Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Burkholderia cenocepacia KC-01
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotationSAAS annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotationSAAS annotation

Pathwayi: 7,8-dihydroneopterin triphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP.UniRule annotationSAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. GTP cyclohydrolase FolE2 (folE2), GTP cyclohydrolase 1 (folE), GTP cyclohydrolase FolE2 (folE2)
This subpathway is part of the pathway 7,8-dihydroneopterin triphosphate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP, the pathway 7,8-dihydroneopterin triphosphate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei166May be catalytically importantUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotationImported

Enzyme and pathway databases

UniPathwayi
UPA00848;UER00151

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2UniRule annotation
ORF Names:P355_0082Imported
OrganismiBurkholderia cenocepacia KC-01Imported
Taxonomic identifieri1396830 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
Proteomesi
  • UP000032887 Componenti: Unassembled WGS sequence

Structurei

3D structure databases

ProteinModelPortaliV4ZXD0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotationSAAS annotation

Family and domain databases

HAMAPiMF_01527_B GTP_cyclohydrol_B, 1 hit
InterProiView protein in InterPro
IPR022838 GTP_cyclohydrolase_FolE2
IPR003801 GTP_cyclohydrolase_FolE2/MptA
PANTHERiPTHR36445 PTHR36445, 1 hit
PfamiView protein in Pfam
PF02649 GCHY-1, 1 hit

Sequencei

Sequence statusi: Complete.

V4ZXD0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEKALHRISS MNAALPDISL TDAAPGRRPL EWVGMQGIDL PVVVAEPGCR
60 70 80 90 100
RDVHARADVQ VDLPAPQVKG IHMSRLYGLL DGLADGEALS PAGLQRMLRA
110 120 130 140 150
MVDSHRDCAT RSARVRLRFD LLARRTALVT EGLAGWKAYP VRLDATLAGD
160 170 180 190 200
AFALRAQVTV VYSSTCPCSA ALSRHWIEQA FLTAFGHEAR VEPAAVAAWL
210 220 230 240 250
KRHATAATPH SQRSEAVVSV ALPADGATLG LLDLIDRVEQ ALGTPVQTAV
260 270 280 290 300
KRADEQAFAV LNGGNLMFVE DAVRRVQAAL EDRHASPRVR VRHLESLHPH
310
DAVAWAAPLR QGADAC
Length:316
Mass (Da):34,067
Last modified:January 22, 2014 - v1
Checksum:i0DF79A3D1559AC25
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AWOP01000101 Genomic DNA Translation: ESS38126.1

Genome annotation databases

EnsemblBacteriaiESS38126; ESS38126; P355_0082
PATRICifig|1396830.3.peg.3849

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AWOP01000101 Genomic DNA Translation: ESS38126.1

3D structure databases

ProteinModelPortaliV4ZXD0
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiESS38126; ESS38126; P355_0082
PATRICifig|1396830.3.peg.3849

Enzyme and pathway databases

UniPathwayi
UPA00848;UER00151

Family and domain databases

HAMAPiMF_01527_B GTP_cyclohydrol_B, 1 hit
InterProiView protein in InterPro
IPR022838 GTP_cyclohydrolase_FolE2
IPR003801 GTP_cyclohydrolase_FolE2/MptA
PANTHERiPTHR36445 PTHR36445, 1 hit
PfamiView protein in Pfam
PF02649 GCHY-1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiV4ZXD0_9BURK
AccessioniPrimary (citable) accession number: V4ZXD0
Entry historyiIntegrated into UniProtKB/TrEMBL: January 22, 2014
Last sequence update: January 22, 2014
Last modified: October 10, 2018
This is version 28 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again