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Entry version 57 (12 Aug 2020)
Sequence version 1 (19 Feb 2014)
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Protein

E3 ubiquitin-protein ligase hecd-1

Gene

hecd-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (By similarity). Involved in the ubiquitination and proteasomal-mediated degradation of cytoplasmic and mitochondrial proteins (PubMed:24703696, PubMed:21673654). Positively regulates lin-12 activity in the anchor cell (AC)/vulval precursor (VU) cell fate decision (PubMed:25552605). Negatively regulates glp-1 activity in germline proliferation (PubMed:25552605). May play a role in the formation of fibrous organelles, a hemidesmosome-like structure attaching muscles to the epidermis (PubMed:20153198). Regulates germline DNA double-strand-break repair and apoptosis in response to DNA damage by recruiting E4 ubiquitin-protein ligase ufd-2 to DNA repair foci (PubMed:27669035).By similarity5 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.By similarity EC:2.3.2.26

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.2 Publications
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei2617Glycyl thioester intermediatePROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
E3 ubiquitin-protein ligase hecd-1Curated (EC:2.3.2.26By similarity)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:hecd-11 PublicationImported
ORF Names:C34D4.14Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IV

Organism-specific databases

WormBase

More...
WormBasei
C34D4.14a ; CE49267 ; WBGene00016405 ; hecd-1

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

RNAi-mediated knockdown causes no visible phenotype (PubMed:20153198). RNAi-mediated knockdown in a glp-1(ar202) mutant background causes an increase in the number of sterile animals (PubMed:25552605). RNAi-mediated knockdown in a vab-10(e698) mutant background causes 50 percent larval lethality associated with the detachment of muscles from the epidermis (PubMed:20153198).2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi977A → T in hh2; loss of degradation of ubiquitinated proteins; when associated with 1304-W--N-2648 DEL. 1 Publication1
Mutagenesisi1304 – 2648Missing in hh2; loss of degradation of ubiquitinated proteins; when associated with T-977. 1 PublicationAdd BLAST1345
Mutagenesisi1460 – 2648Missing in hh3; loss of degradation of ubiquitinated proteins. 1 PublicationAdd BLAST1189
Mutagenesisi2282 – 2648Missing in hh4; loss of degradation of ubiquitinated proteins. 1 PublicationAdd BLAST367

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004444321 – 2648E3 ubiquitin-protein ligase hecd-1Add BLAST2648

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
V6CLA2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
V6CLA2

PeptideAtlas

More...
PeptideAtlasi
V6CLA2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in most tissues, including hypodermis, muscle, intestine, vulva, and neurons.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00016405, Expressed in multi-cellular organism and 3 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
V6CLA2, baseline and differential

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati374 – 403ANK 1Sequence analysisAdd BLAST30
Repeati405 – 434ANK 2Sequence analysisAdd BLAST30
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1438 – 1510MIB/HERC2PROSITE-ProRule annotationAdd BLAST73
Domaini2240 – 2648HECTPROSITE-ProRule annotationAdd BLAST409

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi673 – 738Ser-richPROSITE-ProRule annotationAdd BLAST66
Compositional biasi1688 – 1693Poly-GlnSequence analysis6
Compositional biasi1737 – 1780Asp-richPROSITE-ProRule annotationAdd BLAST44

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the UPL family. K-HECT subfamily.Curated

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156572

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000869_0_0_1

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00078, HECTc, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 1 hit
1.25.40.20, 1 hit
2.30.30.920, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR008979, Galactose-bd-like_sf
IPR000569, HECT_dom
IPR035983, Hect_E3_ubiquitin_ligase
IPR010606, Mib_Herc2
IPR037252, Mib_Herc2_sf
IPR012919, SUN_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796, Ank_2, 1 hit
PF00632, HECT, 1 hit
PF06701, MIB_HERC2, 1 hit
PF07738, Sad1_UNC, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248, ANK, 2 hits
SM00119, HECTc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF159034, SSF159034, 1 hit
SSF48371, SSF48371, 1 hit
SSF48403, SSF48403, 1 hit
SSF49785, SSF49785, 1 hit
SSF56204, SSF56204, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 1 hit
PS50237, HECT, 1 hit
PS51416, MIB_HERC2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

