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Entry version 36 (31 Jul 2019)
Sequence version 1 (19 Feb 2014)
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Protein
Submitted name:

Regulatory A subunit of protein phosphatase 2A

Gene

paa-1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Regulatory A subunit of protein phosphatase 2AImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:paa-1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00003901 Expressed in 5 organ(s), highest expression level in multi-cellular organism

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
V5XY55

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati14 – 52HEATPROSITE-ProRule annotationAdd BLAST39
Repeati168 – 205HEATPROSITE-ProRule annotationAdd BLAST38
Repeati246 – 284HEATPROSITE-ProRule annotationAdd BLAST39
Repeati285 – 322HEATPROSITE-ProRule annotationAdd BLAST38
Repeati367 – 405HEATPROSITE-ProRule annotationAdd BLAST39
Repeati406 – 444HEATPROSITE-ProRule annotationAdd BLAST39
Repeati484 – 522HEATPROSITE-ProRule annotationAdd BLAST39
Repeati523 – 561HEATPROSITE-ProRule annotationAdd BLAST39

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0211 Eukaryota
ENOG410XQVI LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00950000183066

KEGG Orthology (KO)

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KOi
K03456

Identification of Orthologs from Complete Genome Data

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OMAi
FIPLTIR

Database of Orthologous Groups

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OrthoDBi
447572at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
V5XY55

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR000357 HEAT
IPR021133 HEAT_type_2

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02985 HEAT, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF48371 SSF48371, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50077 HEAT_REPEAT, 8 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

V5XY55-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSVVEEATDD ALYPIAVLID ELRNEDVTLR LNSIRKLSTI ALALGVERTR
60 70 80 90 100
NELIQFLTDT IYDEDEVLLV LAEQLGNFTP LVGGPDHVHC LLLPLENLAT
110 120 130 140 150
VEETVVRDKA VESLRKIADK HSSASLEEHF VPMLRRLATG DWFTSRTSAC
160 170 180 190 200
GLFSVVYPRV SPAIKSELKS MFRTLCRDDT PMVRRAAAAK LGEFAKVFEK
210 220 230 240 250
TAVIEGLHSS LTDLHVDEQD SVRLLTVESA IAFGTLLDKA NKKKLIEPIL
260 270 280 290 300
IELFDDKSWR VRYMVAEKLI EIQNVLGEDM DTTHLVNMYT NLLKDPEGEV
310 320 330 340 350
RCAATQRLQE FALNLPEDKR QNIICNSLLN VAKELVTDGN QLVKSELAGV
360 370 380 390 400
IMGLAPLIGK EQTVSELLPI YMQLLNDQTP EVRLNIISSL DKVNEVIGAA
410 420 430 440 450
QLSTSLLPAI VGLAEDGKWR VRLAIVQFMP LLASQLGQEF FDEKLLPLCL
460 470 480 490 500
NWLTDHVFSI REASTLIMKE LTQKFGGQWA STNIVPKMQK LQKDTNYLQR
510 520 530 540 550
MTCLFCLNTL SEAMTQEQIL KEIMPIVKDL VEDDVPNVRF NAAKSLKRIG
560 570 580 590
KNLTPSTLTS EVKPLLEKLG KDSDFDVRYF SEEAKNSLGL
Length:590
Mass (Da):66,149
Last modified:February 19, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE9B6F7DFFEB973E2
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB110419 mRNA Translation: BAO09599.1

NCBI Reference Sequences

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RefSeqi
NP_498162.2, NM_065761.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
F48E8.5.1; F48E8.5.1; WBGene00003901
F48E8.5.2; F48E8.5.2; WBGene00003901

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
175750

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_F48E8.5

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB110419 mRNA Translation: BAO09599.1
RefSeqiNP_498162.2, NM_065761.4

3D structure databases

SMRiV5XY55
ModBaseiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF48E8.5.1; F48E8.5.1; WBGene00003901
F48E8.5.2; F48E8.5.2; WBGene00003901
GeneIDi175750
KEGGicel:CELE_F48E8.5

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
175750

Phylogenomic databases

eggNOGiKOG0211 Eukaryota
ENOG410XQVI LUCA
GeneTreeiENSGT00950000183066
KOiK03456
OMAiFIPLTIR
OrthoDBi447572at2759
PhylomeDBiV5XY55

Gene expression databases

BgeeiWBGene00003901 Expressed in 5 organ(s), highest expression level in multi-cellular organism

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR000357 HEAT
IPR021133 HEAT_type_2
PfamiView protein in Pfam
PF02985 HEAT, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS50077 HEAT_REPEAT, 8 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiV5XY55_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: V5XY55
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 19, 2014
Last sequence update: February 19, 2014
Last modified: July 31, 2019
This is version 36 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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