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Entry version 31 (07 Apr 2021)
Sequence version 1 (19 Feb 2014)
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Protein

C4a anaphylatoxin

Gene
N/A
Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processComplement pathwayARBA annotation, Immunity, Inflammatory responseARBA annotation, Innate immunity

Protein family/group databases

MEROPS protease database

More...
MEROPSi
I39.951

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
C4a anaphylatoxinARBA annotation
Alternative name(s):
Complement C4 gamma chainARBA annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell junction, Cell projectionARBA annotation, SecretedARBA annotation, SynapseARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

Cleavage on pair of basic residuesARBA annotation, Disulfide bondARBA annotation, GlycoproteinARBA annotation, SulfationARBA annotation, Thioester bondARBA annotation

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
V9GZG9

PRoteomics IDEntifications database

More...
PRIDEi
V9GZG9

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini681 – 715Anaphylatoxin-likeInterPro annotationAdd BLAST35
Domaini1567 – 1714NTRInterPro annotationAdd BLAST148

Keywords - Domaini

SignalARBA annotation

Phylogenomic databases

Identification of Orthologs from Complete Genome Data

More...
OMAi
TAYFKDE

Database of Orthologous Groups

More...
OrthoDBi
28894at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00017, ANATO, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.50.120, 1 hit
2.60.40.10, 2 hits
2.60.40.690, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009048, A-macroglobulin_rcpt-bd
IPR036595, A-macroglobulin_rcpt-bd_sf
IPR011625, A2M_N_BRD
IPR011626, Alpha-macroglobulin_TED
IPR000020, Anaphylatoxin/fibulin
IPR018081, Anaphylatoxin_comp_syst
IPR001840, Anaphylatoxn_comp_syst_dom
IPR037569, Complement_C4A
IPR013783, Ig-like_fold
IPR001599, Macroglobln_a2
IPR019742, MacrogloblnA2_CS
IPR002890, MG2
IPR041555, MG3
IPR001134, Netrin_domain
IPR018933, Netrin_module_non-TIMP
IPR008930, Terpenoid_cyclase/PrenylTrfase
IPR008993, TIMP-like_OB-fold

The PANTHER Classification System

More...
PANTHERi
PTHR11412:SF86, PTHR11412:SF86, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00207, A2M, 1 hit
PF07703, A2M_BRD, 1 hit
PF07677, A2M_recep, 1 hit
PF01821, ANATO, 1 hit
PF01835, MG2, 1 hit
PF17791, MG3, 1 hit
PF01759, NTR, 1 hit
PF07678, TED_complement, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00004, ANAPHYLATOXN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01360, A2M, 1 hit
SM01359, A2M_N_2, 1 hit
SM01361, A2M_recep, 1 hit
SM00104, ANATO, 1 hit
SM00643, C345C, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47686, SSF47686, 1 hit
SSF48239, SSF48239, 1 hit
SSF49410, SSF49410, 1 hit
SSF50242, SSF50242, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00477, ALPHA_2_MACROGLOBULIN, 1 hit
PS01177, ANAPHYLATOXIN_1, 1 hit
PS01178, ANAPHYLATOXIN_2, 1 hit
PS50189, NTR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

