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Entry version 26 (08 May 2019)
Sequence version 1 (22 Jan 2014)
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Protein

Angiotensin-converting enzyme

Gene

LOTGIDRAFT_215685

Organism
Lottia gigantea (Giant owl limpet)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+UniRule annotationNote: Binds 2 Zn2+ ions per subunit.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCarboxypeptidaseUniRule annotation, Hydrolase, MetalloproteaseUniRule annotation, Protease
LigandMetal-bindingUniRule annotation, ZincUniRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Angiotensin-converting enzymeUniRule annotation (EC:3.4.-.-UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:LOTGIDRAFT_215685Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiLottia gigantea (Giant owl limpet)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri225164 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaPatellogastropodaLottioideaLottiidaeLottia
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000030746 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500471728721 – 1247Angiotensin-converting enzymeSequence analysisAdd BLAST1227

Keywords - PTMi

GlycoproteinUniRule annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase M2 family.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

KEGG Orthology (KO)

More...
KOi
K01283

Identification of Orthologs from Complete Genome Data

More...
OMAi
VTMEQLF

Database of Orthologous Groups

More...
OrthoDBi
422699at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd06461 M2_ACE, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001548 Peptidase_M2

The PANTHER Classification System

More...
PANTHERi
PTHR10514 PTHR10514, 4 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01401 Peptidase_M2, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00791 PEPDIPTASEA

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

V4AKT8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRWFHVLAFV AVIGTTKTQG SEQADAKKWL KEYNIVFGKI LNNQVRAEYT
60 70 80 90 100
YNTDITDEHQ KEQVTANVEM AAFLKEASQN ASSFNWKKFK DADIKRQMKK
110 120 130 140 150
ISDIGPSALK EHKKVEELNK ALSDMQSIYS KATVFLQNKT MNLEPGLTEL
160 170 180 190 200
FASSRDYDLL TEGWKLWRDA SGAKMKTLYQ RMVELSNEGS KENGYHDTGA
210 220 230 240 250
FWRTDYEDDN FQDTVEELLV QLKPIYTELH TYIRKKLKDL YGADKFPKTG
260 270 280 290 300
QIPAHILGNM WAQTWNNIYS LVIPYPNKPS VDVTDALKEQ NFTATRMFRT
310 320 330 340 350
AEHFFKSIGL DAMPATFWNG SMIERPSDGR DVVCYAAAWD MGDGKDFRIK
360 370 380 390 400
MCTDITMEDL ITIHHEMGHV EYFLQYKDQP SVFRDGANPG FHEAIGDTIA
410 420 430 440 450
LSVSTPKHLR KIGLLPAGEN DYEADINYLM KIALEKIAFL PFGYLIDQWR
460 470 480 490 500
WSVFSGETTP DNYNRKWWDL RCKYQGISPP VKRTEEDFDP GAKYHVAANV
510 520 530 540 550
PYIRYFISFV IQFQFHQSLC REANQTGPLH TCDIYNSLQA GTKLKNMLKL
560 570 580 590 600
GSSVQWQDAM ELITGQRKME VGPLLEYFKP LMEWLEKKNG GDGESWTDNC
610 620 630 640 650
PDPSSGGISD LEQADKFLDM YNERDSEIWF QSSELSWAYN TNLTDYNAQR
660 670 680 690 700
KTEYSLKTAN FAKEVAANAS MFDWENFHNE TRKRQFSFVA QLGTSAMKDV
710 720 730 740 750
AKLKRVSTIR SLEVENEMES VYSKGKVCLS GHTECMSLEP GLTRLLRSSS
760 770 780 790 800
NYSELTEVWE GWRDATGPKI RPLYQQFVEL SNEGYRAAGY NDTSEAWISN
810 820 830 840 850
YETENFKEDL QELLEQLKPL YQQLHTYVRG KLIEKYGKEH FPSSGHIPAH
860 870 880 890 900
LMGNMWAQTW SNIFPLLEPY PGKGDVDVTP EMLNQNYTVE RMFRTAEEFF
910 920 930 940 950
LSLGLKKMPN SFWNKSMLQK PTDGRDVVCH ASAWDFGNTK DFRIKMCTDI
960 970 980 990 1000
TMEDLITIHH EMGHIQYYLQ YKDQPTVFRG GANPGFHEAV GDVLAISVAT
1010 1020 1030 1040 1050
PRHLNKIGLL PNLKEDNETD LNFLMSLALD KIAFLPFGYL IDQWRWSVFR
1060 1070 1080 1090 1100
GQTPPDEYNR QWWDLRCKYQ GISPPTKRTE DDFDPGAKYH VPANTPYIRY
1110 1120 1130 1140 1150
FVSFVIQFQF HKALCQAANH TGPLYKCDIY QSKEAGQKLA NMLSLGTSKP
1160 1170 1180 1190 1200
WPEAMEAITG QRKMDVRPLV EFFTPLLDWL EKQNSGKKFG WSDECPTGTD
1210 1220 1230 1240
GKIRDLDAAR KWLKQYDNMA TDVRFKSVEA EYTYSTNITK YNSGLKV
Length:1,247
Mass (Da):143,807
Last modified:January 22, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF01061A78A7A92D0
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
KB201847 Genomic DNA Translation: ESO94196.1

NCBI Reference Sequences

More...
RefSeqi
XP_009055043.1, XM_009056795.1

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
LotgiT215685; LotgiP215685; LotgiG215685

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
20246586

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
lgi:LOTGIDRAFT_215685

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KB201847 Genomic DNA Translation: ESO94196.1
RefSeqiXP_009055043.1, XM_009056795.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiLotgiT215685; LotgiP215685; LotgiG215685
GeneIDi20246586
KEGGilgi:LOTGIDRAFT_215685

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
20246586

Phylogenomic databases

KOiK01283
OMAiVTMEQLF
OrthoDBi422699at2759

Family and domain databases

CDDicd06461 M2_ACE, 2 hits
InterProiView protein in InterPro
IPR001548 Peptidase_M2
PANTHERiPTHR10514 PTHR10514, 4 hits
PfamiView protein in Pfam
PF01401 Peptidase_M2, 2 hits
PRINTSiPR00791 PEPDIPTASEA

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiV4AKT8_LOTGI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: V4AKT8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: January 22, 2014
Last sequence update: January 22, 2014
Last modified: May 8, 2019
This is version 26 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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