V6CLA2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDGIDPETLL EWLQTGIGDE RDLQLMALEQ LCMLLLMADN IDRCFESCPP
60 70 80 90 100
RTFIPALCKI FIDETAPDNV LEVTARAITY YLDVSNECTR RITQVDGAVK
110 120 130 140 150
AICTRLAAAD ISDRSSKDLA EQCVKLLEHV CQRETMAVYD AGGINAMLTL
160 170 180 190 200
VRVHGTQVHK DTMHSAMSVV TRLCGKMEPT DPELGKCAES LGALLEHEDP
210 220 230 240 250
KVSESALRCF AALTDRFVRK MMDPAELAMH SNLVEHLISI MVASNDENSP
260 270 280 290 300
TTASANILSI VLSLIGNLCR GSSLITEKVL TSPNMITGLK ATLTNKEERV
310 320 330 340 350
VTDGLRFCDL LLVLLCEGRS ALPLTSVVSG DYAAGSGAER VHRQLIDAIR
360 370 380 390 400
QKDLTALVDA IESGQVDVNF ADDVGQSLTN WASAFGSIEM VQYLCDKGSD
410 420 430 440 450
VNKGHKSSSL HYAACFGRPD VVKLLLQRGA NPDLRDEDGK TALDKARERS
460 470 480 490 500
DDDHNQVANI LESPSAFMRN KEDPKVKAST SKQPGTSTKP ELPNPNLVRK
510 520 530 540 550
VLHQLLPIFC EIFQKSLNGS VRRTSLSLMR KIVENIGDLR QSAVGDGNAP
560 570 580 590 600
AAQSARKMST DVSAGAESLV AVVVSVMDQE DDHEGHEQVL LILESLLEKD
610 620 630 640 650
AELWVIELVR LGVFERVEAM AKEPPKGLEE VLNAIHLEGR SRVTPMEIDF
660 670 680 690 700
ENQPSSSTAV PTANDIMDTT VPSSSGGADA ESNSNPSTIE MADPESSTPS
710 720 730 740 750
SSTQQSISKP KATASSTASS AILQVVSKLS SVASLDKSAA AVDKKPTKTV
760 770 780 790 800
LSQGTPYRWK EWRIVRGTTS LFIWSDVLLI ELPFQSNGWF RYLADNDSHV
810 820 830 840 850
QFVTGTASVD QQMTEEEKDN FQKTERREMV SRWNAVKGVF DDDWSSVPIA
860 870 880 890 900
VLGIPSNAKK VSQKLEVPAW ELWSSKSSEL QIKSISSSAP TGQANTMLTT
910 920 930 940 950
IKDDAGGFLF ETGTGRKTNV MPEHALPSDF HTGWSSHGVS TRKMKFRQDI
960 970 980 990 1000
QKRKVQELAW KLWNDHLKEA HAKPREALVR LENAARTIES TIRHVKAQSN
1010 1020 1030 1040 1050
FKHRNVKQPR IERVQEYCAA ISTLHESIVD DRRLSTFEFS VSGIVPALFG
1060 1070 1080 1090 1100
LLSMMEKFPD SFPSRIFKEQ FSKGEALSYL ALKIVAVLEA NEKFPQHLYD
1110 1120 1130 1140 1150
SPGGSSFGLQ LLSRRVRTKL EMLPRADGKE NNDENLVNKT GKIVKCEPLA
1160 1170 1180 1190 1200
SVGAIRAYLH RMVTRQWHDR ERANYRYVKE IQELKTKGKS IELRHVSDFD
1210 1220 1230 1240 1250
ENGVIYWIGT NGRAAPLWTN PATVKAVKIT CSDTRQPFGK PEDLLSRDQN
1260 1270 1280 1290 1300
PINCHTSDDK NAHFTIDLGL FVVPTSYSLR HSRGYGRSAL RNWMLQGSVD
1310 1320 1330 1340 1350
AKRWENVIVH TDDKGLGEPG STATWHVGEK GTTAFRFFRI AQNGKNSSGQ
1360 1370 1380 1390 1400
THYLSCSGFE IYGDIVDVVT EAICEDPPKK DSPAGTSSTP GSSSSAALPP
1410 1420 1430 1440 1450
LTKEQVLEML PARENNNRLK SGLSLETVTS MLQRSRHRSR GSYKISESKS
1460 1470 1480 1490 1500
KVVRGKDWRW EDQDGGEGKF GRITSPPESG WVDVTWDNGN ANSYRFGANG
1510 1520 1530 1540 1550
NFDIERVTST GHRYSTPSLA SHVPTSVMEA VRRNRAFYTP KTTGGPPSSS
1560 1570 1580 1590 1600
VFGTSSSAGS SRGAASALSR FASVKNTTPA GTPSSGGSSG GAIGKKSMST
1610 1620 1630 1640 1650
TNLVDERQKT SGPSVASTGQ AASAESLQHQ TPSLENLLAR AMPHAFGRIA
1660 1670 1680 1690 1700
ENQEPEDEPM GGEESDSAAS MRSAASSNSQ MSMGSSSQQQ QQQDSDMTPR
1710 1720 1730 1740 1750
