UniProtKB - V9HW43 (V9HW43_HUMAN)
Protein
Heat shock 27 kDa protein
Gene
HEL-S-102
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- protein kinase C binding Source: Ensembl
- protein kinase C inhibitor activity Source: Ensembl
GO - Biological processi
- negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway Source: Ensembl
- positive regulation of interleukin-1 beta production Source: Ensembl
- positive regulation of tumor necrosis factor biosynthetic process Source: Ensembl
- regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
Names & Taxonomyi
Protein namesi | Recommended name: Heat shock 27 kDa proteinARBA annotationAlternative name(s): Heat shock protein beta-1ARBA annotation |
Gene namesi | Name:HEL-S-102Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000106211.8 |
Subcellular locationi
Cytoskeleton
- spindle Source: UniProtKB-SubCell
Nucleus
- nucleus Source: UniProtKB-SubCell
Plasma Membrane
- plasma membrane Source: Ensembl
Other locations
- Z disc Source: Ensembl
Keywords - Cellular componenti
Cytoplasm, CytoskeletonARBA annotation, NucleusARBA annotationExpressioni
Gene expression databases
Bgeei | ENSG00000106211, Expressed in myometrium and 241 other tissues |
ExpressionAtlasi | V9HW43, baseline and differential |
Interactioni
GO - Molecular functioni
- protein kinase C binding Source: Ensembl
Protein-protein interaction databases
IntActi | V9HW43, 1 interactor |
Chemistry databases
BindingDBi | V9HW43 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 76 – 184 | SHSPInterPro annotationAdd BLAST | 109 |
Sequence similaritiesi
Belongs to the small heat shock protein (HSP20) family.PROSITE-ProRule annotation
Phylogenomic databases
HOGENOMi | CLU_095001_0_0_1 |
OMAi | EEWAQWF |
OrthoDBi | 1187096at2759 |
PhylomeDBi | V9HW43 |
Family and domain databases
CDDi | cd06475, ACD_HspB1_like, 1 hit |
Gene3Di | 2.60.40.790, 1 hit |
InterProi | View protein in InterPro IPR002068, A-crystallin/Hsp20_dom IPR037876, ACD_HspB1 IPR001436, Alpha-crystallin/sHSP_animal IPR008978, HSP20-like_chaperone |
PANTHERi | PTHR45640, PTHR45640, 1 hit |
Pfami | View protein in Pfam PF00011, HSP20, 1 hit |
PRINTSi | PR00299, ACRYSTALLIN |
SUPFAMi | SSF49764, SSF49764, 1 hit |
PROSITEi | View protein in PROSITE PS01031, SHSP, 1 hit |
i Sequence
Sequence statusi: Complete.
V9HW43-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTERRVPFSL LRGPSWDPFR DWYPHSRLFD QAFGLPRLPE EWSQWLGGSS
60 70 80 90 100
WPGYVRPLPP AAIESPAVAA PAYSRALSRQ LSSGVSEIRH TADRWRVSLD
110 120 130 140 150
VNHFAPDELT VKTKDGVVEI TGKHEERQDE HGYISRCFTR KYTLPPGVDP
160 170 180 190 200
TQVSSSLSPE GTLTVEAPMP KLATQSNEIT IPVTFESRAQ LGGPEAAKSD
ETAAK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | FJ224323 mRNA Translation: ACI46015.1 |
RefSeqi | NP_001531.1, NM_001540.3 |
Genome annotation databases
GeneIDi | 3315 |
KEGGi | hsa:3315 |
UCSCi | uc003uew.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | FJ224323 mRNA Translation: ACI46015.1 |
RefSeqi | NP_001531.1, NM_001540.3 |
3D structure databases
SMRi | V9HW43 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | V9HW43, 1 interactor |
Chemistry databases
BindingDBi | V9HW43 |
Proteomic databases
MaxQBi | V9HW43 |
PRIDEi | V9HW43 |
Protocols and materials databases
Antibodypediai | 603, 3038 antibodies |
Genome annotation databases
GeneIDi | 3315 |
KEGGi | hsa:3315 |
UCSCi | uc003uew.4, human |
Organism-specific databases
CTDi | 3315 |
EuPathDBi | HostDB:ENSG00000106211.8 |
Phylogenomic databases
HOGENOMi | CLU_095001_0_0_1 |
OMAi | EEWAQWF |
OrthoDBi | 1187096at2759 |
PhylomeDBi | V9HW43 |
Miscellaneous databases
BioGRID-ORCSi | 3315, 6 hits in 845 CRISPR screens |
ChiTaRSi | HSPB1, human |
GenomeRNAii | 3315 |
Gene expression databases
Bgeei | ENSG00000106211, Expressed in myometrium and 241 other tissues |
ExpressionAtlasi | V9HW43, baseline and differential |
Family and domain databases
CDDi | cd06475, ACD_HspB1_like, 1 hit |
Gene3Di | 2.60.40.790, 1 hit |
InterProi | View protein in InterPro IPR002068, A-crystallin/Hsp20_dom IPR037876, ACD_HspB1 IPR001436, Alpha-crystallin/sHSP_animal IPR008978, HSP20-like_chaperone |
PANTHERi | PTHR45640, PTHR45640, 1 hit |
Pfami | View protein in Pfam PF00011, HSP20, 1 hit |
PRINTSi | PR00299, ACRYSTALLIN |
SUPFAMi | SSF49764, SSF49764, 1 hit |
PROSITEi | View protein in PROSITE PS01031, SHSP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | V9HW43_HUMAN | |
Accessioni | V9HW43Primary (citable) accession number: V9HW43 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 19, 2014 |
Last sequence update: | March 19, 2014 | |
Last modified: | December 2, 2020 | |
This is version 50 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |