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Protein

Mediator of RNA polymerase II transcription subunit 6

Gene
N/A
Organism
Callorhinchus milii (Ghost shark)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivatorUniRule annotation
Biological processTranscription, Transcription regulationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Mediator of RNA polymerase II transcription subunit 6UniRule annotation
Alternative name(s):
Mediator complex subunit 6UniRule annotation
OrganismiCallorhinchus milii (Ghost shark)Imported
Taxonomic identifieri7868 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataChondrichthyesHolocephaliChimaeriformesCallorhinchidaeCallorhinchus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

Interactioni

Subunit structurei

Component of the Mediator complex.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the Mediator complex subunit 6 family.UniRule annotation

Phylogenomic databases

KOiK15128
OrthoDBiEOG091G0MJA

Family and domain databases

Gene3Di3.10.450.580, 1 hit
InterProiView protein in InterPro
IPR038566 Med6_sf
IPR007018 Mediator_Med6
IPR016820 Mediator_Med6_met/pln
PANTHERiPTHR13104 PTHR13104, 1 hit
PfamiView protein in Pfam
PF04934 Med6, 1 hit
PIRSFiPIRSF023869 Mediator_MED6_meta/pln, 1 hit

Sequencei

Sequence statusi: Complete.

V9KPX5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAAAAAVAA AENRDNLLGI SWVDSAWIPI LNPVNVLDYF SERSNPFYDR
60 70 80 90 100
TCNNEVVKMQ RLSLDHLHNM TGLEYILLHA QEPILYIIRK QHRYSAIQVT
110 120 130 140 150
PLADYYIIAG VVYQAPDLGS VINSRMLTAV HAIQSAFDES MSYCRYHPSK
160 170 180 190 200
GYWWHFKDQE ERDKVKPKSK KKEEPSSLFQ RQRVDMLLLD LRQKFQPKFI
210 220 230 240 250
QPKRGEKPVP VEQIKKEPEP IAETVKQEEK DTTKSSQQSS TVKAPPEKRM

RLQ
Length:253
Mass (Da):29,257
Last modified:March 19, 2014 - v1
Checksum:iF6296581A38E80B3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JW867613 mRNA Translation: AFP00131.1
RefSeqiXP_007891615.1, XM_007893424.1

Genome annotation databases

GeneIDi103178587
KEGGicmk:103178587

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JW867613 mRNA Translation: AFP00131.1
RefSeqiXP_007891615.1, XM_007893424.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi103178587
KEGGicmk:103178587

Organism-specific databases

CTDi10001

Phylogenomic databases

KOiK15128
OrthoDBiEOG091G0MJA

Family and domain databases

Gene3Di3.10.450.580, 1 hit
InterProiView protein in InterPro
IPR038566 Med6_sf
IPR007018 Mediator_Med6
IPR016820 Mediator_Med6_met/pln
PANTHERiPTHR13104 PTHR13104, 1 hit
PfamiView protein in Pfam
PF04934 Med6, 1 hit
PIRSFiPIRSF023869 Mediator_MED6_meta/pln, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiV9KPX5_CALMI
AccessioniPrimary (citable) accession number: V9KPX5
Entry historyiIntegrated into UniProtKB/TrEMBL: March 19, 2014
Last sequence update: March 19, 2014
Last modified: November 7, 2018
This is version 19 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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