UniProtKB - V9HVY3 (V9HVY3_HUMAN)
Protein
Protein disulfide-isomerase
Gene
HEL-S-269
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
GO - Molecular functioni
- protein disulfide isomerase activity Source: UniProtKB-EC
GO - Biological processi
- cellular response to interleukin-7 Source: Ensembl
- positive regulation of extrinsic apoptotic signaling pathway Source: Ensembl
Keywordsi
Molecular function | IsomeraseUniRule annotationImportedARBA annotation |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:HEL-S-269Imported Synonyms:HEL-S-93nImported, PDIA3Imported ORF Names:hCG_38001Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000167004.12 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum lumen ARBA annotation
Other locations
- Melanosome ARBA annotation
Endoplasmic reticulum
- endoplasmic reticulum Source: HPA
- endoplasmic reticulum lumen Source: UniProtKB-SubCell
Other locations
- cell surface Source: Ensembl
- melanosome Source: UniProtKB-SubCell
Keywords - Cellular componenti
Endoplasmic reticulumARBA annotationPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 24 | UniRule annotationAdd BLAST | 24 | |
ChainiPRO_5014206131 | 25 – 505 | Protein disulfide-isomeraseUniRule annotationAdd BLAST | 481 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 57 ↔ 60 | Redox-activeUniRule annotation | ||
Disulfide bondi | 406 ↔ 409 | Redox-activeUniRule annotation |
Keywords - PTMi
Disulfide bondUniRule annotationProteomic databases
MaxQBi | V9HVY3 |
Expressioni
Gene expression databases
Bgeei | ENSG00000167004, Expressed in corpus epididymis and 240 other tissues |
ExpressionAtlasi | V9HVY3, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 19 – 133 | ThioredoxinInterPro annotationAdd BLAST | 115 | |
Domaini | 343 – 485 | ThioredoxinInterPro annotationAdd BLAST | 143 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 484 – 505 | DisorderedSequence analysisAdd BLAST | 22 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 489 – 505 | PolyampholyteSequence analysisAdd BLAST | 17 |
Sequence similaritiesi
Keywords - Domaini
Redox-active centerUniRule annotationARBA annotation, RepeatARBA annotation, SignalUniRule annotationARBA annotationPhylogenomic databases
HOGENOMi | CLU_025879_6_0_1 |
OMAi | VAIVKMD |
OrthoDBi | 462118at2759 |
Family and domain databases
CDDi | cd03069, PDI_b_ERp57, 1 hit |
Gene3Di | 3.40.30.10, 4 hits |
InterProi | View protein in InterPro IPR005788, Disulphide_isomerase IPR041868, PDIA3_PDI_b IPR005792, Prot_disulphide_isomerase IPR036249, Thioredoxin-like_sf IPR017937, Thioredoxin_CS IPR013766, Thioredoxin_domain |
Pfami | View protein in Pfam PF00085, Thioredoxin, 2 hits |
SUPFAMi | SSF52833, SSF52833, 4 hits |
TIGRFAMsi | TIGR01130, ER_PDI_fam, 1 hit TIGR01126, pdi_dom, 2 hits |
PROSITEi | View protein in PROSITE PS00194, THIOREDOXIN_1, 2 hits PS51352, THIOREDOXIN_2, 2 hits |
i Sequence
Sequence statusi: Complete.
V9HVY3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRLRRLALFP GVALLLAAAR LAAASDVLEL TDDNFESRIS DTGSAGLMLV
60 70 80 90 100
EFFAPWCGHC KRLAPEYEAA ATRLKGIVPL AKVDCTANTN TCNKYGVSGY
110 120 130 140 150
PTLKIFRDGE EAGAYDGPRT ADGIVSHLKK QAGPASVPLR TEEEFKKFIS
160 170 180 190 200
DKDASIVGFF DDSFSEAHSE FLKAASNLRD NYRFAHTNVE SLVNEYDDNG
210 220 230 240 250
EGIILFRPSH LTNKFEDKTV AYTEQKMTSG KIKKFIQENI FGICPHMTED
260 270 280 290 300
NKDLIQGKDL LIAYYDVDYE KNAKGSNYWR NRVMMVAKKF LDAGHKLNFA
310 320 330 340 350
VASRKTFSHE LSDFGLESTA GEIPVVAIRT AKGEKFVMQE EFSRDGKALE
360 370 380 390 400
RFLQDYFDGN LKRYLKSEPI PESNDGPVKV VVAENFDEIV NNENKDVLIE
410 420 430 440 450
FYAPWCGHCK NLEPKYKELG EKLSKDPNIV IAKMDATAND VPSPYEVRGF
460 470 480 490 500
PTIYFSPANK KLNPKKYEGG RELSDFISYL QREATNPPVI QEEKPKKKKK
AQEDL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EU668338 mRNA Translation: ACF94491.1 FJ224330 mRNA Translation: ACI46022.1 CH471082 Genomic DNA Translation: EAW77236.1 |
RefSeqi | NP_005304.3, NM_005313.4 |
Genome annotation databases
GeneIDi | 2923 |
KEGGi | hsa:2923 |
UCSCi | uc001zsu.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EU668338 mRNA Translation: ACF94491.1 FJ224330 mRNA Translation: ACI46022.1 CH471082 Genomic DNA Translation: EAW77236.1 |
RefSeqi | NP_005304.3, NM_005313.4 |
3D structure databases
SMRi | V9HVY3 |
ModBasei | Search... |
Proteomic databases
MaxQBi | V9HVY3 |
Protocols and materials databases
Antibodypediai | 1223, 893 antibodies |
Genome annotation databases
GeneIDi | 2923 |
KEGGi | hsa:2923 |
UCSCi | uc001zsu.4, human |
Organism-specific databases
CTDi | 2923 |
EuPathDBi | HostDB:ENSG00000167004.12 |
Phylogenomic databases
HOGENOMi | CLU_025879_6_0_1 |
OMAi | VAIVKMD |
OrthoDBi | 462118at2759 |
Miscellaneous databases
BioGRID-ORCSi | 2923, 16 hits in 840 CRISPR screens |
ChiTaRSi | PDIA3, human |
GenomeRNAii | 2923 |
Gene expression databases
Bgeei | ENSG00000167004, Expressed in corpus epididymis and 240 other tissues |
ExpressionAtlasi | V9HVY3, baseline and differential |
Family and domain databases
CDDi | cd03069, PDI_b_ERp57, 1 hit |
Gene3Di | 3.40.30.10, 4 hits |
InterProi | View protein in InterPro IPR005788, Disulphide_isomerase IPR041868, PDIA3_PDI_b IPR005792, Prot_disulphide_isomerase IPR036249, Thioredoxin-like_sf IPR017937, Thioredoxin_CS IPR013766, Thioredoxin_domain |
Pfami | View protein in Pfam PF00085, Thioredoxin, 2 hits |
SUPFAMi | SSF52833, SSF52833, 4 hits |
TIGRFAMsi | TIGR01130, ER_PDI_fam, 1 hit TIGR01126, pdi_dom, 2 hits |
PROSITEi | View protein in PROSITE PS00194, THIOREDOXIN_1, 2 hits PS51352, THIOREDOXIN_2, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | V9HVY3_HUMAN | |
Accessioni | V9HVY3Primary (citable) accession number: V9HVY3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 19, 2014 |
Last sequence update: | March 19, 2014 | |
Last modified: | December 2, 2020 | |
This is version 69 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |