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Protein

3-ketoacyl-CoA thiolase

Gene

fadI

Organism
Enterobacter sp. MGH 24
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed.UniRule annotationSAAS annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

Acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA.UniRule annotationSAAS annotation

Pathwayi: fatty acid beta-oxidation

This protein is involved in the pathway fatty acid beta-oxidation, which is part of Lipid metabolism.UniRule annotationSAAS annotation
View all proteins of this organism that are known to be involved in the pathway fatty acid beta-oxidation and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei110Acyl-thioester intermediateUniRule annotation1
Active sitei403Proton acceptorUniRule annotation1
Active sitei433Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferaseUniRule annotationSAAS annotation, Transferase
Biological processFatty acid metabolismUniRule annotationSAAS annotation, Lipid degradationUniRule annotationSAAS annotation, Lipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00659

Names & Taxonomyi

Protein namesi
Recommended name:
3-ketoacyl-CoA thiolaseUniRule annotation (EC:2.3.1.16UniRule annotation)
Alternative name(s):
ACSsUniRule annotation
Acetyl-CoA acyltransferaseUniRule annotation
Acyl-CoA ligaseUniRule annotation
Beta-ketothiolaseUniRule annotation
Fatty acid oxidation complex subunit betaUniRule annotation
Gene namesi
Name:fadIUniRule annotation
ORF Names:L370_04419Imported
OrganismiEnterobacter sp. MGH 24Imported
Taxonomic identifieri1329828 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEnterobacterEnterobacter cloacae complex
Proteomesi
  • UP000017624 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Heterotetramer of two alpha chains (FadJ) and two beta chains (FadI).UniRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 299Thiolase_NInterPro annotationAdd BLAST274
Domaini307 – 445Thiolase_CInterPro annotationAdd BLAST139

Sequence similaritiesi

Belongs to the thiolase family.UniRule annotationSAAS annotation

Phylogenomic databases

OrthoDBiPOG091H065K

Family and domain databases

CDDicd00751 thiolase, 1 hit
Gene3Di3.40.47.10, 1 hit
HAMAPiMF_01618 FadI, 1 hit
InterProiView protein in InterPro
IPR012806 Ac-CoA_C-AcTrfase_FadI
IPR002155 Thiolase
IPR016039 Thiolase-like
IPR020615 Thiolase_acyl_enz_int_AS
IPR020610 Thiolase_AS
IPR020617 Thiolase_C
IPR020613 Thiolase_CS
IPR020616 Thiolase_N
PANTHERiPTHR18919:SF113 PTHR18919:SF113, 1 hit
PfamiView protein in Pfam
PF02803 Thiolase_C, 1 hit
PF00108 Thiolase_N, 1 hit
PIRSFiPIRSF000429 Ac-CoA_Ac_transf, 1 hit
SUPFAMiSSF53901 SSF53901, 2 hits
TIGRFAMsiTIGR01930 AcCoA-C-Actrans, 1 hit
TIGR02446 FadI, 1 hit
PROSITEiView protein in PROSITE
PS00098 THIOLASE_1, 1 hit
PS00737 THIOLASE_2, 1 hit
PS00099 THIOLASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

V3P570-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFAKNFLQGS VMSQALPLIT RQGDRIAIVS GLRTPFARQA TAFHGIPAVD
60 70 80 90 100
LGKMVVGEML ARSEIPPEVI EQLVFGQVVQ MPEAPNIARE IVLGTGMNVH
110 120 130 140 150
TDAYSVSRAC ATSFQAVANV AESLMAGTIR AGIAGGADSS SVLPIGVSKK
160 170 180 190 200
LARILVDANK ARTTGQKLKL FSRLRLRDLM PVPPAVAEYS TGLRMGDTAE
210 220 230 240 250
QMAKTYGITR EQQDALAHRS HQLAAKAWSE GKLTDEVMTA YIPPYREPLA
260 270 280 290 300
EDNNIRGTST LADYAKLRPA FDRKHGTVTA ANSTPLTDGA AAVILMTESR
310 320 330 340 350
AKELGITPLG YLRSYAFTAI DVWQDMLLGP AWSTPLALER AGLTLADLTL
360 370 380 390 400
IDMHEAFAAQ TLANVQLLAS ERFARDVLGR AHATGEVDQS KFNVLGGSIA
410 420 430 440
YGHPFAATGA RMITQTLHEL RRRGGGFGLV TACAAGGLGA AMVLEAE
Length:447
Mass (Da):47,655
Last modified:January 22, 2014 - v1
Checksum:i64B62D4358B21D94
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AYJG01000004 Genomic DNA Translation: ESN14133.1

Genome annotation databases

EnsemblBacteriaiESN14133; ESN14133; L370_04419
PATRICifig|1329828.3.peg.4353

Similar proteinsi

Entry informationi

Entry nameiV3P570_9ENTR
AccessioniPrimary (citable) accession number: V3P570
Entry historyiIntegrated into UniProtKB/TrEMBL: January 22, 2014
Last sequence update: January 22, 2014
Last modified: July 18, 2018
This is version 35 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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