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UniProtKB - V6CLJ5 (LAG1_CAEEL)

Entry version 56 (25 May 2022)
Sequence version 1 (19 Feb 2014)
Previous versions | rss
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Protein

Suppressor of hairless protein homolog

Gene

lag-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional regulator that plays a central role in lin-12/Notch and glp-1/Notch signaling pathways, involved in cell-cell communication that regulate a broad spectrum of cell-fate determinations (PubMed:8625826).

Binds directly to the 5'-[A/G]TGGGAA-3' DNA consensus sequence, which is present in the regulatory region of several genes (PubMed:8625826, PubMed:18706403, PubMed:23615264, PubMed:15297877, PubMed:32196486, PubMed:21737278).

Acts as a transcriptional repressor when it is not associated with Notch proteins (By similarity).

When in a complex with a Notch intracellular domain (NICD) product of lin-12/Notch or glp-1/Notch, and transcription regulator lag-3, it may act as a transcriptional activator that activates transcription of target genes(PubMed:18381292, PubMed:10830967, PubMed:32196486, PubMed:9003776).

Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively (By similarity).

Autonomously required in the germline for the stem cell fate, acting in the glp-1-dependent transcriptional activation of genes, including lst-1 and sygl-1 (PubMed:32196486).

Involved in cell-fate specification during reproductive system development, by positively autoregulating its own expression, in response to lin-12/Notch signaling (PubMed:23615264, PubMed:32839181).

Plays a role in Notch-dependent induction of left-right asymmetry in interneurons and motoneurons (PubMed:21737278).

May repress expression of hlh-6, in a lin-12/Notch-independent manner (PubMed:18706403).

By similarity9 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processNotch signaling pathway, Transcription, Transcription regulation

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		V6CLJ5

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Suppressor of hairless protein homologCurated
Alternative name(s):
CSL transcription factor lag-11 PublicationCurated
Lin-12 and glp-1 phenotype proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:lag-1Imported
ORF Names:K08B4.1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditina › Rhabditomorpha › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IV

Organism-specific databases

WormBase

More...WormBasei		K08B4.1a ; CE28839 ; WBGene00002245 ; lag-1
K08B4.1b ; CE25048 ; WBGene00002245 ; lag-1
K08B4.1c ; CE49374 ; WBGene00002245 ; lag-1
K08B4.1d ; CE49360 ; WBGene00002245 ; lag-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

RNAi-mediated knockdown ectopically up-regulates expression of hlh-6 outside pharyngeal gland cells.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi743 – 790Missing in q385; die as L1 larvae with cell transformations that result in the loss of the excretory cell, loss of the rectum and a twisted nose. 1 PublicationAdd BLAST48

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004522771 – 790Suppressor of hairless protein homologAdd BLAST790

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

In young adults, expressed in germ cells in the distal most ~10 cell diameters of the progenitor zone (PZ), and also in late pachytene, diplotene and diakinesis of oogenesis.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in the precursor anchor cell and ventral uterine precursor cell (Z1.ppp, Z1.ppa, Z4.aaa, and Z4.aap) before cell specification, at early larval stage L2 (PubMed:23615264). Expressed in the ventral uterine cell (VU), but not in the anchor cell (AC), after specification, at late larval stage L2 (PubMed:23615264). Expressed in a dynamic pattern in the vulval precursor cells (VPCs) during vulval induction in larval stage L3 (PubMed:32839181). Expressed in somatic gonad cells, the distal tip cell (DTC), and all sheath and spermathecal cells, as well as in polyploid intestinal cells, in both the larval L4 and adult stages.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		WBGene00002245, Expressed in multi-cellular organism and 5 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		V6CLJ5, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of a complex consisting of at least a lin-12/Notch intracellular domain (NICD), lag-1, and lag-3 (PubMed:16530045, PubMed:10830967, PubMed:18381292). An NICD product of lin-12/Notch, including the RBP-j associated molecule (RAM) and ankyrin repeat (ANK) domains, interacts directly with lag-1 (PubMed:16530045, PubMed:10830967, PubMed:18381292, PubMed:9003776).

