Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Maternal embryonic leucine zipper kinase

Gene

pig-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Serine/threonine-protein kinase involved in cell autonomous neuroblast asymmetric divisions that generate one precursor cell and one apoptotic cell by controlling spindle positioning, myosin distribution and the segregation of cell fate determinants (PubMed:16774992, PubMed:20929735, PubMed:23946438, PubMed:23267054, PubMed:23851392). Promotes cell shedding during embryogenesis, probably through the endocytosis-mediated removal of cell adhesion molecules such as hmp-1 from the cell surface (PubMed:22801495). May act downstream of par-4/strd-1/mop-25 to regulate cell shedding (PubMed:22801495).6 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei40ATPPROSITE-ProRule annotation1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei132Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi17 – 25ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • non-membrane spanning protein tyrosine kinase activity Source: GO_Central
  • protein serine/threonine kinase activity Source: WormBase

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Kinase, Serine/threonine-protein kinase, Transferase
Biological processApoptosis, Neurogenesis
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Maternal embryonic leucine zipper kinaseBy similarity (EC:2.7.11.1By similarity)
Short name:
MELKBy similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:pig-1Imported
ORF Names:W03G1.6Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IV

Organism-specific databases

WormBase

More...
WormBasei
W03G1.6a ; CE40473 ; WBGene00021012 ; pig-1
W03G1.6b ; CE40474 ; WBGene00021012 ; pig-1
W03G1.6c ; CE48676 ; WBGene00021012 ; pig-1
W03G1.6d ; CE49097 ; WBGene00021012 ; pig-1
W03G1.6e ; CE48957 ; WBGene00021012 ; pig-1
W03G1.6f ; CE48801 ; WBGene00021012 ; pig-1
W03G1.6g ; CE48617 ; WBGene00021012 ; pig-1
W03G1.6h ; CE49061 ; WBGene00021012 ; pig-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

During neuroblast differentiation, mutants produce an additional precursor cell for the HSN/PHB, I2, M4 and PLM/ALN and Q.a and Q.p lineages. The nucleus size of the 2 Q.p daughter cells is similar (PubMed:16774992). Symmetrical distribution of myosin II during QR.a cell division (PubMed:20929735). Double knockouts of pig-1 and ced-3 have impaired cell shedding during embryogenesis which results in the generation of an ectopic excretory cell and an ERM-like neuron. In addition, mutants show a delay in clearance after engulfment of cell corpses which is associated with the abnormal expression of cell adhesion molecules (PubMed:22801495).3 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi169T → A: May be inactive. Prevents cell shedding during embryogenesis. Additional production of PVM neuron. 2 Publications1
Mutagenesisi169T → D: May be constitutively active. Promotes cell shedding during embryogenesis. In some mutants, production of an additional PVM neuron. 2 Publications1
Mutagenesisi172G → E in n4780; production of an additional M4 motor neuron. 1 Publication1
Mutagenesisi172G → R in gm300; production of an additional HSN/PHB precursor cell. 1 Publication1
Mutagenesisi198G → D in gm301; production of an additional HSN/PHB precursor cell and an additional PVM precursor cell. 2 Publications1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004323871 – 706Maternal embryonic leucine zipper kinaseAdd BLAST706

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

May be phosphorylated at Thr-169 by par-4 and/or autophosphorylated which likely results in its activation (PubMed:22801495). Phosphorylation is not required for co-localization with the centrosome (PubMed:23267054).2 Publications

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
U4PR86

PeptideAtlas

More...
PeptideAtlasi
U4PR86

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Ubiquitously expressed in early embryo with a more restricted expression in later embryonic stages and in young larvae. Expressed in dividing cells including ventral nerve cord neuroblasts, vulval precursors, hypodermal seam cells and in the Q lineage. No expression in adults.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00021012 Expressed in 5 organ(s), highest expression level in multi-cellular organism

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
U4PR86, 1 interactor

STRING: functional protein association networks

More...
STRINGi
6239.W03G1.6a

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
U4PR86

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
U4PR86

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini11 – 265Protein kinasePROSITE-ProRule annotationAdd BLAST255
Domaini656 – 705KA1PROSITE-ProRule annotationAdd BLAST50

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The KA1 domain is required for the control of asymmetric neuroblast division.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0583 Eukaryota
COG0515 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154889

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000233023

KEGG Orthology (KO)

