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Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Burkholderia cenocepacia KC-01
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotationSAAS annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotationSAAS annotation

Pathwayi: 7,8-dihydroneopterin triphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP.UniRule annotationSAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. GTP cyclohydrolase FolE2 (folE2), GTP cyclohydrolase 1 (folE), GTP cyclohydrolase FolE2 (folE2)
This subpathway is part of the pathway 7,8-dihydroneopterin triphosphate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP, the pathway 7,8-dihydroneopterin triphosphate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei171May be catalytically importantUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotationImported

Enzyme and pathway databases

UniPathwayiUPA00848; UER00151

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2UniRule annotation
ORF Names:P355_0031Imported
OrganismiBurkholderia cenocepacia KC-01Imported
Taxonomic identifieri1396830 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
Proteomesi
  • UP000032887 Componenti: Unassembled WGS sequence

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotationSAAS annotation

Family and domain databases

HAMAPiMF_01527_B GTP_cyclohydrol_B, 1 hit
InterProiView protein in InterPro
IPR022838 GTP_cyclohydrolase_FolE2
IPR003801 GTP_cyclohydrolase_FolE2/MptA
PANTHERiPTHR36445 PTHR36445, 1 hit
PfamiView protein in Pfam
PF02649 GCHY-1, 1 hit

Sequencei

Sequence statusi: Complete.

V5A3E2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMRRARRRTR GLQGLNKMNQ MNPAFVMPDV QSTVDTRQIP IQRVGVKAVR
60 70 80 90 100
HPLTVCTESG DVQPTVGVWN LDVRLPADQK GTHMSRFVAL LEENRAPLTV
110 120 130 140 150
ERFRAMLASM LVKLEAEAGR IEVTFPYFVN KTAPVSGVQS LLDYEVTLAG
160 170 180 190 200
ESRNGDTRLF LKVLVPVTSL CPCSKKISQY GAHNQRSHVT IDAELAADLP
210 220 230 240 250
VEALIRIAEE EASCELWGLL KRPDEKFVTE RAYENPKFVE DLVRDVAQRL
260 270 280
DADERVVAYV LEAENFESIH NHSAYALIER DKRHAA
Length:286
Mass (Da):32,235
Last modified:January 22, 2014 - v1
Checksum:i9BACDDB02982BCFC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AWOP01000001 Genomic DNA Translation: ESS41768.1

Genome annotation databases

EnsemblBacteriaiESS41768; ESS41768; P355_0031
PATRICifig|1396830.3.peg.31

Similar proteinsi

Entry informationi

Entry nameiV5A3E2_9BURK
AccessioniPrimary (citable) accession number: V5A3E2
Entry historyiIntegrated into UniProtKB/TrEMBL: January 22, 2014
Last sequence update: January 22, 2014
Last modified: July 18, 2018
This is version 24 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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