UniProtKB - V9HW80 (V9HW80_HUMAN)
Protein
15S Mg(2+)-ATPase p97 subunit
Gene
HEL-S-70
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
- EC:3.6.4.6ARBA annotation
GO - Molecular functioni
- ADP binding Source: Ensembl
- ATPase activity Source: Ensembl
- ATP binding Source: UniProtKB-KW
- identical protein binding Source: Ensembl
- K48-linked polyubiquitin modification-dependent protein binding Source: Ensembl
- lipid binding Source: UniProtKB-KW
- MHC class I protein binding Source: Ensembl
- protein-containing complex binding Source: Ensembl
- ubiquitin-specific protease binding Source: Ensembl
GO - Biological processi
- activation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
- aggresome assembly Source: Ensembl
- ATP metabolic process Source: Ensembl
- autophagy Source: UniProtKB-KW
- endoplasmic reticulum to Golgi vesicle-mediated transport Source: Ensembl
- positive regulation of mitochondrial membrane potential Source: Ensembl
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: Ensembl
- proteasome-mediated ubiquitin-dependent protein catabolic process Source: Ensembl
- regulation of synapse organization Source: Ensembl
- retrograde protein transport, ER to cytosol Source: Ensembl
Keywordsi
Biological process | AutophagyARBA annotation |
Ligand | ATP-bindingARBA annotation, Lipid-bindingARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: 15S Mg(2+)-ATPase p97 subunitARBA annotation (EC:3.6.4.6ARBA annotation)Alternative name(s): Transitional endoplasmic reticulum ATPaseARBA annotation Valosin-containing proteinARBA annotation |
Gene namesi | Name:HEL-S-70Imported Synonyms:HEL-220Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000165280.15 |
Subcellular locationi
Other locations
- Stress granule ARBA annotation
Cytosol
- cytosol Source: HPA
Endoplasmic reticulum
- Derlin-1 retrotranslocation complex Source: Ensembl
- VCP-NPL4-UFD1 AAA ATPase complex Source: Ensembl
Nucleus
- nucleoplasm Source: HPA
Other locations
- ATPase complex Source: Ensembl
- cytoplasmic stress granule Source: UniProtKB-SubCell
- glutamatergic synapse Source: Ensembl
- VCP-NSFL1C complex Source: Ensembl
Expressioni
Gene expression databases
Bgeei | ENSG00000165280, Expressed in stromal cell of endometrium and 242 other tissues |
ExpressionAtlasi | V9HW80, baseline and differential |
Interactioni
Binary interactionsi
Hide detailsV9HW80
GO - Molecular functioni
- identical protein binding Source: Ensembl
- K48-linked polyubiquitin modification-dependent protein binding Source: Ensembl
- MHC class I protein binding Source: Ensembl
- ubiquitin-specific protease binding Source: Ensembl
Protein-protein interaction databases
IntActi | V9HW80, 16 interactors |
Chemistry databases
BindingDBi | V9HW80 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 25 – 108 | CDC48_NInterPro annotationAdd BLAST | 84 | |
Domaini | 125 – 191 | CDC48_2InterPro annotationAdd BLAST | 67 | |
Domaini | 237 – 373 | AAAInterPro annotationAdd BLAST | 137 | |
Domaini | 510 – 649 | AAAInterPro annotationAdd BLAST | 140 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 708 – 727 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 768 – 806 | DisorderedSequence analysisAdd BLAST | 39 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 768 – 794 | PolarSequence analysisAdd BLAST | 27 |
Sequence similaritiesi
Belongs to the AAA ATPase family.ARBA annotation
Phylogenomic databases
HOGENOMi | CLU_000688_12_3_1 |
OMAi | PIDDTTE |
OrthoDBi | 194195at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR005938, AAA_ATPase_CDC48 IPR041569, AAA_lid_3 IPR009010, Asp_de-COase-like_dom_sf IPR003959, ATPase_AAA_core IPR003960, ATPase_AAA_CS IPR004201, Cdc48_dom2 IPR029067, CDC48_domain_2-like_sf IPR003338, CDC4_N-term_subdom IPR027417, P-loop_NTPase IPR015415, Vps4_C |
Pfami | View protein in Pfam PF00004, AAA, 2 hits PF17862, AAA_lid_3, 2 hits PF02933, CDC48_2, 1 hit PF02359, CDC48_N, 1 hit PF09336, Vps4_C, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 2 hits SM01072, CDC48_2, 1 hit SM01073, CDC48_N, 1 hit |
SUPFAMi | SSF50692, SSF50692, 1 hit SSF52540, SSF52540, 2 hits SSF54585, SSF54585, 1 hit |
TIGRFAMsi | TIGR01243, CDC48, 1 hit |
PROSITEi | View protein in PROSITE PS00674, AAA, 2 hits |
i Sequence
Sequence statusi: Complete.
