UniProtKB - U5KJT7 (CAMP_BOTLT)
Protein
Cathelicidin-related peptide lutzicidin
Gene
N/A
Organism
Bothrops lutzi (Sertao lancehead) (Bothrops iglesiasi)
Status
Functioni
Potent antimicrobial peptide against Gram-negative and Gram-positive bacteria. Adopts an amphipathic alpha helical conformation, that may allow to partition into the target membrane. Low hemolytic activities have been observed on mammalian cells.By similarity
Miscellaneous
The putative mature sequence has been predicted by AMPA, a predictive algorithm for identification of peptide stretches with antimicrobial properties.1 Publication
GO - Biological processi
- defense response to bacterium Source: UniProtKB-KW
Keywordsi
Molecular function | Antibiotic, Antimicrobial |
Names & Taxonomyi
Protein namesi | Recommended name: Cathelicidin-related peptide lutzicidinAlternative name(s): Cathelicidin-related antimicrobial peptide |
Organismi | Bothrops lutzi (Sertao lancehead) (Bothrops iglesiasi) |
Taxonomic identifieri | 1368281 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Serpentes › Colubroidea › Viperidae › Crotalinae › Bothrops › |
Subcellular locationi
Extracellular region or secreted
- Secreted By similarity
Other locations
- Target cell membrane By similarity
Note: Forms a helical membrane channel in the prey.By similarity
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Other locations
- membrane Source: UniProtKB-KW
- other organism cell membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Membrane, Secreted, Target cell membrane, Target membranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000432324 | 1 – 189 | Cathelicidin-related peptide lutzicidinAdd BLAST | 189 | |
Signal peptidei | 1 – 22 | Sequence analysisAdd BLAST | 22 | |
PropeptideiPRO_0000432325 | 23 – 155 | Sequence analysisAdd BLAST | 133 | |
PeptideiPRO_0000432326 | 156 – 189 | Cathelicidin-related peptide lutzicidinAdd BLAST | 34 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 79 ↔ 90 | By similarity | ||
Disulfide bondi | 101 ↔ 118 | By similarity |
Keywords - PTMi
Cleavage on pair of basic residues, Disulfide bondExpressioni
Tissue specificityi
Expressed by the venom gland.1 Publication
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 82 – 148 | Glu-richPROSITE-ProRule annotationAdd BLAST | 67 |
Sequence similaritiesi
Belongs to the cathelicidin family.Curated
Keywords - Domaini
SignalFamily and domain databases
InterProi | View protein in InterPro IPR001894 Cathelicidin |
PANTHERi | PTHR10206 PTHR10206, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
U5KJT7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQGFFWKTLL VVALCGTSSS LAHRPLSYGE ALELALSVYN SKAGEESLFR
60 70 80 90 100
LLEAVPQPEW DPLSEGSQQL NFTIKETVCQ VEEERPLEEC GFQEDGVVLE
110 120 130 140 150
CTGYYFFGET PPVVVLTCVP VGGVEEEEED EEEQKAEVEK DEEKEDEEKD
160 170 180
RPKRVKRFKK FFKKLKNNVK KRVKKFFRKP RVIGVTIPF
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | JX948112 mRNA Translation: AGS36141.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | JX948112 mRNA Translation: AGS36141.1 |
3D structure databases
SMRi | U5KJT7 |
ModBasei | Search... |
MobiDBi | Search... |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Family and domain databases
InterProi | View protein in InterPro IPR001894 Cathelicidin |
PANTHERi | PTHR10206 PTHR10206, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | CAMP_BOTLT | |
Accessioni | U5KJT7Primary (citable) accession number: U5KJT7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 4, 2015 |
Last sequence update: | January 22, 2014 | |
Last modified: | April 12, 2017 | |
This is version 12 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |