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Entry version 34 (10 Apr 2019)
Sequence version 1 (22 Jan 2014)
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Protein
Submitted name:

Uncharacterized protein

Gene

EUTSA_v10006531mg

Organism
Eutrema salsugineum (Saltwater cress) (Sisymbrium salsugineum)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-bindingPROSITE-ProRule annotation
Biological processRNA-mediated gene silencingSAAS annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:EUTSA_v10006531mgImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEutrema salsugineum (Saltwater cress) (Sisymbrium salsugineum)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri72664 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeEutremeaeEutrema
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000030689 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
72664.XP_006418369.1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini265 – 442Helicase ATP-bindingInterPro annotationAdd BLAST178
Domaini660 – 821Helicase C-terminalInterPro annotationAdd BLAST162
Domaini849 – 944Dicer dsRNA-binding foldInterPro annotationAdd BLAST96
Domaini1189 – 1327PAZInterPro annotationAdd BLAST139
Domaini1370 – 1525RNase IIIInterPro annotationAdd BLAST156
Domaini1567 – 1715RNase IIIInterPro annotationAdd BLAST149
Domaini1741 – 1804DRBMInterPro annotationAdd BLAST64
Domaini1839 – 1914DRBMInterPro annotationAdd BLAST76

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the helicase family. Dicer subfamily.PROSITE-ProRule annotation

Phylogenomic databases

KEGG Orthology (KO)

More...
KOi
K11592

Database of Orthologous Groups

More...
OrthoDBi
1337630at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00048 DSRM, 1 hit
cd00079 HELICc, 1 hit
cd00593 RIBOc, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1520.10, 1 hit
3.30.160.380, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038248 Dicer_dimer_sf
IPR005034 Dicer_dimerisation_dom
IPR014720 dsRBD_dom
IPR006935 Helicase/UvrB_N
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR003100 PAZ_dom
IPR036085 PAZ_dom_sf
IPR000999 RNase_III_dom
IPR036389 RNase_III_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03368 Dicer_dimer, 1 hit
PF00035 dsrm, 1 hit
PF00271 Helicase_C, 1 hit
PF02170 PAZ, 1 hit
PF04851 ResIII, 1 hit
PF00636 Ribonuclease_3, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00487 DEXDc, 1 hit
SM00358 DSRM, 2 hits
SM00490 HELICc, 1 hit
SM00949 PAZ, 1 hit
SM00535 RIBOc, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF101690 SSF101690, 1 hit
SSF52540 SSF52540, 1 hit
SSF69065 SSF69065, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51327 DICER_DSRBF, 1 hit
PS50137 DS_RBD, 2 hits
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS50821 PAZ, 1 hit
PS00517 RNASE_3_1, 1 hit
PS50142 RNASE_3_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

V4L363-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVMEDERRGD IKPPSYWLDA CEDISCDLID DLVSDFDPSS VAVAESVDEN
60 70 80 90 100
GVNNDFFGGI DHILDSIKNG GGLPNRAHIN GVSETNSQRI NGNSEVSEAA
110 120 130 140 150
QLIAGETTVS VKGNVLQKCG GKRDEVSKEE GEKNRKRARV CSYQRERSNL
160 170 180 190 200
SGRGQANSRE GDRFMNRKRT RNWDEAGHNK RRDGYNYRRD GRDREARGYW
210 220 230 240 250
ERDKVGSNEL VYRSGTWEAD HERDLKKESG RNRESDEKAE ENKSKPEEHK
260 270 280 290 300
EKVVEEQARR YQLDVLEQAK AKNTIAFLET GAGKTLIAIL LIKSIHKDLT
310 320 330 340 350
SQNRKMLSVF LVPKVPLVYQ QAEVIRNQTC FQVGHYCGEM GQDFWDARRW
360 370 380 390 400
QREFESKQVL VMTAQILLNI LRHSIIRMEA INLLILDECH HAVKKHPYSL
410 420 430 440 450
VMSEFYHTTP KDKRPAIFGM TASPVNLKGV SSQVDCAIKI RNLETKLDST
460 470 480 490 500
VCTIKDRKEL EKHVPMPSEI VVEYDKAATM WSLHEKIKQM IAAVEEAAQA
510 520 530 540 550
SSRKSKWQFM GARDAGAKDE LRQVYGVSER TESDGAANLI HKLRAINYTL
560 570 580 590 600
AELGQWCAYK VAQSFLTALQ SDERVNFQVD VKFQESYLSE VVSLLQCELL
610 620 630 640 650
EGAAAEKAVA ELSKPENGNA NDEIEEGELP DDHVVSGGEH VDKVIGAAVA
660 670 680 690 700
DGKVTPKVQS LIKLLLKYQH TADFRAIVFV ERVVAALVLP KVFAELPSLG
710 720 730 740 750
FIRCASMIGH NNSQEMKSSQ MQDTISKFRD GQVTLLVATS VAEEGLDIRQ
760 770 780 790 800
CNVVMRFDLA KTVLAYIQSR GRARKPGSDY ILMVERENVS HAAFLRNARN
810 820 830 840 850
SEETLRKEAI ERTDLSHLKD SSRLISIDAV PGTVYKVEAT GAMVSLNSAV
860 870 880 890 900
GLIHFYCSQL PGDRYAILRP EFSMVKHEKP GGHTEYSCRL QLPCNAPFEI
910 920 930 940 950
LEGPVCSSMR LAQQAVCLAG CKKLHEMGAF TDMLLPDKGS GQDAEKADQD
960 970 980 990 1000
DEGEPIPGTA RHREFYPEGV ADVLKGEWIL SGKEICESSK LFHLYMYSVR
1010 1020 1030 1040 1050
CVDSGVSKDP FLTEVSEFAV LFGNELDAEV LSMSMDLYVA RAMITKASLA
1060 1070 1080 1090 1100
FRGSLDITES QLSSIKKFHV RLMSIVLDVD VEPSTTPWDP AKAYLFVPVA
1110 1120 1130 1140 1150
DNSSAEPIKG INWELVEKIT KTTVWDNPLQ RARPDVYLGT NERTLGGDRR
1160 1170 1180 1190 1200
EYGFGKLRHN IGFGQKSHPT YGIRGAVASF DVVRASGLLP VRDALEKEVE
1210 1220 1230 1240 1250
GDLSQGKLMM ADGCMVAENL LGKIVTAAHS GKRFYVDSIC YDMSAETSFP
1260 1270 1280 1290 1300
RKEGYLGPLE YNTYADYYKQ KYGVDLSCKQ QPLIKGRGVS YCKNLLSPRF
1310 1320 1330 1340 1350
EQSGESETIL DKTYYVFLPP ELCVVHPLSG SLVRGAQRLP SIMRRVESML
1360 1370 1380 1390 1400
LAVQLKNLIS YPIPTSKILE ALTAASCQET FCYERAELLG DAYLKWIVSR
1410 1420 1430 1440 1450
FLFLKYPQKH EGQLTRMRQQ MVSNLVLYQY ALVKGLQSYI QADRFAPSRW
1460 1470 1480 1490 1500
SAPGVPPVYD EDTKDGGSSF FDEEEKPEGN KDVFEDGEME DGELEGDLSS
1510 1520 1530 1540 1550
YRVLSSKTLA DVVEALIGVY YVEGGKTAAN HLMKWIGIHV EDDPEETEGS
1560 1570 1580 1590 1600
VKPVYNVPES VLKSIDFVGL ERALKYEFTE KGLLVEAITH ASRPSSGVSC
1610 1620 1630 1640 1650
YQRLEFVGDA VLDHLITRHL FFTYTSLPPG RLTDLRAAAV NNENFARVAV
1660 1670 1680 1690 1700
KHKLHLYLRH GSSALEKQIR DFVKEVLTES SKPGFNSFGL GDCKAPKVLG
1710 1720 1730 1740 1750
DIVESIAGAI FLDSGKDTTA AWKVFQPLLQ PMVTPETLPM HPVRELQERC
1760 1770 1780 1790 1800
QQQAEGLEYK ASRSGNTATV EVFIDGVQVG AAQNPQKKMA QKLAARNALA
1810 1820 1830 1840 1850
ALKEKEAEES KKKQANGNAA GENQDDNENG NKKNGNQTFT RQTLNDICLR
1860 1870 1880 1890 1900
KNWPMPSYRC VKEGGPAHAK RFTFGVRVNT SDRGWTDECI GEPMPSVKKA
1910
KDSAAILLLE LLNKTYS
Length:1,917
Mass (Da):214,106
Last modified:January 22, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD5AB4B3078C6091B
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
KI517683 Genomic DNA Translation: ESQ36722.1

NCBI Reference Sequences

More...
RefSeqi
XP_006418369.1, XM_006418306.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
18994635

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
eus:EUTSA_v10006531mg

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KI517683 Genomic DNA Translation: ESQ36722.1
RefSeqiXP_006418369.1, XM_006418306.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi72664.XP_006418369.1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi18994635
KEGGieus:EUTSA_v10006531mg

Phylogenomic databases

KOiK11592
OrthoDBi1337630at2759

Family and domain databases

CDDicd00048 DSRM, 1 hit
cd00079 HELICc, 1 hit
cd00593 RIBOc, 2 hits
Gene3Di1.10.1520.10, 1 hit
3.30.160.380, 1 hit
InterProiView protein in InterPro
IPR038248 Dicer_dimer_sf
IPR005034 Dicer_dimerisation_dom
IPR014720 dsRBD_dom
IPR006935 Helicase/UvrB_N
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR003100 PAZ_dom
IPR036085 PAZ_dom_sf
IPR000999 RNase_III_dom
IPR036389 RNase_III_sf
PfamiView protein in Pfam
PF03368 Dicer_dimer, 1 hit
PF00035 dsrm, 1 hit
PF00271 Helicase_C, 1 hit
PF02170 PAZ, 1 hit
PF04851 ResIII, 1 hit
PF00636 Ribonuclease_3, 2 hits
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00358 DSRM, 2 hits
SM00490 HELICc, 1 hit
SM00949 PAZ, 1 hit
SM00535 RIBOc, 2 hits
SUPFAMiSSF101690 SSF101690, 1 hit
SSF52540 SSF52540, 1 hit
SSF69065 SSF69065, 2 hits
PROSITEiView protein in PROSITE
PS51327 DICER_DSRBF, 1 hit
PS50137 DS_RBD, 2 hits
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS50821 PAZ, 1 hit
PS00517 RNASE_3_1, 1 hit
PS50142 RNASE_3_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiV4L363_EUTSA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: V4L363
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: January 22, 2014
Last sequence update: January 22, 2014
Last modified: April 10, 2019
This is version 34 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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