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Protein

Cytochrome c oxidase subunit 1

Gene

COI

Organism
Rhynchophorus vulneratus
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.UniRule annotation

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.UniRule annotation

Pathwayi: oxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processElectron transport, Respiratory chainUniRule annotation, Transport
LigandCopperUniRule annotation, HemeUniRule annotation, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayi
UPA00705

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1UniRule annotation (EC:1.9.3.1UniRule annotation)
Gene namesi
Name:COIImported
Encoded oniMitochondrionImported
OrganismiRhynchophorus vulneratusImported
Taxonomic identifieri1486342 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaColeopteraPolyphagaCucujiformiaCurculionidaeDryophthorinaeRhynchophorus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei43 – 67HelicalSequence analysisAdd BLAST25
Transmembranei79 – 108HelicalSequence analysisAdd BLAST30
Transmembranei128 – 152HelicalSequence analysisAdd BLAST25

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membraneUniRule annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_500773143622 – 176Cytochrome c oxidase subunit 1Sequence analysisAdd BLAST155

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 176COX1InterPro annotationAdd BLAST176

Sequence similaritiesi

Belongs to the heme-copper respiratory oxidase family.UniRule annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Family and domain databases

Gene3Di1.20.210.10, 1 hit
InterProiView protein in InterPro
IPR023616 Cyt_c_oxase-like_su1_dom
IPR036927 Cyt_c_oxase-like_su1_sf
IPR000883 Cyt_C_Oxase_1
PANTHERiPTHR10422 PTHR10422, 1 hit
PfamiView protein in Pfam
PF00115 COX1, 1 hit
PRINTSiPR01165 CYCOXIDASEI
SUPFAMiSSF81442 SSF81442, 1 hit
PROSITEiView protein in PROSITE
PS50855 COX1, 1 hit

Sequencei

Sequence statusi: Fragment.