DSAGTPSTPR DDKNQTLSVS APDLAAARQR QASAETDGDA DADETNSEDK
1760 1770 1780 1790 1800
TVGADDAMEE DDEEEETMED EEDDDDDDDD ESSNENQEKL VELLGGERGL
1810 1820 1830 1840 1850
FDKLKEVITG ESLSDASSSA KDATTNEAQK KGGKKPKKWF KKMSSYTDVL
1860 1870 1880 1890 1900
KGLMQNRYPV ALLDPAAAGI EMDEMMDDDD YYDFSEDGPD DGDSVEDEVA
1910 1920 1930 1940 1950
AHLGMPVDSF ASMVAARTPI TWRQFSELMS GSNRERAAMA RAVASSRGSP
1960 1970 1980 1990 2000
WEDDATVKCT FEALIPAFDP RPGRSNVNQT LEVELPTVVK DFGSTKASSS
2010 2020 2030 2040 2050
KIDKDDQMRF FLRGPNMSGV DNVTIEMNDD SASLFRYMQI INNSVNWATK
2060 2070 2080 2090 2100
SDRSRRIWEP TYSICYCSAD QTNVEVSKIP DEESSTPCQV NQCLETIGLL
2110 2120 2130 2140 2150
SRIQQAMPEA EITPNVFISD KLTLKVTQVL SDALVVAARS LPEWCSRLVY
2160 2170 2180 2190 2200
KYPCLFTVET RNMYMQATAF GVSRTIVWLQ QRRDAAVERA RGSAQAGNSS
2210 2220 2230 2240 2250
AARQHDRYHE YRVGRLRHER VKVTRAEETL LDQAIRLMKF HADRKAVLEI
2260 2270 2280 2290 2300
EYTNEEGTGL GPTLEFYALV AAELQRKSLA LWVCDDDDTH ASKSGEEREV
2310 2320 2330 2340 2350
DLGEGKKPIG YYVRRVGGLF PAPLPPGTDE TKRAADMFRV LGVFLAKVLL
2360 2370 2380 2390 2400
DGRLVDLPLS RPFLKLLVHP QIGDDARGPN LHKILSLDDF EEVNPVKGSF
2410 2420 2430 2440 2450
LKELRALAQR KRLIENDTSI DSNSKRRKIA ELKLHIKGST CRVEDLALNF
2460 2470 2480 2490 2500
TVNPPSKVFQ YAEMELVDGG SDIDVTIDNV EQYVEKCEEF YLNTGIAYQM
2510 2520 2530 2540 2550
RAFRDGFDRV FPLRTLRAYS PEEVQRLLSG EQCPEWSRDD ILNYTEPKLG
2560 2570 2580 2590 2600
YTRESPGFLR FVDVMEALTA QERKNFLQFA TGCSSLPPGG LANLHPRLTI
2610 2620 2630 2640
VRKVESGDGS YPSVNTCVHY LKLPEYSSSA ILRERLLTAI NEKGFHLN
Length:2,648
Mass (Da):292,210
Last modified:February 19, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDD84EE54AB8E9922
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
V6CLA7V6CLA7_CAEEL
HECT-type E3 ubiquitin transferase
hecd-1 C34D4.14, CELE_C34D4.14
2,650Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V6CJX7V6CJX7_CAEEL
HECT-type E3 ubiquitin transferase
hecd-1 C34D4.14, CELE_C34D4.14
2,644Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V6CLC0V6CLC0_CAEEL
HECT-type E3 ubiquitin transferase
hecd-1 C34D4.14, CELE_C34D4.14
2,646Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V6CIS4V6CIS4_CAEEL
HECT-type E3 ubiquitin transferase
hecd-1 C34D4.14, CELE_C34D4.14
2,607Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V6CL74V6CL74_CAEEL
HECT-type E3 ubiquitin transferase
hecd-1 C34D4.14, CELE_C34D4.14
2,611Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V6CIS8V6CIS8_CAEEL
HECT-type E3 ubiquitin transferase
hecd-1 C34D4.14, CELE_C34D4.14
2,609Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V6CL75V6CL75_CAEEL
HECT-type E3 ubiquitin transferase
hecd-1 C34D4.14, CELE_C34D4.14
2,613Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
BX284604 Genomic DNA Translation: CDK13339.1

