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Protein

Crotonobetaine/carnitine--CoA ligase

Gene

caiC

Organism
Escherichia coli 908525
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the transfer of CoA to carnitine, generating the initial carnitinyl-CoA needed for the CaiB reaction cycle. Also has activity toward crotonobetaine and gamma-butyrobetaine.UniRule annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

ATP + 4-(trimethylamino)butanoate + CoA = AMP + diphosphate + gamma-butyrobetainyl-CoA.UniRule annotation
ATP + L-carnitine + CoA = AMP + diphosphate + L-carnitinyl-CoA.UniRule annotation
ATP + crotonobetaine + CoA = AMP + diphosphate + crotonobetainyl-CoA.UniRule annotation

Pathwayi: carnitine metabolism

This protein is involved in the pathway carnitine metabolism, which is part of Amine and polyamine metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway carnitine metabolism and in Amine and polyamine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationImported

Enzyme and pathway databases

UniPathwayiUPA00117

Names & Taxonomyi

Protein namesi
Recommended name:
Crotonobetaine/carnitine--CoA ligaseUniRule annotation (EC:6.2.1.48UniRule annotation)
Gene namesi
Name:caiCUniRule annotation
ORF Names:HMPREF1608_03881Imported
OrganismiEscherichia coli 908525Imported
Taxonomic identifieri1268995 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000017454 Componenti: Unassembled WGS sequence

Structurei

3D structure databases

ProteinModelPortaliV0Y2I0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 431AMP-bindingInterPro annotationAdd BLAST410
Domaini440 – 515AMP-binding_CInterPro annotationAdd BLAST76

Sequence similaritiesi

Belongs to the ATP-dependent AMP-binding enzyme family.UniRule annotation

Family and domain databases

HAMAPiMF_01524 CaiC, 1 hit
InterProiView protein in InterPro
IPR025110 AMP-bd_C
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
IPR023456 CaiC
PfamiView protein in Pfam
PF00501 AMP-binding, 1 hit
PF13193 AMP-binding_C, 1 hit
PROSITEiView protein in PROSITE
PS00455 AMP_BINDING, 1 hit

Sequencei

Sequence statusi: Complete.

V0Y2I0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRGAMDIIG GQHLRQMWDD LADVYGHKTA LICESSGGVV NRYSYLELNQ
60 70 80 90 100
EINRTANLFY TLGIRKGDKV ALHLDNCPEF IFCWFGLAKI GAIMVPINAR
110 120 130 140 150
LLREESAWIL QNSQACLLVT SAQFYPMYQQ IQQEDATQLR HICLTDVALP
160 170 180 190 200
ADDGVSSFTQ LKNQQPATLC YAPPLSTDDT AEILFTSGTT SRPKGVVITH
210 220 230 240 250
YNLRFAGYYS AWQCALRDDD VYLTVMPAFH IDCQCTAAMA AFSAGATFVL
260 270 280 290 300
VEKYSARAFW GQVQKYRATI TECIPMMIRT LMVQPPSAYD QQHRLREVMF
310 320 330 340 350
YLNLSAQEKD AFCERFGVRL LTSYGMTETI VGIIGDRPGD KRRWPSIGRA
360 370 380 390 400
GFCYEAEIRD DHNRPLPAGE IGEICIKGVP GKTIFKEYFL NPKATAKVLE
410 420 430 440 450
ADGWLHTGDT GYRDEEGFFY FVDRRCNMIK RGGENVSCVE LEDIIATHPK
460 470 480 490 500
IQDIVVVGIK DSIRDEAIKA FVVLNEGETL SEEEFFRFCE QNMAKFKVPS
510 520
YLEIRKDLPR NCSGKIIRKN LK
Length:522
Mass (Da):59,079
Last modified:January 22, 2014 - v1
Checksum:i64F356F3F5D14446
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AXTP01000280 Genomic DNA Translation: ESD66708.1

Genome annotation databases

EnsemblBacteriaiESD66708; ESD66708; HMPREF1608_03881
PATRICifig|1268995.3.peg.3410

Similar proteinsi

Entry informationi

Entry nameiV0Y2I0_ECOLX
AccessioniPrimary (citable) accession number: V0Y2I0
Entry historyiIntegrated into UniProtKB/TrEMBL: January 22, 2014
Last sequence update: January 22, 2014
Last modified: April 25, 2018
This is version 13 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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