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Protein

Orotidine 5'-phosphate decarboxylase

Gene

pyrF

Organism
Aeropyrum camini SY1 = JCM 12091
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).UniRule annotation

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

Pathwayi: UMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes UMP from orotate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Orotate phosphoribosyltransferase (pyrE)
  2. Orotidine 5'-phosphate decarboxylase (pyrF)
This subpathway is part of the pathway UMP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UMP from orotate, the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei18SubstrateUniRule annotation1
Binding sitei43SubstrateUniRule annotation1
Active sitei75Proton donorUniRule annotation1
Binding sitei130SubstrateUniRule annotation1
Binding sitei206Substrate; via amide nitrogenUniRule annotation1
Binding sitei207SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylaseUniRule annotation, Lyase
Biological processPyrimidine biosynthesisUniRule annotation

Enzyme and pathway databases

UniPathwayi
UPA00070;UER00120

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylaseUniRule annotation (EC:4.1.1.23UniRule annotation)
Alternative name(s):
OMP decarboxylaseUniRule annotation
Short name:
OMPDCaseUniRule annotation
Short name:
OMPdecaseUniRule annotation
Gene namesi
Name:pyrFUniRule annotationImported
ORF Names:ACAM_1476Imported
OrganismiAeropyrum camini SY1 = JCM 12091Imported
Taxonomic identifieri1198449 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeAeropyrum
Proteomesi
  • UP000016887 Componenti: Chromosome

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliU3TFY0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 222OMPdecaseInterPro annotationAdd BLAST211

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni73 – 82Substrate bindingUniRule annotation10
Regioni182 – 192Substrate bindingUniRule annotationAdd BLAST11

Sequence similaritiesi

Belongs to the OMP decarboxylase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

KOiK01591
OrthoDBiPOG093Z0B4G

Family and domain databases

Gene3Di3.20.20.70, 1 hit
HAMAPiMF_01200_A OMPdecase_type1_A, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR014732 OMPdecase
IPR001754 OMPdeCOase_dom
IPR011060 RibuloseP-bd_barrel
PANTHERiPTHR32119:SF2 PTHR32119:SF2, 1 hit
PfamiView protein in Pfam
PF00215 OMPdecase, 1 hit
SMARTiView protein in SMART
SM00934 OMPdecase, 1 hit
SUPFAMiSSF51366 SSF51366, 1 hit

Sequencei

Sequence statusi: Complete.

U3TFY0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSQGSAGLAV KRVIVALDPA VEGDVEKLLG IARLACREGA GIKVGLPMLA
60 70 80 90 100
LGGSEAVSEA ARLCSGGGLR VLDLKLADIG YVMRLAVESL ARGFDAAIAH
110 120 130 140 150
AFIGSEGALE ELKGALEGMG VRLVLVLSMS HQGSAEVIDP CLDRLISVAT
160 170 180 190 200
RVRPWGVVAP ATRPGVIARV RSAMPRTVIM SPGVGAQGGR PGDAICLGGA
210 220 230
DYEIVGRVVT RSPDPVSALR SVAGSIAERC PERLLPAST
Length:239
Mass (Da):24,450
Last modified:December 11, 2013 - v1
Checksum:i665A6BE8C6DE3991
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP012489 Genomic DNA Translation: BAN90945.1

Genome annotation databases

EnsemblBacteriaiBAN90945; BAN90945; ACAM_1476
KEGGiacj:ACAM_1476

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP012489 Genomic DNA Translation: BAN90945.1

3D structure databases

ProteinModelPortaliU3TFY0
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAN90945; BAN90945; ACAM_1476
KEGGiacj:ACAM_1476

Phylogenomic databases

KOiK01591
OrthoDBiPOG093Z0B4G

Enzyme and pathway databases

UniPathwayi
UPA00070;UER00120

Family and domain databases

Gene3Di3.20.20.70, 1 hit
HAMAPiMF_01200_A OMPdecase_type1_A, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR014732 OMPdecase
IPR001754 OMPdeCOase_dom
IPR011060 RibuloseP-bd_barrel
PANTHERiPTHR32119:SF2 PTHR32119:SF2, 1 hit
PfamiView protein in Pfam
PF00215 OMPdecase, 1 hit
SMARTiView protein in SMART
SM00934 OMPdecase, 1 hit
SUPFAMiSSF51366 SSF51366, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiU3TFY0_9CREN
AccessioniPrimary (citable) accession number: U3TFY0
Entry historyiIntegrated into UniProtKB/TrEMBL: December 11, 2013
Last sequence update: December 11, 2013
Last modified: October 25, 2017
This is version 23 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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