V9HW80-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASGADSKGD DLSTAILKQK NRPNRLIVDE AINEDNSVVS LSQPKMDELQ
60 70 80 90 100
LFRGDTVLLK GKKRREAVCI VLSDDTCSDE KIRMNRVVRN NLRVRLGDVI
110 120 130 140 150
SIQPCPDVKY GKRIHVLPID DTVEGITGNL FEVYLKPYFL EAYRPIRKGD
160 170 180 190 200
IFLVRGGMRA VEFKVVETDP SPYCIVAPDT VIHCEGEPIK REDEEESLNE
210 220 230 240 250
VGYDDIGGCR KQLAQIKEMV ELPLRHPALF KAIGVKPPRG ILLYGPPGTG
260 270 280 290 300
KTLIARAVAN ETGAFFFLIN GPEIMSKLAG ESESNLRKAF EEAEKNAPAI
310 320 330 340 350
IFIDELDAIA PKREKTHGEV ERRIVSQLLT LMDGLKQRAH VIVMAATNRP
360 370 380 390 400
NSIDPALRRF GRFDREVDIG IPDATGRLEI LQIHTKNMKL ADDVDLEQVA
410 420 430 440 450
NETHGHVGAD LAALCSEAAL QAIRKKMDLI DLEDETIDAE VMNSLAVTMD
460 470 480 490 500
DFRWALSQSN PSALRETVVE VPQVTWEDIG GLEDVKRELQ ELVQYPVEHP
510 520 530 540 550
DKFLKFGMTP SKGVLFYGPP GCGKTLLAKA IANECQANFI SIKGPELLTM
560 570 580 590 600
WFGESEANVR EIFDKARQAA PCVLFFDELD SIAKARGGNI GDGGGAADRV
610 620 630 640 650
INQILTEMDG MSTKKNVFII GATNRPDIID PAILRPGRLD QLIYIPLPDE
660 670 680 690 700
KSRVAILKAN LRKSPVAKDV DLEFLAKMTN GFSGADLTEI CQRACKLAIR
710 720 730 740 750
ESIESEIRRE RERQTNPSAM EVEEDDPVPE IRRDHFEEAM RFARRSVSDN
760 770 780 790 800
DIRKYEMFAQ TLQQSRGFGS FRFPSGNQGG AGPSQGSGGG TGGSVYTEDN
DDDLYG
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | FJ224344 mRNA Translation: ACI46036.1 FJ224352 mRNA Translation: ACI46044.1 |
RefSeqi | NP_009057.1, NM_007126.3 |
Genome annotation databases
GeneIDi | 7415 |
KEGGi | hsa:7415 |
UCSCi | uc003zvy.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | FJ224344 mRNA Translation: ACI46036.1 FJ224352 mRNA Translation: ACI46044.1 |
RefSeqi | NP_009057.1, NM_007126.3 |
3D structure databases
SMRi | V9HW80 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | V9HW80, 16 interactors |
Chemistry databases
BindingDBi | V9HW80 |
Proteomic databases
MaxQBi | V9HW80 |
PRIDEi | V9HW80 |
Protocols and materials databases
Antibodypediai | 2215, 647 antibodies |
DNASUi | 7415 |
Genome annotation databases
GeneIDi | 7415 |
KEGGi | hsa:7415 |
UCSCi | uc003zvy.3, human |
Organism-specific databases
CTDi | 7415 |
VEuPathDBi | HostDB:ENSG00000165280.15 |
Phylogenomic databases
HOGENOMi | CLU_000688_12_3_1 |
OMAi | PIDDTTE |
OrthoDBi | 194195at2759 |
Miscellaneous databases
BioGRID-ORCSi | 7415, 799 hits in 966 CRISPR screens |
ChiTaRSi | VCP, human |
GenomeRNAii | 7415 |
Gene expression databases
Bgeei | ENSG00000165280, Expressed in stromal cell of endometrium and 242 other tissues |
ExpressionAtlasi | V9HW80, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR005938, AAA_ATPase_CDC48 IPR041569, AAA_lid_3 IPR009010, Asp_de-COase-like_dom_sf IPR003959, ATPase_AAA_core IPR003960, ATPase_AAA_CS IPR004201, Cdc48_dom2 IPR029067, CDC48_domain_2-like_sf IPR003338, CDC4_N-term_subdom IPR027417, P-loop_NTPase IPR015415, Vps4_C |
Pfami | View protein in Pfam PF00004, AAA, 2 hits PF17862, AAA_lid_3, 2 hits PF02933, CDC48_2, 1 hit PF02359, CDC48_N, 1 hit PF09336, Vps4_C, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 2 hits SM01072, CDC48_2, 1 hit SM01073, CDC48_N, 1 hit |
SUPFAMi | SSF50692, SSF50692, 1 hit SSF52540, SSF52540, 2 hits SSF54585, SSF54585, 1 hit |
TIGRFAMsi | TIGR01243, CDC48, 1 hit |
PROSITEi | View protein in PROSITE PS00674, AAA, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | V9HW80_HUMAN | |
Accessioni | V9HW80Primary (citable) accession number: V9HW80 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 19, 2014 |
Last sequence update: | March 19, 2014 | |
Last modified: | April 7, 2021 | |
This is version 69 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |