Miscellaneous databases

GenomeRNAiⁱ	2241

GenomeRNAiⁱ

2241

Gene expression databases

Bgeeⁱ	ENSG00000151422 Expressed in 213 organ(s), highest expression level in corpus callosum
ExpressionAtlasⁱ	W0S0X4 baseline and differential

Family and domain databases

CDDⁱ	cd07686 F-BAR_Fer, 1 hit cd10361 SH2_Fps_family, 1 hit
Gene3Dⁱ	1.20.1270.60, 1 hit 3.30.505.10, 1 hit
InterProⁱ	View protein in InterPro IPR027267 AH/BAR_dom_sf IPR031160 F_BAR IPR001060 FCH_dom IPR028539 Fer IPR037452 Fer_F-BAR IPR035849 Fes/Fps/Fer_SH2 IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR001245 Ser-Thr/Tyr_kinase_cat_dom IPR000980 SH2 IPR036860 SH2_dom_sf IPR016250 Tyr-prot_kinase_Fes/Fps IPR008266 Tyr_kinase_AS IPR020635 Tyr_kinase_cat_dom
PANTHERⁱ	PTHR24418:SF227 PTHR24418:SF227, 1 hit
Pfamⁱ	View protein in Pfam PF00611 FCH, 1 hit PF07714 Pkinase_Tyr, 1 hit PF00017 SH2, 1 hit
PIRSFⁱ	PIRSF000632 TyrPK_fps, 1 hit
PRINTSⁱ	PR00401 SH2DOMAIN PR00109 TYRKINASE
SMARTⁱ	View protein in SMART SM00055 FCH, 1 hit SM00252 SH2, 1 hit SM00219 TyrKc, 1 hit
SUPFAMⁱ	SSF103657 SSF103657, 1 hit SSF55550 SSF55550, 1 hit SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS51741 F_BAR, 1 hit PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00109 PROTEIN_KINASE_TYR, 1 hit PS50001 SH2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	W0S0X4_HUMAN
Accessionⁱ	W0S0X4Primary (citable) accession number: W0S0X4
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	March 19, 2014
	Last sequence update:	March 19, 2014
	Last modified:	September 12, 2018
	This is version 45 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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UniProtKB - W0S0X4 (W0S0X4_HUMAN)

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Tyrosine-protein kinase

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Cytoskeleton

Cytosol

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