UniProtKB - V9HWA5 (V9HWA5_HUMAN)
Protein
Calponin
Gene
HEL-S-14
Organism
Homo sapiens (Human)
Status
Functioni
Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.UniRule annotation
GO - Molecular functioni
- actin binding Source: UniProtKB-KW
- calmodulin binding Source: UniProtKB-KW
GO - Biological processi
- actomyosin structure organization Source: InterPro
Keywordsi
Molecular function | Actin-bindingUniRule annotationARBA annotation, Calmodulin-bindingUniRule annotation |
Names & Taxonomyi
Protein namesi | Recommended name: CalponinUniRule annotation |
Gene namesi | Name:HEL-S-14Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000130176.7 |
Expressioni
Gene expression databases
Bgeei | ENSG00000130176, Expressed in lower esophagus muscularis layer and 193 other tissues |
ExpressionAtlasi | V9HWA5, baseline and differential |
Interactioni
GO - Molecular functioni
- actin binding Source: UniProtKB-KW
- calmodulin binding Source: UniProtKB-KW
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 28 – 131 | Calponin-homology (CH)InterPro annotationAdd BLAST | 104 |
Sequence similaritiesi
Keywords - Domaini
RepeatARBA annotationPhylogenomic databases
OMAi | GEPTHNH |
OrthoDBi | 861989at2759 |
PhylomeDBi | V9HWA5 |
Family and domain databases
CDDi | cd00014, CH, 1 hit |
Gene3Di | 1.10.418.10, 1 hit |
InterProi | View protein in InterPro IPR001997, Calponin/LIMCH1 IPR000557, Calponin_repeat IPR001715, CH-domain IPR036872, CH_dom_sf IPR003096, SM22_calponin |
Pfami | View protein in Pfam PF00402, Calponin, 3 hits PF00307, CH, 1 hit |
PRINTSi | PR00889, CALPONIN PR00888, SM22CALPONIN |
SMARTi | View protein in SMART SM00033, CH, 1 hit |
SUPFAMi | SSF47576, SSF47576, 1 hit |
PROSITEi | View protein in PROSITE PS01052, CALPONIN_1, 2 hits PS51122, CALPONIN_2, 3 hits PS50021, CH, 1 hit |
i Sequence
Sequence statusi: Complete.
V9HWA5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSAHFNRGP AYGLSAEVKN KLAQKYDHQR EQELREWIEG VTGRRIGNNF
60 70 80 90 100
MDGLKDGIIL CEFINKLQPG SVKKINESTQ NWHQLENIGN FIKAITKYGV
110 120 130 140 150
KPHDIFEAND LFENTNHTQV QSTLLALASM AKTKGNKVNV GVKYAEKQER
160 170 180 190 200
KFEPGKLREG RNIIGLQMGT NKFASQQGMT AYGTRRHLYD PKLGTDQPLD
210 220 230 240 250
QATISLQMGT NKGASQAGMT APGTKRQIFE PGLGMEHCDT LNVSLQMGSN
260 270 280 290
KGASQRGMTV YGLPRQVYDP KYCLTPEYPE LGEPAHNHHA HNYYNSA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EU794601 mRNA Translation: ACJ13655.1 |
RefSeqi | NP_001290.2, NM_001299.5 |
Genome annotation databases
GeneIDi | 1264 |
KEGGi | hsa:1264 |
UCSCi | uc002msc.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EU794601 mRNA Translation: ACJ13655.1 |
RefSeqi | NP_001290.2, NM_001299.5 |
3D structure databases
SMRi | V9HWA5 |
ModBasei | Search... |
Proteomic databases
MaxQBi | V9HWA5 |
Protocols and materials databases
Antibodypediai | 1965, 1051 antibodies |
Genome annotation databases
GeneIDi | 1264 |
KEGGi | hsa:1264 |
UCSCi | uc002msc.2, human |
Organism-specific databases
CTDi | 1264 |
EuPathDBi | HostDB:ENSG00000130176.7 |
Phylogenomic databases
OMAi | GEPTHNH |
OrthoDBi | 861989at2759 |
PhylomeDBi | V9HWA5 |
Miscellaneous databases
BioGRID-ORCSi | 1264, 5 hits in 845 CRISPR screens |
ChiTaRSi | CNN1, human |
GenomeRNAii | 1264 |
Gene expression databases
Bgeei | ENSG00000130176, Expressed in lower esophagus muscularis layer and 193 other tissues |
ExpressionAtlasi | V9HWA5, baseline and differential |
Family and domain databases
CDDi | cd00014, CH, 1 hit |
Gene3Di | 1.10.418.10, 1 hit |
InterProi | View protein in InterPro IPR001997, Calponin/LIMCH1 IPR000557, Calponin_repeat IPR001715, CH-domain IPR036872, CH_dom_sf IPR003096, SM22_calponin |
Pfami | View protein in Pfam PF00402, Calponin, 3 hits PF00307, CH, 1 hit |
PRINTSi | PR00889, CALPONIN PR00888, SM22CALPONIN |
SMARTi | View protein in SMART SM00033, CH, 1 hit |
SUPFAMi | SSF47576, SSF47576, 1 hit |
PROSITEi | View protein in PROSITE PS01052, CALPONIN_1, 2 hits PS51122, CALPONIN_2, 3 hits PS50021, CH, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | V9HWA5_HUMAN | |
Accessioni | V9HWA5Primary (citable) accession number: V9HWA5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 19, 2014 |
Last sequence update: | March 19, 2014 | |
Last modified: | December 2, 2020 | |
This is version 42 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |