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Protein

Peptide methionine sulfoxide reductase MsrA

Gene

msrA

Organism
Escherichia coli 908573
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.UniRule annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin.UniRule annotationSAAS annotation
Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei61UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide methionine sulfoxide reductase MsrAUniRule annotation (EC:1.8.4.11UniRule annotation)
Short name:
Protein-methionine-S-oxide reductaseUniRule annotation
Alternative name(s):
Peptide-methionine (S)-S-oxide reductaseUniRule annotation
Short name:
Peptide Met(O) reductaseUniRule annotation
Gene namesi
Name:msrAUniRule annotation
ORF Names:HMPREF1611_02681Imported
OrganismiEscherichia coli 908573Imported
Taxonomic identifieri1268998 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000017634 Componenti: Unassembled WGS sequence

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini55 – 208PMSRInterPro annotationAdd BLAST154

Sequence similaritiesi

Belongs to the MsrA Met sulfoxide reductase family.UniRule annotationSAAS annotation

Family and domain databases

Gene3Di3.30.1060.10, 1 hit
HAMAPiMF_01401 MsrA, 1 hit
InterProiView protein in InterPro
IPR002569 Met_Sox_Rdtase_MsrA
IPR036509 Met_Sox_Rdtase_MsrA_sf
PfamiView protein in Pfam
PF01625 PMSR, 1 hit
SUPFAMiSSF55068 SSF55068, 1 hit
TIGRFAMsiTIGR00401 msrA, 1 hit

Sequencei

Sequence statusi: Complete.

V0YWI1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTDFRESDTM SLFDKKHLVS PADALPGRNT PMPVATLHAV NGHSMTNVPD
60 70 80 90 100
GMEIAIFAMG CFWGVERLFW QLPGVYSTAA GYTGGYTPNP TYREVCSGDT
110 120 130 140 150
GHAEAVRIVY DPSVISYEQL LQVFWENHDP AQGMRQGNDH GTQYRSAIYP
160 170 180 190 200
LTPEQDAAAR ASLERFQAAM LATDDDRRIT TEIANATPFY YAEDDHQQYL
210 220
HKNPYGYCGI GGIGVCLPPE A
Length:221
Mass (Da):24,447
Last modified:January 22, 2014 - v1
Checksum:i653ABED0C8234301
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AXTS01000086 Genomic DNA Translation: ESD85376.1

Genome annotation databases

EnsemblBacteriaiESD85376; ESD85376; HMPREF1611_02681
PATRICifig|1268998.3.peg.2514

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AXTS01000086 Genomic DNA Translation: ESD85376.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiESD85376; ESD85376; HMPREF1611_02681
PATRICifig|1268998.3.peg.2514

Family and domain databases

Gene3Di3.30.1060.10, 1 hit
HAMAPiMF_01401 MsrA, 1 hit
InterProiView protein in InterPro
IPR002569 Met_Sox_Rdtase_MsrA
IPR036509 Met_Sox_Rdtase_MsrA_sf
PfamiView protein in Pfam
PF01625 PMSR, 1 hit
SUPFAMiSSF55068 SSF55068, 1 hit
TIGRFAMsiTIGR00401 msrA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiV0YWI1_ECOLX
AccessioniPrimary (citable) accession number: V0YWI1
Entry historyiIntegrated into UniProtKB/TrEMBL: January 22, 2014
Last sequence update: January 22, 2014
Last modified: November 7, 2018
This is version 21 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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