V9GZG9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
KPRLLLFSPS VVNLGTPLSV GVQLLDAPPG QEVKGSVFLR NPKGGSCSPK
60 70 80 90 100
KDFKLSLGDD FVLLSLEVPL EDVRSCGLFD LRRAPYIQLV AQSPWLRNTA
110 120 130 140 150
FKATETQGVN LLYSSRRGHI FVQTDQPIYN PGQRVRYRVF ALDQKMRPST
160 170 180 190 200
DFLTITVENS HGLRVLKKEI FTSTSIFQDA FTIPDISEPG TWKISARFSD
210 220 230 240 250
GLESNRSTHF EVKKYVLPNF EVKITPWKPY ILMVPSNSDE IQLDIQARYI
260 270 280 290 300
YGKPVQGVAY TRFALMDEQG KRTFLQGLET QAKLVEGRTH ISISKDQFQA
310 320 330 340 350
ALDKINIGVR DLEGLRLYAA TAVIESPGGE MEEAELTSWR FVSSAFSLDL
360 370 380 390 400
SRTTAQLVPG AHFLLQALVR EISGSEASNV IVKVSATLVS GSDSQVLNVQ
410 420 430 440 450
QSTNRIGQVS ISFPIPPTVT ELRLLVSAGS LYPTIARLTV QSPPSRGTGF
460 470 480 490 500
LSIEPLDPRS PRVGDTFILN LQAVGIPAPT FSHYYYMIIS RGQIMAMSRE
510 520 530 540 550
ARRTVTSVSV LVDHQLAPSF YFVAYFYHQG HPVANSLLIN IQPRDCEGKL
560 570 580 590 600
QLKVVGAKEY HNGDMMKLQI QTDSKALVAL GAVDTALYAV GGWSHKPLDM
610 620 630 640 650
SKVFEVIDSY NLGCGPGGGD DAPQVFQDAG LAFSDGDRLT QTREDLSCPK
660 670 680 690 700
EKKSRQKRNV NFLKALSEKL GQYSSPDAKR CCQDGMTKLP MKRTCEQRAA
710 720 730 740 750
RVPQQACREP FLSCCKFAED LRRNQTRSQA HLARKVRDMV NLIEEDDILV
760 770 780 790 800
RTSFPDNWLW RVEPVDSSKL LTVRLPDSMT TWEIHGVSLS KSKGLCVAKP
810 820 830 840 850
TRVRVFRKFH LHLRLPISVR RFEQLELRPV LYNYLNDDKN VSVHVTPVEG
860 870 880 890 900
LCMAGGGMMA QWVIVPAGSA LPVAFSVVPT ASTNVPLKLV AKGTLDSSDS
910 920 930 940 950
VSKILQIEKE GAIHREEIVY NLDPLNNLGQ MLEIPGSSDP NIVPEGDFST
960 970 980 990 1000
FVKVTASEPL ETLGSEGALS PGGVASLLRL PRSCAEQTMI YLAPTLTASN
1010 1020 1030 1040 1050
YLDRTKQWSK LSPETKDHAV HLIQKGHVRI QQFRKKDGSF GAWLHRDSST
1060 1070 1080 1090 1100
WLTAFVLKIL SLAQEQVGNS PEKLQETASW LLAQQLGDGS FHDPCPVIHR
1110 1120 1130 1140 1150
AMQGGLVGSN ETVALTAFVV IALHHGLNVF REGHAKQLKN RVEASITKAN
1160 1170 1180 1190 1200
SFLGQKASAG LLGAHAAAIT AYALTLTKAS EDLRNVAHNS LMAMAEETGE
1210 1220 1230 1240 1250
NLYWGLVLGS QDKVMLRPRD PRSPTEPVPQ APALWIETTA YALLHLLLRE
1260 1270 1280 1290 1300
GKGKMADKAA SWLTHQGNFH GAFRSTQDTV VTLDALSAYW IASHTTEEKA
1310 1320 1330 1340 1350
LNVTLSSMGR NGLKTHGLHL NNHQVKGLEE ELKFSLGSTI SVKVEGNSKG
1360 1370 1380 1390 1400
TLKILRTYNV LDMKNTTCQD LQIEVKVTDA VEYAWSAYED YEDDYNMPAT
1410 1420 1430 1440 1450
DDPSVPLQPV TPLELFEGRR SRRRREAPKV AEERESRVHY TVCIWRNGKL
1460 1470 1480 1490 1500
GLSGMAIADI TLLSGFHALR ADLEKLTSLS DRYVSHFETD GPHVLLYFDS
1510 1520 1530 1540 1550
VPTTRECVGF GASQEVVVGL VQPASAVLYD YYSPDHKCSV FYAAPTKSQL
1560 1570 1580 1590 1600
LATLCSGDVC QCAEGKCPRL LRSLERRVED KDGYRMRFAC YYHQVEYGFT
1610 1620 1630 1640 1650
VKVLREDGRA AFRLFESKIT QVLHFRTDTM ASIGQTRNFL SRASCRLRLE
1660 1670 1680 1690 1700
PNKEYLIMGM DGETSDNKGD PQYLLDSNTW IEEMPSEQMC KSTRHRAACF
1710
QLKDFLMEFS SRGCQV
Length:1,716
Mass (Da):190,707
Last modified:February 19, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDB986884F57023D8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M12384 mRNA Translation: AAA39683.1

