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Protein

Argininosuccinate lyase

Gene

argH

Organism
Propionibacterium sp. KPL1847
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

2-(N(omega)-L-arginino)succinate = fumarate + L-arginine.UniRule annotationSAAS annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.UniRule annotationSAAS annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotationSAAS annotationImported
Biological processAmino-acid biosynthesis, Arginine biosynthesisUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00068; UER00114

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate lyaseUniRule annotationSAAS annotation (EC:4.3.2.1UniRule annotationSAAS annotation)
Short name:
ASALUniRule annotation
Alternative name(s):
ArginosuccinaseUniRule annotation
Gene namesi
Name:argHUniRule annotation
ORF Names:HMPREF1277_01365Imported
OrganismiPropionibacterium sp. KPL1847Imported
Taxonomic identifieri1203574 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaPropionibacterialesPropionibacteriaceaePropionibacterium
Proteomesi
  • UP000017160 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliU7JHP0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 319Lyase_1InterPro annotationAdd BLAST296
Domaini382 – 449ASL_C2InterPro annotationAdd BLAST68

Sequence similaritiesi

Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.UniRule annotationSAAS annotation

Family and domain databases

CDDicd01359 Argininosuccinate_lyase, 1 hit
Gene3Di1.10.275.10, 2 hits
HAMAPiMF_00006 Arg_succ_lyase, 1 hit
InterProiView protein in InterPro
IPR029419 Arg_succ_lyase_C
IPR009049 Argininosuccinate_lyase
IPR024083 Fumarase/histidase_N
IPR020557 Fumarate_lyase_CS
IPR000362 Fumarate_lyase_fam
IPR022761 Fumarate_lyase_N
IPR008948 L-Aspartase-like
PANTHERiPTHR43814 PTHR43814, 1 hit
PfamiView protein in Pfam
PF14698 ASL_C2, 1 hit
PF00206 Lyase_1, 1 hit
PRINTSiPR00149 FUMRATELYASE
SUPFAMiSSF48557 SSF48557, 1 hit
TIGRFAMsiTIGR00838 argH, 1 hit
PROSITEiView protein in PROSITE
PS00163 FUMARATE_LYASES, 1 hit

Sequencei

Sequence statusi: Complete.

U7JHP0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTEPYDHSQ NNAQADRPMA LWGGRFSGGP SEALAALSVS TQFDWRLARY
60 70 80 90 100
DIAGSRAHAG VLHAAGLLDD DQYEGMMKAL NALEEDVVSG RFVAQPEDED
110 120 130 140 150
VHTALERGLM ERAGKDLGGR LRAGRSRNDQ IIALLRRYLR EEARSLAGEL
160 170 180 190 200
LGLAHVLSRR AEDVGDAVIA GRTHMQHAQP VLLAHQLLAH AWPLLRDVQR
210 220 230 240 250
FRDLDARLDC SPYGSGALAG SSLGLDPEAV ARDLGFSSSV PNSIDGTAAR
260 270 280 290 300
DVVAEFAFVA AQVGVDLSRL SEEIIIWNTR EFGYVTLDDS FSTGSSIMPQ
310 320 330 340 350
KKNPDIAELA RGKAGRLIGD LAGLMASLKG LPLAYARDLQ EDKEPVFDQI
360 370 380 390 400
DQLHLLLPAI TGMVDTAVFN TDRMAEMAGQ GFSLATDVAE WLVRQGVPFR
410 420 430 440 450
VAHELSGACV REAESQNKEL ADLTDQELTA IDPRLTPQVR EVMTVQGSVR
460 470 480
SRAGRGGTAP ERVAEQITEL REAIAGLRSF GEAETR
Length:486
Mass (Da):52,710
Last modified:January 22, 2014 - v1
Checksum:iC5BC8FCC403F01FD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AXML01000002 Genomic DNA Translation: ERS33086.1

Genome annotation databases

EnsemblBacteriaiERS33086; ERS33086; HMPREF1277_01365
PATRICifig|1203574.3.peg.1418

Similar proteinsi

Entry informationi

Entry nameiU7JHP0_9ACTN
AccessioniPrimary (citable) accession number: U7JHP0
Entry historyiIntegrated into UniProtKB/TrEMBL: January 22, 2014
Last sequence update: January 22, 2014
Last modified: February 28, 2018
This is version 27 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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