More...
KOi
K08799

Identification of Orthologs from Complete Genome Data

More...
OMAi
SHQHVCR

Database of Orthologous Groups

More...
OrthoDBi
EOG091G05V9

Family and domain databases

Conserved Domains Database

More...
CDDi
cd14078 STKc_MELK, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR028375 KA1/Ssp2_C
IPR001772 KA1_dom
IPR011009 Kinase-like_dom_sf
IPR034673 MELK
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02149 KA1, 1 hit
PF00069 Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00220 S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103243 SSF103243, 1 hit
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50032 KA1, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (8)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 8 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform cImported (identifier: U4PR86-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSKYEVLQGF YAVHDELGSG GFGKVRLATH LLTNQKVAIK IIDKKQLGHD
60 70 80 90 100
LPRVQTEMDA LRNLSHQNIC RLYHYIETED KFFIVMEYCS GGEMFDYIVR
110 120 130 140 150
KERLEESEAR HFFRQLVSAI AFVHSQGYAH RDLKPENLLL TEDLHLKLID
160 170 180 190 200
FGLCAKTEKG RIDKHNLDTC CGSPAYAAPE LIQGLQYKGN EADVWSMGIL
210 220 230 240 250
LYTLLVGALP FEDDNMQIMY KKIQSGCFYE PEFLSPLSKQ LLRAMLQVVP
260 270 280 290 300
ERRISVKKLL EHDWLNHKYT QPVKWNTIYD KNFIDRDVAR VMSKYYGFES
310 320 330 340 350
TDKMIEKIKE WNFDYMTSTY YALLHRKRNG MEIILPMVRN STNTAPPNVQ
360 370 380 390 400
NILCSPTIHA SLENNLDKSG LEDDDSDPSS ISSSSDISAR LKKNCVVSDE
410 420 430 440 450
SSSSRFVKPM SPAAEKDKKM SYVNAMLTMP SQFTGRSPLR IPESPMSVRS
460 470 480 490 500
SDSASLGSAA TPSRGGVKDN DKENASTGKN YRMGASTCKS RGPLKITGVE
510 520 530 540 550
EGTMKSVYTT PNTRPTLRGL FSPGNAEHKK RQRARSSDRA SIGMPPGSPV
560 570 580 590 600
SIGSAHSANN ELLADGRTPR SRIKTNRLPQ RVFTSLERKK EKLITLLTPR
610 620 630 640 650
KMQRDSPQVL KDVKNMVNVS MTASQDPEEV RNLLKKVFDD ERMRYELNGW
660 670 680 690 700
KFLATQETVH GWMTVELEIV RLQMFDKVGI RRKRLKGDAF MYKKVCEKIL

QMAKIE
Note: No experimental confirmation available.Curated
Length:706
Mass (Da):80,340
Last modified:December 11, 2013 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7A6A330E2F5C4E2A
GO
Isoform aImported (identifier: U4PR86-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     561-563: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:703
Mass (Da):79,985
Checksum:iD720707B90C1C046
GO
Isoform bImported (identifier: U4PR86-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     561-563: Missing.
     679-706: GIRRKRLKGDAFMYKKVCEKILQMAKIE → RNLRRFFCCVNINIPSRKPTYIEL

Note: No experimental confirmation available.Curated
Show »
Length:699
Mass (Da):79,584
Checksum:i6E5A53D6688861FA
GO
Isoform dImported (identifier: U4PR86-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     679-706: GIRRKRLKGDAFMYKKVCEKILQMAKIE → RNLRRFFCCVNINIPSRKPTYIEL

Note: No experimental confirmation available.Curated
Show »
Length:702
Mass (Da):79,940
Checksum:iE1C7DDBABB7A5B03
GO
Isoform eImported (identifier: U4PR86-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-244: Missing.
     561-563: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:459
Mass (Da):52,003
Checksum:iD1471995CE4706FB
GO
Isoform fImported (identifier: U4PR86-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-244: Missing.
     561-563: Missing.
     679-706: GIRRKRLKGDAFMYKKVCEKILQMAKIE → RNLRRFFCCVNINIPSRKPTYIEL

Note: No experimental confirmation available.Curated
Show »
Length:455
Mass (Da):51,602
Checksum:iB0DC956B6C561F62
GO
Isoform gImported (identifier: U4PR86-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-244: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:462
Mass (Da):52,358
Checksum:iA77B6CF84835A074
GO
Isoform hImported (identifier: U4PR86-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-244: Missing.
     679-706: GIRRKRLKGDAFMYKKVCEKILQMAKIE → RNLRRFFCCVNINIPSRKPTYIEL

Note: No experimental confirmation available.Curated
Show »
Length:458
Mass (Da):51,957
Checksum:i46AE33E43DBCE607
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0575061 – 244Missing in isoform e, isoform f, isoform g and isoform h. CuratedAdd BLAST244
Alternative sequenceiVSP_057507561 – 563Missing in isoform a, isoform b, isoform e and isoform f. Curated3
Alternative sequenceiVSP_057508679 – 706GIRRK…MAKIE → RNLRRFFCCVNINIPSRKPT YIEL in isoform b, isoform d, isoform f and isoform h. CuratedAdd BLAST28

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
FO081096 Genomic DNA Translation: CCD69087.1
FO081096 Genomic DNA Translation: CCD69088.1
FO081096 Genomic DNA Translation: CDH93078.1
FO081096 Genomic DNA Translation: CDH93079.1
FO081096 Genomic DNA Translation: CDH93080.1
FO081096 Genomic DNA Translation: CDH93081.1
FO081096 Genomic DNA Translation: CDH93082.1
FO081096 Genomic DNA Translation: CDH93083.1

