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Protein
Submitted name:

WD repeat-containing protein 5

Gene

WDR5

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Submitted name:
WD repeat-containing protein 5Imported
Gene namesi
Name:WDR5Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000196363.9
HGNCiHGNC:12757 WDR5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000196363

PTM / Processingi

Proteomic databases

PeptideAtlasiV9GZ59
PRIDEiV9GZ59

Expressioni

Gene expression databases

BgeeiENSG00000196363 Expressed in 192 organ(s), highest expression level in testis
ExpressionAtlasiV9GZ59 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliV9GZ59
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 96WD_REPEATS_REGIONInterPro annotationAdd BLAST56
Repeati41 – 82WDPROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

WD repeatPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0266 Eukaryota
ENOG410XP3K LUCA
GeneTreeiENSGT00810000125363

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
IPR037834 WDR5
PANTHERiPTHR22847:SF560 PTHR22847:SF560, 1 hit
PfamiView protein in Pfam
PF00400 WD40, 1 hit
SMARTiView protein in SMART
SM00320 WD40, 1 hit
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

V9GZ59-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATEEKKPET EAARAQPTPS SSATQSKPTP VKPNYALKFT LAGHTKAVSS
60 70 80 90
VKFSPNGEWL ASSSADKLIK IWGAYDGKFE KTISGHKLGI SDVAWS
Length:96
Mass (Da):10,280
Last modified:October 5, 2016 - v8
Checksum:i6FBB0607B23E0513
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P61964WDR5_HUMAN
WD repeat-containing protein 5
WDR5 BIG3
334Annotation score:
V9GYQ5V9GYQ5_HUMAN
WD repeat-containing protein 5
WDR5
56Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei96Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX649632 Genomic DNA No translation available.
KF458945 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000608739; ENSP00000477449; ENSG00000196363
UCSCiuc064wwz.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX649632 Genomic DNA No translation available.
KF458945 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliV9GZ59
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiV9GZ59
PRIDEiV9GZ59

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000608739; ENSP00000477449; ENSG00000196363
UCSCiuc064wwz.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000196363.9
HGNCiHGNC:12757 WDR5
OpenTargetsiENSG00000196363
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0266 Eukaryota
ENOG410XP3K LUCA
GeneTreeiENSGT00810000125363

Gene expression databases

BgeeiENSG00000196363 Expressed in 192 organ(s), highest expression level in testis
ExpressionAtlasiV9GZ59 baseline and differential

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
IPR037834 WDR5
PANTHERiPTHR22847:SF560 PTHR22847:SF560, 1 hit
PfamiView protein in Pfam
PF00400 WD40, 1 hit
SMARTiView protein in SMART
SM00320 WD40, 1 hit
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiV9GZ59_HUMAN
AccessioniPrimary (citable) accession number: V9GZ59
Entry historyiIntegrated into UniProtKB/TrEMBL: February 19, 2014
Last sequence update: October 5, 2016
Last modified: September 12, 2018
This is version 39 of the entry and version 8 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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