NCBI Reference Sequences

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RefSeqi
NP_001293688.1, NM_001306759.1

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
C34D4.14a.1; C34D4.14a.1; WBGene00016405
C34D4.14a.2; C34D4.14a.2; WBGene00016405

Database of genes from NCBI RefSeq genomes

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GeneIDi
177486

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA Translation: CDK13339.1
RefSeqiNP_001293688.1, NM_001306759.1

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

EPDiV6CLA2
PaxDbiV6CLA2
PeptideAtlasiV6CLA2

Genome annotation databases

EnsemblMetazoaiC34D4.14a.1; C34D4.14a.1; WBGene00016405
C34D4.14a.2; C34D4.14a.2; WBGene00016405
GeneIDi177486

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
177486
WormBaseiC34D4.14a ; CE49267 ; WBGene00016405 ; hecd-1

Phylogenomic databases

GeneTreeiENSGT00940000156572
HOGENOMiCLU_000869_0_0_1

Enzyme and pathway databases

UniPathwayiUPA00143

Miscellaneous databases

Protein Ontology

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PROi
PR:V6CLA2

Gene expression databases

BgeeiWBGene00016405, Expressed in multi-cellular organism and 3 other tissues
ExpressionAtlasiV6CLA2, baseline and differential

Family and domain databases

CDDicd00078, HECTc, 1 hit
Gene3Di1.25.10.10, 1 hit
1.25.40.20, 1 hit
2.30.30.920, 1 hit
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR008979, Galactose-bd-like_sf
IPR000569, HECT_dom
IPR035983, Hect_E3_ubiquitin_ligase
IPR010606, Mib_Herc2
IPR037252, Mib_Herc2_sf
IPR012919, SUN_dom
PfamiView protein in Pfam
PF12796, Ank_2, 1 hit
PF00632, HECT, 1 hit
PF06701, MIB_HERC2, 1 hit
PF07738, Sad1_UNC, 1 hit
SMARTiView protein in SMART
SM00248, ANK, 2 hits
SM00119, HECTc, 1 hit
SUPFAMiSSF159034, SSF159034, 1 hit
SSF48371, SSF48371, 1 hit
SSF48403, SSF48403, 1 hit
SSF49785, SSF49785, 1 hit
SSF56204, SSF56204, 1 hit
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 1 hit
PS50237, HECT, 1 hit
PS51416, MIB_HERC2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHECD1_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: V6CLA2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2018
Last sequence update: February 19, 2014
Last modified: August 12, 2020
This is version 57 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families
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