3 Publications

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-3152, CSL-Notch-Mastermind transcription factor complex

Protein interaction database and analysis system

More...IntActi		V6CLJ5, 15 interactors

Molecular INTeraction database

More...MINTi		V6CLJ5

STRING: functional protein association networks

More...STRINGi		6239.K08B4.1a

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1790
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		V6CLJ5

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		V6CLJ5

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini680 – 776IPT/TIGBy similarityAdd BLAST97

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 27DisorderedSequence analysisAdd BLAST27
Regioni92 – 125DisorderedSequence analysisAdd BLAST34
Regioni343 – 353DNA-binding2 PublicationsAdd BLAST11
Regioni484 – 489DNA-binding2 Publications6
Regioni514 – 519DNA-binding2 Publications6

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Su(H) family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3743, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000005197

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_022207_1_0_1

Identification of Orthologs from Complete Genome Data

More...OMAi		IQFQATQ

Database of Orthologous Groups

More...OrthoDBi		444988at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.10, 1 hit
2.60.40.1450, 1 hit

Intrinsically Disordered proteins with Extensive Annotations and Literature

More...IDEALi		IID50096

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR015350, Beta-trefoil_DNA-bd_dom
IPR036358, BTD_sf
IPR040159, CLS_fam
IPR013783, Ig-like_fold
IPR014756, Ig_E-set
IPR008967, p53-like_TF_DNA-bd
IPR015351, RBP-J/Cbf11/Cbf12_DNA-bd
IPR037095, RBP-J/Cbf11_DNA-bd_sf
IPR038007, RBP-Jkappa_IPT

The PANTHER Classification System

More...PANTHERi		PTHR10665, PTHR10665, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF09270, BTD, 1 hit
PF09271, LAG1-DNAbind, 1 hit
PF20144, TIG_SUH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01268, BTD, 1 hit
SM01267, LAG1_DNAbind, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF110217, SSF110217, 1 hit
SSF49417, SSF49417, 1 hit
SSF81296, SSF81296, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform dImported (identifier: V6CLJ5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFSWRRGDCE SQKEENRSEE RKGEETIRFP TRSPFHCVLF LLTDGFVLHK 
        60         70         80         90        100
PTASPTVGFS PTIFSFYYSR WESSHRISHD ESGFCTAKTP LQDSTFTRHP 
       110        120        130        140        150
STSVPSSPST PRHSGMDYHQ SSSVASSEST ASTVAAAAAA AAAASLNQHH 
       160        170        180        190        200
HPHLYCDDGL LSRSLTDMVS SGGYDSSSSS LSAAASMCYP TPDAYYYHAP 
       210        220        230        240        250
PPPPPPQAQQ GFSSTDAWLQ MQMQPTYHNF GSTVVSTNSP LPSHLLSYGG 
       260        270        280        290        300
QPAFADPFYT IGQSTPNTSS FLDTSNSSFG APSTVVANPM TNYQLAFQAK 
       310        320        330        340        350
LGSLHSLIGD SVQSLTSDRM IDFLSNKEKY ECVISIFHAK VAQKSYGNEK 
       360        370        380        390        400
RFFCPPPCIY LIGQGWKLKK DRVAQLYKTL KASAQKDAAI ENDPIHEQQA 
       410        420        430        440        450
TELVAYIGIG SDTSERQQLD FSTGKVRHPG DQRQDPNIYD YCAAKTLYIS 
       460        470        480        490        500
DSDKRKYFDL NAQFFYGCGM EIGGFVSQRI KVISKPSKKK QSMKNTDCKY 
       510        520        530        540        550
LCIASGTKVA LFNRLRSQTV STRYLHVEGN AFHASSTKWG AFTIHLFDDE 
       560        570        580        590        600
RGLQETDNFA VRDGFVYYGS VVKLVDSVTG IALPRLRIRK VDKQQVILDA 
       610        620        630        640        650
SCSEEPVSQL HKCAFQMIDN ELVYLCLSHD KIIQHQATAI NEHRHQINDG 
       660        670        680        690        700
AAWTIISTDK AEYRFFEAMG QVANPISPCP VVGSLEVDGH GEASRVELHG 
       710        720        730        740        750
RDFKPNLKVW FGATPVETTF RSEESLHCSI PPVSQVRNEQ THWMFTNRTT 
       760        770        780        790
GDVEVPISLV RDDGVVYSSG LTFSYKSLER HGPCRIVSNY
Length:790
Mass (Da):87,732
Last modified:February 19, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAB0EB34D3FCE4EC8
GO
Isoform bImported (identifier: V6CLJ5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-255: MFSWRRGDCE...LSYGGQPAFA → MPLAYSTHDN...DQSKNSPTNS

