HEL-S-102

Functionⁱ

GO - Molecular functionⁱ

protein kinase C binding Source: Ensembl
protein kinase C inhibitor activity Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway Source: Ensembl
positive regulation of interleukin-1 beta production Source: Ensembl
positive regulation of tumor necrosis factor biosynthetic process Source: Ensembl
regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Epididymis secretory protein Li 102Imported
Gene namesⁱ	Name:HEL-S-102Imported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000106211.8

EuPathDBⁱ

HostDB:ENSG00000106211.8

Subcellular locationⁱ

GO - Cellular component

PTM / Processingⁱ

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	V9HW43
PRIDEⁱ	V9HW43

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000106211 Expressed in 230 organ(s), highest expression level in myometrium
ExpressionAtlasⁱ	V9HW43 baseline and differential

Interactionⁱ

GO - Molecular functionⁱ

protein kinase C binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	V9HW43
SMRⁱ	V9HW43
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	76 – 184	SHSPInterPro annotationAdd BLAST		109

Sequence similaritiesⁱ

Belongs to the small heat shock protein (HSP20) family.PROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGⁱ	KOG3591 Eukaryota ENOG410YERS LUCA
KEGG Orthology (KO) More...KOⁱ	K04455
OMAⁱ	FDQSFGM
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0USC
PhylomeDBⁱ	V9HW43

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd06475 ACD_HspB1_like, 1 hit
Gene3Dⁱ	2.60.40.790, 1 hit
InterProⁱ	View protein in InterPro IPR002068 A-crystallin/Hsp20_dom IPR037876 ACD_HspB1 IPR001436 Alpha-crystallin/HSP IPR031107 HSP20 IPR008978 HSP20-like_chaperone
PANTHERⁱ	PTHR11527 PTHR11527, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00011 HSP20, 1 hit
PRINTSⁱ	PR00299 ACRYSTALLIN
SUPFAMⁱ	SSF49764 SSF49764, 1 hit
PROSITEⁱ	View protein in PROSITE PS01031 SHSP, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

V9HW43-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MTERRVPFSL LRGPSWDPFR DWYPHSRLFD QAFGLPRLPE EWSQWLGGSS 
        60         70         80         90        100
WPGYVRPLPP AAIESPAVAA PAYSRALSRQ LSSGVSEIRH TADRWRVSLD 
       110        120        130        140        150
VNHFAPDELT VKTKDGVVEI TGKHEERQDE HGYISRCFTR KYTLPPGVDP 
       160        170        180        190        200
TQVSSSLSPE GTLTVEAPMP KLATQSNEIT IPVTFESRAQ LGGPEAAKSD 

ETAAK

Length:205

Mass (Da):22,783

Last modified:March 19, 2014 - v1

Checksum:ⁱ1B4DC44A6F6606D5

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	FJ224323 mRNA Translation: ACI46015.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001531.1, NM_001540.3
UniGeneⁱ	Hs.520973

Genome annotation databases

GeneIDⁱ	3315
KEGGⁱ	hsa:3315
UCSC genome browser More...UCSCⁱ	uc003uew.4 human

Protein	Similar proteins		Species	Score	Length	Source
V9HW43	Heat shock protein beta-1	)	HUMAN		205	UniRef100_P04792
Heat shock protein beta-1		MACMU		205
HSPB1 isoform 1		PANTR		205
Uncharacterized protein		PANPA		205
Heat shock protein family B (small) member 1		GORGO		205
+7

Protein	Similar proteins		Species	Score	Length	Source
V9HW43	Heat shock protein beta-1	)	HUMAN		205	UniRef90_P04792
Heat shock protein beta-1		MACMU		205
HSPB1 isoform 1		PANTR		205
Uncharacterized protein		PANPA		205
Heat shock protein family B (small) member 1		GORGO		205
+17

Protein	Similar proteins		Species	Score	Length	Source
V9HW43	Heat shock protein beta-1	)	HUMAN		205	UniRef50_P04792
Heat shock protein beta-1		MOUSE		209
Heat shock protein beta-1		CANLF		209
Heat shock protein beta-1		MACMU		205
HSPB1 isoform 1		PANTR		205
+51

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	FJ224323 mRNA Translation: ACI46015.1
RefSeqⁱ	NP_001531.1, NM_001540.3
UniGeneⁱ	Hs.520973

3D structure databases

ProteinModelPortalⁱ	V9HW43
SMRⁱ	V9HW43
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

MaxQBⁱ	V9HW43
PRIDEⁱ	V9HW43

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	3315
KEGGⁱ	hsa:3315
UCSCⁱ	uc003uew.4 human

Organism-specific databases

CTDⁱ	3315
EuPathDBⁱ	HostDB:ENSG00000106211.8

Phylogenomic databases

eggNOGⁱ	KOG3591 Eukaryota ENOG410YERS LUCA
KOⁱ	K04455
OMAⁱ	FDQSFGM
OrthoDBⁱ	EOG091G0USC
PhylomeDBⁱ	V9HW43

Miscellaneous databases

ChiTaRSⁱ	HSPB1 human
GenomeRNAiⁱ	3315

Gene expression databases

Bgeeⁱ	ENSG00000106211 Expressed in 230 organ(s), highest expression level in myometrium
ExpressionAtlasⁱ	V9HW43 baseline and differential

Family and domain databases

CDDⁱ	cd06475 ACD_HspB1_like, 1 hit
Gene3Dⁱ	2.60.40.790, 1 hit
InterProⁱ	View protein in InterPro IPR002068 A-crystallin/Hsp20_dom IPR037876 ACD_HspB1 IPR001436 Alpha-crystallin/HSP IPR031107 HSP20 IPR008978 HSP20-like_chaperone
PANTHERⁱ	PTHR11527 PTHR11527, 1 hit
Pfamⁱ	View protein in Pfam PF00011 HSP20, 1 hit
PRINTSⁱ	PR00299 ACRYSTALLIN
SUPFAMⁱ	SSF49764 SSF49764, 1 hit
PROSITEⁱ	View protein in PROSITE PS01031 SHSP, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	V9HW43_HUMAN
Accessionⁱ	V9HW43Primary (citable) accession number: V9HW43
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	March 19, 2014
	Last sequence update:	March 19, 2014
	Last modified:	September 12, 2018
	This is version 40 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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UniProtKB - V9HW43 (V9HW43_HUMAN)

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Epididymis secretory protein Li 102

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Plasma Membrane

Other locations

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