NCBI Reference Sequences

More...
RefSeqi
NP_035543.2, NM_011413.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
625018

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:625018

UCSC genome browser

More...
UCSCi
uc008cdp.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M12384 mRNA Translation: AAA39683.1
RefSeqiNP_035543.2, NM_011413.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein family/group databases

MEROPSiI39.951

Proteomic databases

PeptideAtlasiV9GZG9
PRIDEiV9GZG9

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
625018

Genome annotation databases

GeneIDi625018
KEGGimmu:625018
UCSCiuc008cdp.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
720

Phylogenomic databases

OMAiTAYFKDE
OrthoDBi28894at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
625018, 0 hits in 7 CRISPR screens

Family and domain databases

CDDicd00017, ANATO, 1 hit
Gene3Di2.40.50.120, 1 hit
2.60.40.10, 2 hits
2.60.40.690, 1 hit
InterProiView protein in InterPro
IPR009048, A-macroglobulin_rcpt-bd
IPR036595, A-macroglobulin_rcpt-bd_sf
IPR011625, A2M_N_BRD
IPR011626, Alpha-macroglobulin_TED
IPR000020, Anaphylatoxin/fibulin
IPR018081, Anaphylatoxin_comp_syst
IPR001840, Anaphylatoxn_comp_syst_dom
IPR037569, Complement_C4A
IPR013783, Ig-like_fold
IPR001599, Macroglobln_a2
IPR019742, MacrogloblnA2_CS
IPR002890, MG2
IPR041555, MG3
IPR001134, Netrin_domain
IPR018933, Netrin_module_non-TIMP
IPR008930, Terpenoid_cyclase/PrenylTrfase
IPR008993, TIMP-like_OB-fold
PANTHERiPTHR11412:SF86, PTHR11412:SF86, 1 hit
PfamiView protein in Pfam
PF00207, A2M, 1 hit
PF07703, A2M_BRD, 1 hit
PF07677, A2M_recep, 1 hit
PF01821, ANATO, 1 hit
PF01835, MG2, 1 hit
PF17791, MG3, 1 hit
PF01759, NTR, 1 hit
PF07678, TED_complement, 1 hit
PRINTSiPR00004, ANAPHYLATOXN
SMARTiView protein in SMART
SM01360, A2M, 1 hit
SM01359, A2M_N_2, 1 hit
SM01361, A2M_recep, 1 hit
SM00104, ANATO, 1 hit
SM00643, C345C, 1 hit
SUPFAMiSSF47686, SSF47686, 1 hit
SSF48239, SSF48239, 1 hit
SSF49410, SSF49410, 1 hit
SSF50242, SSF50242, 1 hit
PROSITEiView protein in PROSITE
PS00477, ALPHA_2_MACROGLOBULIN, 1 hit
PS01177, ANAPHYLATOXIN_1, 1 hit
PS01178, ANAPHYLATOXIN_2, 1 hit
PS50189, NTR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiV9GZG9_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: V9GZG9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 19, 2014
Last sequence update: February 19, 2014
Last modified: April 7, 2021
This is version 31 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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