UniProtKB - U3PXY2 (U3PXY2_HUMAN)
Protein
Submitted name:
HLA class II histocompatibility antigen DQ beta chain
Gene
HLA-DQB1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Biological processi
- adaptive immune response Source: UniProtKB-KW
- antigen processing and presentation of peptide or polysaccharide antigen via MHC class II Source: UniProtKB-KW
Keywordsi
Biological process | Adaptive immunity, Immunity |
Names & Taxonomyi
Protein namesi | Submitted name: HLA class II histocompatibility antigen DQ beta chainImportedSubmitted name: MHC class II antigenImportedSubmitted name: MHC class II histocompatibility antigenImported |
Gene namesi | Name:HLA-DQB1Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Lysosome
- Lysosome membrane ARBA annotation; Single-pass type I membrane protein ARBA annotation
Endosome
- Endosome membrane ARBA annotation; Single-pass type I membrane protein ARBA annotation
Endosome
- endosome membrane Source: UniProtKB-SubCell
Lysosome
- lysosomal membrane Source: UniProtKB-SubCell
Plasma Membrane
- MHC class II protein complex Source: UniProtKB-KW
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 231 – 251 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
EndosomeARBA annotation, LysosomeARBA annotation, Membrane, MHC IIARBA annotationPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 32 | Sequence analysisAdd BLAST | 32 | |
ChainiPRO_5010152828 | 33 – 269 | Sequence analysisAdd BLAST | 237 |
Keywords - PTMi
Disulfide bondARBA annotation, GlycoproteinARBA annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 129 – 217 | Ig-likeInterPro annotationAdd BLAST | 89 |
Keywords - Domaini
SignalSequence analysisARBA annotation, Transmembrane, Transmembrane helixSequence analysisFamily and domain databases
Gene3Di | 2.60.40.10, 1 hit 3.10.320.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003006, Ig/MHC_CS IPR003597, Ig_C1-set IPR011162, MHC_I/II-like_Ag-recog IPR014745, MHC_II_a/b_N IPR000353, MHC_II_b_N |
Pfami | View protein in Pfam PF07654, C1-set, 1 hit PF00969, MHC_II_beta, 1 hit |
SMARTi | View protein in SMART SM00407, IGc1, 1 hit SM00921, MHC_II_beta, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF54452, SSF54452, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS00290, IG_MHC, 1 hit |
i Sequence
Sequence statusi: Complete.
U3PXY2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSWKKALRIP GGLRAPTVTL MLAMLSTPVA EGRDPPEDFV LQFKAMCYFT
60 70 80 90 100
NGTERVRYVT RYIYNREEDV RFDSDVGVYR AVTPQGRPDA EYWNSQKDIL
110 120 130 140 150
ERTRAELDTV CRHNYEVAFR GILQRRVEPT VTISPSRTEA LNHHNLLVCS
160 170 180 190 200
VTDFYPGQIK VRWFRNDQEE TAGVVSTPLI RNGDWTFQIL VMLEMTPQHG
210 220 230 240 250
DVYTCHVEHP SLQSPITVEW RAQSESAQNK MLSGIGGFVL GLIFLGLGLI
260
IRQRSQKGPQ GPPPAGLLH
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | KF270550 Genomic DNA Translation: AGW82945.1 KF270551 Genomic DNA Translation: AGW82946.1 MH577320 Genomic DNA Translation: AXU93762.1 LC257871 Genomic DNA Translation: BBD34189.1 LC257872 Genomic DNA Translation: BBD34190.1 LC257873 Genomic DNA Translation: BBD34191.1 LR777704 Genomic DNA Translation: CAB0472738.1 LR777784 Genomic DNA Translation: CAB0472818.1 LR777786 Genomic DNA Translation: CAB0472820.1 LR777792 Genomic DNA Translation: CAB0472826.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | KF270550 Genomic DNA Translation: AGW82945.1 KF270551 Genomic DNA Translation: AGW82946.1 MH577320 Genomic DNA Translation: AXU93762.1 LC257871 Genomic DNA Translation: BBD34189.1 LC257872 Genomic DNA Translation: BBD34190.1 LC257873 Genomic DNA Translation: BBD34191.1 LR777704 Genomic DNA Translation: CAB0472738.1 LR777784 Genomic DNA Translation: CAB0472818.1 LR777786 Genomic DNA Translation: CAB0472820.1 LR777792 Genomic DNA Translation: CAB0472826.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Miscellaneous databases
ChiTaRSi | HLA-DQB1, human |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 3.10.320.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003006, Ig/MHC_CS IPR003597, Ig_C1-set IPR011162, MHC_I/II-like_Ag-recog IPR014745, MHC_II_a/b_N IPR000353, MHC_II_b_N |
Pfami | View protein in Pfam PF07654, C1-set, 1 hit PF00969, MHC_II_beta, 1 hit |
SMARTi | View protein in SMART SM00407, IGc1, 1 hit SM00921, MHC_II_beta, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF54452, SSF54452, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS00290, IG_MHC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | U3PXY2_HUMAN | |
Accessioni | U3PXY2Primary (citable) accession number: U3PXY2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | December 11, 2013 |
Last sequence update: | December 11, 2013 | |
Last modified: | December 2, 2020 | |
This is version 41 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |