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Protein

Cathelicidin-related peptide crotalicidin

Gene
N/A
Organism
Crotalus durissus terrificus (South American rattlesnake)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Potent antimicrobial peptide against Gram-negative (MIC=0.25 µg/mL against E.coli ATCC 25922, MIC=1 µg/mL against P.aeruginosa) and Gram-positive bacteria (MIC=32 µg/mL against E.faecalis, MIC=32 µg/mL against S.aureus) (PubMed:25100358). Adopts an amphipathic alpha helical conformation, that may allow to partition into the target membrane (By similarity). Low hemolytic activities have been observed on mammalian cells (PubMed:25100358).By similarity1 Publication

Miscellaneous

The putative mature sequence has been predicted by AMPA, a predictive algorithm for identification of peptide stretches with antimicrobial properties.1 Publication

GO - Biological processi

Keywordsi

Molecular functionAntibiotic, Antimicrobial

Names & Taxonomyi

Protein namesi
Recommended name:
Cathelicidin-related peptide crotalicidin
Alternative name(s):
Cathelicidin-related antimicrobial peptide
OrganismiCrotalus durissus terrificus (South American rattlesnake)
Taxonomic identifieri8732 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaViperidaeCrotalinaeCrotalus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Secreted, Target cell membrane, Target membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
PropeptideiPRO_000043213523 – 164Sequence analysisAdd BLAST142
PeptideiPRO_0000432136161 – 194Cathelicidin-related peptide crotalicidinAdd BLAST34

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi79 ↔ 90By similarity
Disulfide bondi101 ↔ 118By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.1 Publication

Structurei

Secondary structure

1194
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SMRiU5KJM4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi82 – 153Glu-richPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Belongs to the cathelicidin family.Curated

Keywords - Domaini

Signal

Family and domain databases

InterProiView protein in InterPro
IPR001894 Cathelicidin
PANTHERiPTHR10206 PTHR10206, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

U5KJM4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQGFFWKTWL VLAVCGTPAS LAHRPLSYGE ALELAVSVYN GKAGEASLYR
60 70 80 90 100
LLEAVPQPEW DPSSEGSQQL NFTLKETACQ VEEERSLEEC GFQEDGVVLE
110 120 130 140 150
CTGYYFFGET PPVVVLSCVP VGGVEEEEEE EEEEQKAEAE NDEEVEKEKG
160 170 180 190
DEEKDQPKRV KRFKKFFKKV KKSVKKRLKK IFKKPMVIGV TIPF
Length:194
Mass (Da):22,006
Last modified:January 22, 2014 - v1
Checksum:iE2BBE720F1C3960C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JX948107 mRNA Translation: AGS36138.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JX948107 mRNA Translation: AGS36138.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2MWTNMR-A161-194[»]
SMRiU5KJM4
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiView protein in InterPro
IPR001894 Cathelicidin
PANTHERiPTHR10206 PTHR10206, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCAMP_CRODU
AccessioniPrimary (citable) accession number: U5KJM4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 4, 2015
Last sequence update: January 22, 2014
Last modified: November 2, 2016
This is version 13 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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