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Protein

RNA polymerase II transcription factor B subunit 2

Gene

EUTSA_v10025179mg

Organism
Eutrema salsugineum (Saltwater cress) (Sisymbrium salsugineum)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDNA damage, DNA repairUniRule annotation, Transcription, Transcription regulationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase II transcription factor B subunit 2UniRule annotation
Gene namesi
ORF Names:EUTSA_v10025179mgImported
OrganismiEutrema salsugineum (Saltwater cress) (Sisymbrium salsugineum)Imported
Taxonomic identifieri72664 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeEutremeaeEutrema
Proteomesi
  • UP000030689 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the TFB2 family.UniRule annotation

Phylogenomic databases

KOiK03144

Family and domain databases

InterProiView protein in InterPro
IPR004598 TFIIH_p52/Tfb2
PANTHERiPTHR13152 PTHR13152, 1 hit
PfamiView protein in Pfam
PF03849 Tfb2, 1 hit
TIGRFAMsiTIGR00625 tfb2, 1 hit

Sequencei

Sequence statusi: Complete.

V4MRC8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPQVKIIAKN FMDMVASLTA IKLDKLYNNV FICEAILRSL PPLAKKYVLQ
60 70 80 90 100
LLYTDVPVPA TMLEEWVLAD GVSKHRAAID RMIQLRIFME TTDRKKGTSY
110 120 130 140 150
SLNPTFQKNL QKHIISGGVL PREPMNSNNA IKLPSLQELE TYALQQWECF
160 170 180 190 200
LLQLINSGQG EKLTGISSSM MKIFQRGLLS QRDRDGPRLT ESGFQFLLMD
210 220 230 240 250
TNAQLWYIIR EYISNAEERD VDPAELISFL LELSFHVTGE AYNLNTLTEV
260 270 280 290 300
QRNTLKDLAD LGLVKLQQGR KDSWFIPTKL ATNLSVSLAD SSIRKEGYVM
310 320 330 340 350
METNFRMYAY STSKLQCEIL RLFARIEYQL PNLIACAITK ESLYNAFDNG
360 370 380 390 400
ITSDQIITFL QQNSHPRCAD RVPSIPENVT DQIRLWESDL KRIEMTQAHF
410 420 430 440 450
YDEFPSKDVF EAACDFAREW RGLLWEDSKR MRLVVKSEVH NKMREFLHTQ

SK
Length:452
Mass (Da):52,152
Last modified:January 22, 2014 - v1
Checksum:i2EE25EB939B0ED87
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KI517384 Genomic DNA Translation: ESQ55738.1
RefSeqiXP_006414285.1, XM_006414222.1

Genome annotation databases

GeneIDi18030691
KEGGieus:EUTSA_v10025179mg

Similar proteinsi

Entry informationi

Entry nameiV4MRC8_EUTSA
AccessioniPrimary (citable) accession number: V4MRC8
Entry historyiIntegrated into UniProtKB/TrEMBL: January 22, 2014
Last sequence update: January 22, 2014
Last modified: February 28, 2018
This is version 15 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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