NCBI Reference Sequences

More...
RefSeqi
NP_001023420.2, NM_001028249.3 [U4PR86-2]
NP_001023421.2, NM_001028250.2 [U4PR86-3]
NP_001294353.1, NM_001307424.1 [U4PR86-1]
NP_001294354.1, NM_001307425.1 [U4PR86-4]
NP_001294355.1, NM_001307426.1 [U4PR86-5]
NP_001294356.1, NM_001307427.1 [U4PR86-6]
NP_001294357.1, NM_001307428.1 [U4PR86-7]
NP_001294358.1, NM_001307429.1 [U4PR86-8]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Cel.5632

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
W03G1.6a; W03G1.6a; WBGene00021012 [U4PR86-2]
W03G1.6b; W03G1.6b; WBGene00021012 [U4PR86-3]
W03G1.6c; W03G1.6c; WBGene00021012 [U4PR86-1]
W03G1.6d; W03G1.6d; WBGene00021012 [U4PR86-4]
W03G1.6e; W03G1.6e; WBGene00021012 [U4PR86-5]
W03G1.6f; W03G1.6f; WBGene00021012 [U4PR86-6]
W03G1.6g; W03G1.6g; WBGene00021012 [U4PR86-7]
W03G1.6h; W03G1.6h; WBGene00021012 [U4PR86-8]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
176877

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_W03G1.6

UCSC genome browser

More...
UCSCi
W03G1.6a c. elegans

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081096 Genomic DNA Translation: CCD69087.1
FO081096 Genomic DNA Translation: CCD69088.1
FO081096 Genomic DNA Translation: CDH93078.1
FO081096 Genomic DNA Translation: CDH93079.1
FO081096 Genomic DNA Translation: CDH93080.1
FO081096 Genomic DNA Translation: CDH93081.1
FO081096 Genomic DNA Translation: CDH93082.1
FO081096 Genomic DNA Translation: CDH93083.1
RefSeqiNP_001023420.2, NM_001028249.3 [U4PR86-2]
NP_001023421.2, NM_001028250.2 [U4PR86-3]
NP_001294353.1, NM_001307424.1 [U4PR86-1]
NP_001294354.1, NM_001307425.1 [U4PR86-4]
NP_001294355.1, NM_001307426.1 [U4PR86-5]
NP_001294356.1, NM_001307427.1 [U4PR86-6]
NP_001294357.1, NM_001307428.1 [U4PR86-7]
NP_001294358.1, NM_001307429.1 [U4PR86-8]
UniGeneiCel.5632

3D structure databases

ProteinModelPortaliU4PR86
SMRiU4PR86
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiU4PR86, 1 interactor
STRINGi6239.W03G1.6a

Proteomic databases

PaxDbiU4PR86
PeptideAtlasiU4PR86

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiW03G1.6a; W03G1.6a; WBGene00021012 [U4PR86-2]
W03G1.6b; W03G1.6b; WBGene00021012 [U4PR86-3]
W03G1.6c; W03G1.6c; WBGene00021012 [U4PR86-1]
W03G1.6d; W03G1.6d; WBGene00021012 [U4PR86-4]
W03G1.6e; W03G1.6e; WBGene00021012 [U4PR86-5]
W03G1.6f; W03G1.6f; WBGene00021012 [U4PR86-6]
W03G1.6g; W03G1.6g; WBGene00021012 [U4PR86-7]
W03G1.6h; W03G1.6h; WBGene00021012 [U4PR86-8]
GeneIDi176877
KEGGicel:CELE_W03G1.6
UCSCiW03G1.6a c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
176877
WormBaseiW03G1.6a ; CE40473 ; WBGene00021012 ; pig-1
W03G1.6b ; CE40474 ; WBGene00021012 ; pig-1
W03G1.6c ; CE48676 ; WBGene00021012 ; pig-1
W03G1.6d ; CE49097 ; WBGene00021012 ; pig-1
W03G1.6e ; CE48957 ; WBGene00021012 ; pig-1
W03G1.6f ; CE48801 ; WBGene00021012 ; pig-1
W03G1.6g ; CE48617 ; WBGene00021012 ; pig-1
W03G1.6h ; CE49061 ; WBGene00021012 ; pig-1

Phylogenomic databases

eggNOGiKOG0583 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00940000154889
HOGENOMiHOG000233023
KOiK08799
OMAiSHQHVCR
OrthoDBiEOG091G05V9

Miscellaneous databases

Protein Ontology

More...
PROi
PR:U4PR86

Gene expression databases

BgeeiWBGene00021012 Expressed in 5 organ(s), highest expression level in multi-cellular organism

Family and domain databases

CDDicd14078 STKc_MELK, 1 hit
InterProiView protein in InterPro
IPR028375 KA1/Ssp2_C
IPR001772 KA1_dom
IPR011009 Kinase-like_dom_sf
IPR034673 MELK
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF02149 KA1, 1 hit
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF103243 SSF103243, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50032 KA1, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMELK_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: U4PR86
Secondary accession number(s): A7WK47
, A7WK48, U4PB44, U4PBH9, U4PED2, U4PLZ7, U4PR90
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 4, 2015
Last sequence update: December 11, 2013
Last modified: December 5, 2018
This is version 44 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again