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Entry version 34 (05 Jun 2019)
Sequence version 1 (19 Feb 2014)
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Protein
Submitted name:

Prion-like-(Q/N-rich)-domain-bearing protein

Gene

pqn-22

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionPrionImported

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Prion-like-(Q/N-rich)-domain-bearing proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:pqn-22Imported
ORF Names:C46G7.4Imported, CELE_C46G7.4Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IV

Organism-specific databases

WormBase

More...
WormBasei
C46G7.4s ; CE49448 ; WBGene00004112 ; pqn-22

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Keywords - Cellular componenti

    Amyloid

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Proteomic databases

    PeptideAtlas

    More...
    PeptideAtlasi
    V6CLV2

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    WBGene00004112 Expressed in 4 organ(s), highest expression level in multi-cellular organism

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    V6CLV2 baseline and differential

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    V6CLV2

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini88 – 113ZMInterPro annotationAdd BLAST26

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni163 – 218DisorderedSequence analysisAdd BLAST56
    Regioni414 – 434DisorderedSequence analysisAdd BLAST21
    Regioni469 – 561DisorderedSequence analysisAdd BLAST93
    Regioni585 – 700DisorderedSequence analysisAdd BLAST116
    Regioni724 – 766DisorderedSequence analysisAdd BLAST43
    Regioni778 – 984DisorderedSequence analysisAdd BLAST207

    Compositional bias

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi173 – 188PolyampholyteSequence analysisAdd BLAST16
    Compositional biasi493 – 561PolarSequence analysisAdd BLAST69
    Compositional biasi594 – 690PolarSequence analysisAdd BLAST97
    Compositional biasi724 – 754PolyampholyteSequence analysisAdd BLAST31
    Compositional biasi778 – 843PolarSequence analysisAdd BLAST66
    Compositional biasi863 – 943PolarSequence analysisAdd BLAST81

    Phylogenomic databases

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000174270

    Database of Orthologous Groups

    More...
    OrthoDBi
    211015at2759

    Family and domain databases

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR006643 Zasp-like_motif

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00735 ZM, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry has 1 described isoform and 19 potential isoforms that are computationally mapped.Show allAlign All

