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Protein

Tyrosine-protein kinase

Gene

Pe1Fe3

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei591ATPUniRule annotation1
Active sitei684Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi569 – 577ATPUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase, Tyrosine-protein kinaseUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinaseUniRule annotation (EC:2.7.10.2UniRule annotation)
Gene namesi
Name:Pe1Fe3Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000151422.12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, CytoskeletonUniRule annotation

PTM / Processingi

Proteomic databases

MaxQBiW0S0X4

Expressioni

Gene expression databases

BgeeiENSG00000151422
ExpressionAtlasiW0S0X4 baseline and differential

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliW0S0X4
SMRiW0S0X4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 259F-BARInterPro annotationAdd BLAST259
Domaini460 – 550SH2InterPro annotationAdd BLAST91
Domaini563 – 816Protein kinaseInterPro annotationAdd BLAST254

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili126 – 167Sequence analysisAdd BLAST42
Coiled coili302 – 343Sequence analysisAdd BLAST42
Coiled coili353 – 380Sequence analysisAdd BLAST28

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.UniRule annotation

Keywords - Domaini

Coiled coilPROSITE-ProRule annotation, SH2 domainPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0194 Eukaryota
ENOG410Y6RP LUCA
KOiK08889
OMAiQFADNLY
OrthoDBiEOG091G01S4
PhylomeDBiW0S0X4

Family and domain databases

CDDicd07686 F-BAR_Fer, 1 hit
cd10361 SH2_Fps_family, 1 hit
Gene3Di1.20.1270.60, 1 hit
3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR031160 F_BAR
IPR001060 FCH_dom
IPR028539 Fer
IPR037452 Fer_F-BAR
IPR035849 Fes/Fps/Fer_SH2
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR016250 Tyr-prot_kinase_Fes/Fps
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
PANTHERiPTHR24418:SF227 PTHR24418:SF227, 1 hit
PfamiView protein in Pfam
PF00611 FCH, 1 hit
PF07714 Pkinase_Tyr, 1 hit
PF00017 SH2, 1 hit
PIRSFiPIRSF000632 TyrPK_fps, 1 hit
PRINTSiPR00401 SH2DOMAIN
PR00109 TYRKINASE
SMARTiView protein in SMART
SM00055 FCH, 1 hit
SM00252 SH2, 1 hit
SM00219 TyrKc, 1 hit
SUPFAMiSSF103657 SSF103657, 1 hit
SSF55550 SSF55550, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51741 F_BAR, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS50001 SH2, 1 hit

Sequencei

Sequence statusi: Complete.

W0S0X4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGFGSDLKNS HEAVLKLQDW ELRLLETVKK FMALRIKSDK EYASTLQNLC
60 70 80 90 100
NQVDKESTVQ MNYVSNVSKS WLLMIQQTEQ LSRIMKTHAE DLNSGPLHRL
110 120 130 140 150
TMMIKDKQQV KKSYIGVHQQ IEAEMIKVTK TELEKLKCSY RQLIKEMNSA
160 170 180 190 200
KEKYKEALAK GKETEKAKER YDKATMKLHM LHNQYVLALK GAQLHQNQYY
210 220 230 240 250
DITLPLLLDS LQKMQEEMIK ALKGIFDEYS QITSLVTEEI VNVHKEIQMS
260 270 280 290 300
VEQIDPSTEY NNFIDVHRTT AAKEQEIEFD TSLLEENENL QANEIMWNNL
310 320 330 340 350
TAESLQVMLK TLAEELMQTQ QMLLNKEEAV LELEKRIEES SETCEKKSDI
360 370 380 390 400
VLLLSQKQAL EELKQSVQQL RCTEAKFSAQ KELLEQKVQE NDGKEPPPVV
410 420 430 440 450
NYEEDARSVT SMERKERLSK FESIRHSIAG IIRSPKSALG SSALSDMISI
460 470 480 490 500
SEKPLAEQDW YHGAIPRIEA QELLKKQGDF LVRESHGKPG EYVLSVYSDG
510 520 530 540 550
QRRHFIIQYV DNMYRFEGTG FSNIPQLIDH HYTTKQVITK KSGVVLLNPI
560 570 580 590 600
PKDKKWILSH EDVILGELLG KGNFGEVYKG TLKDKTSVAV KTCKEDLPQE
610 620 630 640 650
LKIKFLQEAK ILKQYDHPNI VKLIGVCTQR QPVYIIMELV SGGDFLTFLR
660 670 680 690 700
RKKDELKLKQ LVKFSLDAAA GMLYLESKNC IHRDLAARNC LVGENNVLKI
710 720 730 740 750
SDFGMSRQED GGVYSSSGLK QIPIKWTAPE ALNYGRYSSE SDVWSFGILL
760 770 780 790 800
WETFSLGVCP YPGMTNQQAR EQVERGYRMS APQHCPEDIS KIMMKCWDYK
810 820
PENRPKFSEL QKELTIIKRK LT
Length:822
Mass (Da):94,638
Last modified:March 19, 2014 - v1
Checksum:iBD42DF6C03419C76
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB636592 mRNA Translation: BAO24701.1
RefSeqiNP_005237.2, NM_005246.3
XP_011541573.1, XM_011543271.2
XP_016864719.1, XM_017009230.1
XP_016864720.1, XM_017009231.1
UniGeneiHs.107418
Hs.221472
Hs.625304

Genome annotation databases

GeneIDi2241
KEGGihsa:2241
UCSCiuc003kop.2 human

Similar proteinsi

Entry informationi

Entry nameiW0S0X4_HUMAN
AccessioniPrimary (citable) accession number: W0S0X4
Entry historyiIntegrated into UniProtKB/TrEMBL: March 19, 2014
Last sequence update: March 19, 2014
Last modified: March 28, 2018
This is version 44 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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