U5S7A7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
WLLPPSLTLL LMSSIVEKGA GTGWTVYPPL AGNVAHSGAS VDLAIFSLHM
60 70 80 90 100
AGISSILGAI NFISTAINMR PKGMLSDRLS LFIWAVSITA LLLLLSLPVL
110 120 130 140 150
AGAITMLLTD RNINTSFFDP AGGGDPILYQ HLFWFFGHPE VYILILPGFG
160 170
MISHIITNES GKKETFGILG MIYAMM
Length:176
Mass (Da):18,936
Last modified:January 22, 2014 - v1
Checksum:iDCA54A7B005149AD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1
Non-terminal residuei176Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KF311528 Genomic DNA Translation: AGY79534.1
KF311529 Genomic DNA Translation: AGY79535.1
KF311530 Genomic DNA Translation: AGY79536.1
KF311531 Genomic DNA Translation: AGY79537.1
KF311532 Genomic DNA Translation: AGY79538.1
KF311533 Genomic DNA Translation: AGY79539.1
KF311534 Genomic DNA Translation: AGY79540.1
KF311535 Genomic DNA Translation: AGY79541.1
KF311536 Genomic DNA Translation: AGY79542.1
KF311537 Genomic DNA Translation: AGY79543.1
KF311538 Genomic DNA Translation: AGY79544.1
KF311539 Genomic DNA Translation: AGY79545.1
KF311540 Genomic DNA Translation: AGY79546.1
KF311541 Genomic DNA Translation: AGY79547.1
KF311542 Genomic DNA Translation: AGY79548.1
KF311543 Genomic DNA Translation: AGY79549.1
KF311544 Genomic DNA Translation: AGY79550.1
KF311545 Genomic DNA Translation: AGY79551.1
KF311546 Genomic DNA Translation: AGY79552.1
KF311547 Genomic DNA Translation: AGY79553.1
KF311549 Genomic DNA Translation: AGY79555.1
KF311550 Genomic DNA Translation: AGY79556.1
KF311551 Genomic DNA Translation: AGY79557.1
KF311552 Genomic DNA Translation: AGY79558.1
KF311553 Genomic DNA Translation: AGY79559.1
KF311554 Genomic DNA Translation: AGY79560.1
KF311555 Genomic DNA Translation: AGY79561.1
KF311556 Genomic DNA Translation: AGY79562.1
KF311557 Genomic DNA Translation: AGY79563.1
KF311558 Genomic DNA Translation: AGY79564.1
KF311559 Genomic DNA Translation: AGY79565.1
KF311560 Genomic DNA Translation: AGY79566.1
KF311561 Genomic DNA Translation: AGY79567.1
KF311562 Genomic DNA Translation: AGY79568.1
KF311565 Genomic DNA Translation: AGY79571.1
KF311566 Genomic DNA Translation: AGY79572.1
KF311567 Genomic DNA Translation: AGY79573.1
KF311568 Genomic DNA Translation: AGY79574.1
KF311569 Genomic DNA Translation: AGY79575.1
KF311570 Genomic DNA Translation: AGY79576.1
KF311571 Genomic DNA Translation: AGY79577.1
KF311572 Genomic DNA Translation: AGY79578.1
KF311573 Genomic DNA Translation: AGY79579.1
KF311574 Genomic DNA Translation: AGY79580.1
KF311575 Genomic DNA Translation: AGY79581.1
KF311579 Genomic DNA Translation: AGY79585.1
KF311580 Genomic DNA Translation: AGY79586.1
KF311581 Genomic DNA Translation: AGY79587.1
KF311582 Genomic DNA Translation: AGY79588.1
KF311583 Genomic DNA Translation: AGY79589.1
KF311584 Genomic DNA Translation: AGY79590.1
KF311585 Genomic DNA Translation: AGY79591.1
KF311586 Genomic DNA Translation: AGY79592.1
KF311587 Genomic DNA Translation: AGY79593.1
KF311588 Genomic DNA Translation: AGY79594.1
KF311589 Genomic DNA Translation: AGY79595.1
KF311590 Genomic DNA Translation: AGY79596.1
KF311591 Genomic DNA Translation: AGY79597.1
KF311593 Genomic DNA Translation: AGY79599.1
KF311594 Genomic DNA Translation: AGY79600.1
KF311595 Genomic DNA Translation: AGY79601.1
KF311596 Genomic DNA Translation: AGY79602.1
KF311597 Genomic DNA Translation: AGY79603.1
KF311598 Genomic DNA Translation: AGY79604.1
KF311599 Genomic DNA Translation: AGY79605.1
KF311600 Genomic DNA Translation: AGY79606.1
KF311601 Genomic DNA Translation: AGY79607.1
KF311602 Genomic DNA Translation: AGY79608.1
KF311603 Genomic DNA Translation: AGY79609.1
KF311604 Genomic DNA Translation: AGY79610.1
KF311605 Genomic DNA Translation: AGY79611.1
KF311606 Genomic DNA Translation: AGY79612.1
KF311607 Genomic DNA Translation: AGY79613.1
KF311608 Genomic DNA Translation: AGY79614.1
KF311609 Genomic DNA Translation: AGY79615.1
KF311610 Genomic DNA Translation: AGY79616.1
KF311611 Genomic DNA Translation: AGY79617.1
KF311612 Genomic DNA Translation: AGY79618.1
KF311613 Genomic DNA Translation: AGY79619.1
KF311614 Genomic DNA Translation: AGY79620.1
KF311615 Genomic DNA Translation: AGY79621.1
KF311616 Genomic DNA Translation: AGY79622.1
KF311617 Genomic DNA Translation: AGY79623.1
KF311618 Genomic DNA Translation: AGY79624.1
KF311619 Genomic DNA Translation: AGY79625.1
KF311620 Genomic DNA Translation: AGY79626.1
KF311621 Genomic DNA Translation: AGY79627.1
KF311622 Genomic DNA Translation: AGY79628.1
KF311623 Genomic DNA Translation: AGY79629.1
KF311624 Genomic DNA Translation: AGY79630.1
KF311625 Genomic DNA Translation: AGY79631.1
KF311626 Genomic DNA Translation: AGY79632.1
KF311627 Genomic DNA Translation: AGY79633.1
KF311628 Genomic DNA Translation: AGY79634.1
KF311629 Genomic DNA Translation: AGY79635.1
KF311630 Genomic DNA Translation: AGY79636.1
KF311631 Genomic DNA Translation: AGY79637.1
KF311632 Genomic DNA Translation: AGY79638.1
KF311633 Genomic DNA Translation: AGY79639.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KF311528 Genomic DNA Translation: AGY79534.1
KF311529 Genomic DNA Translation: AGY79535.1
KF311530 Genomic DNA Translation: AGY79536.1