    V6CLV2-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MTEVCGVNVP PAIAPLFSLP QSSIDDIQNT SLNSIRSSHP FSYTKPTPGG
    60 70 80 90 100
    PKLHNRIKCP RVVPRSFWLS FEEDEELDVP LLEPEMPQTV HLQYNSPMGL
    110 120 130 140 150
    YSKEAAVEQF QQQIGETPND LPAQEKHFDP SKSATLKYLK EGERENFGEN
    160 170 180 190 200
    FFEKVAQAEA PRVPYQSEPN WARTAREKSE RARSKTPADP HTAYRPASSP
    210 220 230 240 250
    APANHPVHAE NAREHAEKSK VFTHNINEPF GRSYWEASNT VPRYGRSHSV
    260 270 280 290 300
    GRELYNRGYE LGGMDYTGGI HVDHGTDYQY YEEPARKPQT PKLPPGYELG
    310 320 330 340 350
    GTDFYKGHVP GDANYRGHGP DPPRLRPKYT ADSHDPCNVA IAPNLEGVDA
    360 370 380 390 400
    NLLVGDTLSN QKIRHEVRHI DQTKFGTSFG PTKGFSYDHH TVPRYVEPPK
    410 420 430 440 450
    PVVYSLSANK SLARSASVPR SSAPPEQRDV WNIQQSEVDK ETYITEPNWR
    460 470 480 490 500
    RNVDQRRLAW ERRAFETEQH LSRPYSEKVA PGVPPAWHAE AQHKHQQWQQ
    510 520 530 540 550
    QADNMNTQNY TYSTTGYQPS QPSGGQQSYN ETRQYSSNAT SNYPSQTQQY
    560 570 580 590 600
    QQQQHQYQSD HSNAQRLLNS GYNTNQVDYV LGHKDKYNEG PHYQPPIINS
    610 620 630 640 650
    SATAANNSSS STHHYNSSSQ AIPLGGPNQG HSSSSYTTET RVTGGGTGAP
    660 670 680 690 700
    VSNNYSNQNY SSSAYNSQSS QHQTKSIPVQ NYQNSQKSFQ ESSEKFHRDL
    710 720 730 740 750
    ASPLSRTIPV QSAGHFSEVS KYFNSEETNH ESRQESRCHS EVAETTETSE
    760 770 780 790 800
    KKEENYQVSQ PAIPLPSADQ VYESSNYNKS YSSQTTTQHQ PQPVAANNNY
    810 820 830 840 850
    STSYHTERSS TTTAQQPQTI ALPPPQNNSS HTETHSSTGP IMMHSPGGHS
    860 870 880 890 900
    MKSTEFSSSR HHKQETTTTT TTTPQPPVFQ TTTYPTTKTT SYNYSSSTIP
    910 920 930 940 950
    SQPAKPSFNQ ESYTTHTERN NSSQGFPQQR LQPSGGYSYE NYSSSRKEEN
    960 970 980 990 1000
    RREETSRPVS QLSQYSESRN YKRNYEEKTE TTTVPSLAPA TNVTYKDLSN
    1010 1020 1030 1040 1050
    AQCVDDVFNK KTEMNESLPV GSVFNTHNNT EGGYRDANGH DVSYKRETQT
    1060 1070 1080 1090 1100
    SADPGRETAL LKEEEKRVVE TPLEPGVISR HVTTKYYKKK TVTDTTTTTA
    Length:1,100
    Mass (Da):123,558
    Last modified:February 19, 2014 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9DD786010BB3D43B
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 19 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    H2KZA3H2KZA3_CAEEL
    Prion-like-(Q/N-rich)-domain-bearin...
    pqn-22 C46G7.4, CELE_C46G7.4
    1,165Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    V6CLQ4V6CLQ4_CAEEL
    Prion-like-(Q/N-rich)-domain-bearin...
    pqn-22 C46G7.4, CELE_C46G7.4
    971Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    V6CLV0V6CLV0_CAEEL
    Prion-like-(Q/N-rich)-domain-bearin...
    pqn-22 C46G7.4, CELE_C46G7.4
    1,061Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    H2KZA4H2KZA4_CAEEL
    Prion-like-(Q/N-rich)-domain-bearin...
    pqn-22 C46G7.4, CELE_C46G7.4
    925Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    V6CKJ1V6CKJ1_CAEEL
    Prion-like-(Q/N-rich)-domain-bearin...
    pqn-22 C46G7.4, CELE_C46G7.4
    1,056Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    Q9TY23Q9TY23_CAEEL
    Prion-like-(Q/N-rich)-domain-bearin...
    pqn-22 C46G7.4, CELE_C46G7.4
    615Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    V6CLU8V6CLU8_CAEEL
    Prion-like-(Q/N-rich)-domain-bearin...
    pqn-22 C46G7.4, CELE_C46G7.4
    1,010Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    V6CLV6V6CLV6_CAEEL
    Prion-like-(Q/N-rich)-domain-bearin...
    pqn-22 C46G7.4, CELE_C46G7.4
    946Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    V6CLQ8V6CLQ8_CAEEL
    Prion-like-(Q/N-rich)-domain-bearin...
    pqn-22 C46G7.4, CELE_C46G7.4
    1,146Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    V6CKH6V6CKH6_CAEEL
    Prion-like-(Q/N-rich)-domain-bearin...
    pqn-22 C46G7.4, CELE_C46G7.4
    1,080Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    There are more potential isoformsShow all

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    BX284604 Genomic DNA Translation: CDK13548.1

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001293808.1, NM_001306879.1

    Genome annotation databases

    Ensembl metazoan genome annotation project

    More...
    EnsemblMetazoai
    C46G7.4s; C46G7.4s; WBGene00004112

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    177369

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    BX284604 Genomic DNA Translation: CDK13548.1
    RefSeqiNP_001293808.1, NM_001306879.1

    3D structure databases

    SMRiV6CLV2
    ModBaseiSearch...
    MobiDBiSearch...

    Proteomic databases

    PeptideAtlasiV6CLV2

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsemblMetazoaiC46G7.4s; C46G7.4s; WBGene00004112
    GeneIDi177369

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    177369
    WormBaseiC46G7.4s ; CE49448 ; WBGene00004112 ; pqn-22

    Phylogenomic databases

    GeneTreeiENSGT00940000174270
    OrthoDBi211015at2759

    Gene expression databases

    BgeeiWBGene00004112 Expressed in 4 organ(s), highest expression level in multi-cellular organism
    ExpressionAtlasiV6CLV2 baseline and differential

    Family and domain databases

    InterProiView protein in InterPro
    IPR006643 Zasp-like_motif
    SMARTiView protein in SMART
    SM00735 ZM, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiV6CLV2_CAEEL
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: V6CLV2
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 19, 2014
    Last sequence update: February 19, 2014
    Last modified: June 5, 2019
    This is version 34 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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