Show »
Length:671
Mass (Da):74,750
Checksum:i560701A892830E47
GO
Isoform aImported (identifier: V6CLJ5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-255: MFSWRRGDCE...LSYGGQPAFA → MPLAYSTHDN...DQSKNSPTNS

Show »
Length:673
Mass (Da):74,947
Checksum:i72B236C29ECAE0B6
GO
Isoform cImported (identifier: V6CLJ5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-255: MFSWRRGDCE...LSYGGQPAFA → MFQSVSPLAG...DQSKNSPTNS

Show »
Length:627
Mass (Da):69,671
Checksum:i72C65D630427B45B
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0609461 – 255MFSWR…QPAFA → MPLAYSTHDNFYESPKTPQP TWDHVHAQFPLGEPARNLDK FIVPEAMFQSVSPLAGVAAA PSQIAALQQIQALMTFQMQQ NNLFPKIDTISKSPTPELAS PSAKRMRLSPSTSSHSDVAS TSKGTNGQDQSKNSPTNS in isoform a. Add BLAST255
Alternative sequenceiVSP_0609471 – 255MFSWR…QPAFA → MPLAYSTHDNFYESPKTPQP TWDHVHAQFPLGEPARNLDK FIEAMFQSVSPLAGVAAAPS QIAALQQIQALMTFQMQQNN LFPKIDTISKSPTPELASPS AKRMRLSPSTSSHSDVASTS KGTNGQDQSKNSPTNS in isoform b. Add BLAST255
Alternative sequenceiVSP_0609481 – 255MFSWR…QPAFA → MFQSVSPLAGVAAAPSQIAA LQQIQALMTFQMQQNNLFPK IDTISKSPTPELASPSAKRM RLSPSTSSHSDVASTSKGTN GQDQSKNSPTNS in isoform c. Add BLAST255

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
BX284604 Genomic DNA Translation: CCD72375.1
BX284604 Genomic DNA Translation: CCD72376.1
BX284604 Genomic DNA Translation: CDK13424.1
BX284604 Genomic DNA Translation: CDK13425.1
U49794 mRNA Translation: AAB03858.1
U49795 Genomic DNA Translation: AAB03859.1

Protein sequence database of the Protein Information Resource

More...PIRi		T33741

NCBI Reference Sequences

More...RefSeqi		NP_001023278.1, NM_001028107.3 [V6CLJ5-2]
NP_001293739.1, NM_001306810.1
NP_001293740.1, NM_001306811.1 [V6CLJ5-1]
NP_741410.1, NM_171350.4 [V6CLJ5-3]

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		K08B4.1a.1; K08B4.1a.1; WBGene00002245 [V6CLJ5-3]
K08B4.1b.1; K08B4.1b.1; WBGene00002245 [V6CLJ5-2]
K08B4.1c.1; K08B4.1c.1; WBGene00002245 [V6CLJ5-4]
K08B4.1d.1; K08B4.1d.1; WBGene00002245 [V6CLJ5-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		177373