KF311531 Genomic DNA Translation: AGY79537.1
KF311532 Genomic DNA Translation: AGY79538.1
KF311533 Genomic DNA Translation: AGY79539.1
KF311534 Genomic DNA Translation: AGY79540.1
KF311535 Genomic DNA Translation: AGY79541.1
KF311536 Genomic DNA Translation: AGY79542.1
KF311537 Genomic DNA Translation: AGY79543.1
KF311538 Genomic DNA Translation: AGY79544.1
KF311539 Genomic DNA Translation: AGY79545.1
KF311540 Genomic DNA Translation: AGY79546.1
KF311541 Genomic DNA Translation: AGY79547.1
KF311542 Genomic DNA Translation: AGY79548.1
KF311543 Genomic DNA Translation: AGY79549.1
KF311544 Genomic DNA Translation: AGY79550.1
KF311545 Genomic DNA Translation: AGY79551.1
KF311546 Genomic DNA Translation: AGY79552.1
KF311547 Genomic DNA Translation: AGY79553.1
KF311549 Genomic DNA Translation: AGY79555.1
KF311550 Genomic DNA Translation: AGY79556.1
KF311551 Genomic DNA Translation: AGY79557.1
KF311552 Genomic DNA Translation: AGY79558.1
KF311553 Genomic DNA Translation: AGY79559.1
KF311554 Genomic DNA Translation: AGY79560.1
KF311555 Genomic DNA Translation: AGY79561.1
KF311556 Genomic DNA Translation: AGY79562.1
KF311557 Genomic DNA Translation: AGY79563.1
KF311558 Genomic DNA Translation: AGY79564.1
KF311559 Genomic DNA Translation: AGY79565.1
KF311560 Genomic DNA Translation: AGY79566.1
KF311561 Genomic DNA Translation: AGY79567.1
KF311562 Genomic DNA Translation: AGY79568.1
KF311565 Genomic DNA Translation: AGY79571.1
KF311566 Genomic DNA Translation: AGY79572.1
KF311567 Genomic DNA Translation: AGY79573.1
KF311568 Genomic DNA Translation: AGY79574.1
KF311569 Genomic DNA Translation: AGY79575.1
KF311570 Genomic DNA Translation: AGY79576.1
KF311571 Genomic DNA Translation: AGY79577.1
KF311572 Genomic DNA Translation: AGY79578.1
KF311573 Genomic DNA Translation: AGY79579.1
KF311574 Genomic DNA Translation: AGY79580.1
KF311575 Genomic DNA Translation: AGY79581.1
KF311579 Genomic DNA Translation: AGY79585.1
KF311580 Genomic DNA Translation: AGY79586.1
KF311581 Genomic DNA Translation: AGY79587.1
KF311582 Genomic DNA Translation: AGY79588.1
KF311583 Genomic DNA Translation: AGY79589.1
KF311584 Genomic DNA Translation: AGY79590.1
KF311585 Genomic DNA Translation: AGY79591.1
KF311586 Genomic DNA Translation: AGY79592.1
KF311587 Genomic DNA Translation: AGY79593.1
KF311588 Genomic DNA Translation: AGY79594.1
KF311589 Genomic DNA Translation: AGY79595.1
KF311590 Genomic DNA Translation: AGY79596.1
KF311591 Genomic DNA Translation: AGY79597.1
KF311593 Genomic DNA Translation: AGY79599.1
KF311594 Genomic DNA Translation: AGY79600.1
KF311595 Genomic DNA Translation: AGY79601.1
KF311596 Genomic DNA Translation: AGY79602.1
KF311597 Genomic DNA Translation: AGY79603.1
KF311598 Genomic DNA Translation: AGY79604.1
KF311599 Genomic DNA Translation: AGY79605.1
KF311600 Genomic DNA Translation: AGY79606.1
KF311601 Genomic DNA Translation: AGY79607.1
KF311602 Genomic DNA Translation: AGY79608.1
KF311603 Genomic DNA Translation: AGY79609.1
KF311604 Genomic DNA Translation: AGY79610.1
KF311605 Genomic DNA Translation: AGY79611.1
KF311606 Genomic DNA Translation: AGY79612.1
KF311607 Genomic DNA Translation: AGY79613.1
KF311608 Genomic DNA Translation: AGY79614.1
KF311609 Genomic DNA Translation: AGY79615.1
KF311610 Genomic DNA Translation: AGY79616.1
KF311611 Genomic DNA Translation: AGY79617.1
KF311612 Genomic DNA Translation: AGY79618.1
KF311613 Genomic DNA Translation: AGY79619.1
KF311614 Genomic DNA Translation: AGY79620.1
KF311615 Genomic DNA Translation: AGY79621.1
KF311616 Genomic DNA Translation: AGY79622.1
KF311617 Genomic DNA Translation: AGY79623.1
KF311618 Genomic DNA Translation: AGY79624.1
KF311619 Genomic DNA Translation: AGY79625.1
KF311620 Genomic DNA Translation: AGY79626.1
KF311621 Genomic DNA Translation: AGY79627.1
KF311622 Genomic DNA Translation: AGY79628.1
KF311623 Genomic DNA Translation: AGY79629.1
KF311624 Genomic DNA Translation: AGY79630.1
KF311625 Genomic DNA Translation: AGY79631.1
KF311626 Genomic DNA Translation: AGY79632.1
KF311627 Genomic DNA Translation: AGY79633.1
KF311628 Genomic DNA Translation: AGY79634.1
KF311629 Genomic DNA Translation: AGY79635.1
KF311630 Genomic DNA Translation: AGY79636.1
KF311631 Genomic DNA Translation: AGY79637.1
KF311632 Genomic DNA Translation: AGY79638.1
KF311633 Genomic DNA Translation: AGY79639.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayi
UPA00705

Family and domain databases

Gene3Di1.20.210.10, 1 hit
InterProiView protein in InterPro
IPR023616 Cyt_c_oxase-like_su1_dom
IPR036927 Cyt_c_oxase-like_su1_sf
IPR000883 Cyt_C_Oxase_1
PANTHERiPTHR10422 PTHR10422, 1 hit
PfamiView protein in Pfam
PF00115 COX1, 1 hit
PRINTSiPR01165 CYCOXIDASEI
SUPFAMiSSF81442 SSF81442, 1 hit
PROSITEiView protein in PROSITE
PS50855 COX1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiU5S7A7_9CUCU
AccessioniPrimary (citable) accession number: U5S7A7
Entry historyiIntegrated into UniProtKB/TrEMBL: January 22, 2014
Last sequence update: January 22, 2014
Last modified: May 23, 2018
This is version 22 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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