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		cel:CELE_K08B4.1

UCSC genome browser

More...UCSCi		K08B4.1a, c. elegans

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA Translation: CCD72375.1
BX284604 Genomic DNA Translation: CCD72376.1
BX284604 Genomic DNA Translation: CDK13424.1
BX284604 Genomic DNA Translation: CDK13425.1
U49794 mRNA Translation: AAB03858.1
U49795 Genomic DNA Translation: AAB03859.1
PIRiT33741
RefSeqiNP_001023278.1, NM_001028107.3 [V6CLJ5-2]
NP_001293739.1, NM_001306810.1
NP_001293740.1, NM_001306811.1 [V6CLJ5-1]
NP_741410.1, NM_171350.4 [V6CLJ5-3]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1TTUX-ray2.85A309-780[»]
2FO1X-ray3.12A309-780[»]
3BRDX-ray2.21A309-780[»]
AlphaFoldDBiV6CLJ5
SMRiV6CLJ5
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-3152, CSL-Notch-Mastermind transcription factor complex
IntActiV6CLJ5, 15 interactors
MINTiV6CLJ5
STRINGi6239.K08B4.1a

Genome annotation databases

EnsemblMetazoaiK08B4.1a.1; K08B4.1a.1; WBGene00002245 [V6CLJ5-3]
K08B4.1b.1; K08B4.1b.1; WBGene00002245 [V6CLJ5-2]
K08B4.1c.1; K08B4.1c.1; WBGene00002245 [V6CLJ5-4]
K08B4.1d.1; K08B4.1d.1; WBGene00002245 [V6CLJ5-1]
GeneIDi177373
KEGGicel:CELE_K08B4.1
UCSCiK08B4.1a, c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		177373
WormBaseiK08B4.1a ; CE28839 ; WBGene00002245 ; lag-1
K08B4.1b ; CE25048 ; WBGene00002245 ; lag-1
K08B4.1c ; CE49374 ; WBGene00002245 ; lag-1
K08B4.1d ; CE49360 ; WBGene00002245 ; lag-1

Phylogenomic databases

eggNOGiKOG3743, Eukaryota
GeneTreeiENSGT00390000005197
HOGENOMiCLU_022207_1_0_1
OMAiIQFQATQ
OrthoDBi444988at2759

Enzyme and pathway databases

SignaLinkiV6CLJ5

Gene expression databases

BgeeiWBGene00002245, Expressed in multi-cellular organism and 5 other tissues
ExpressionAtlasiV6CLJ5, baseline and differential

Family and domain databases

Gene3Di2.60.40.10, 1 hit
2.60.40.1450, 1 hit
IDEALiIID50096
InterProiView protein in InterPro
IPR015350, Beta-trefoil_DNA-bd_dom
IPR036358, BTD_sf
IPR040159, CLS_fam
IPR013783, Ig-like_fold
IPR014756, Ig_E-set
IPR008967, p53-like_TF_DNA-bd
IPR015351, RBP-J/Cbf11/Cbf12_DNA-bd
IPR037095, RBP-J/Cbf11_DNA-bd_sf
IPR038007, RBP-Jkappa_IPT
PANTHERiPTHR10665, PTHR10665, 1 hit
PfamiView protein in Pfam
PF09270, BTD, 1 hit
PF09271, LAG1-DNAbind, 1 hit
PF20144, TIG_SUH, 1 hit
SMARTiView protein in SMART
SM01268, BTD, 1 hit
SM01267, LAG1_DNAbind, 1 hit
SUPFAMiSSF110217, SSF110217, 1 hit
SSF49417, SSF49417, 1 hit
SSF81296, SSF81296, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLAG1_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: V6CLJ5
Secondary accession number(s): G5EDU7, Q8MXE7, V6CK60
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 7, 2021
Last sequence update: February 19, 2014
Last modified: May 25, 2022
This is version 56 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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