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Entry version 43 (02 Dec 2020)
Sequence version 1 (11 Dec 2013)
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Protein

3C-like proteinase

Gene

Pp1a

Organism
Human coronavirus HKU1 (HCoV-HKU1)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • TSAVLQ-|-SGFRK-NH(2) and SGVTFQ-|-GKFKK the two peptides corresponding to the two self-cleavage sites of the SARS 3C-like proteinase are the two most reactive peptide substrates. The enzyme exhibits a strong preference for substrates containing Gln at P1 position and Leu at P2 position.ARBA annotation EC:3.4.22.69
  • Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).ARBA annotation EC:3.4.19.12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, RNA-bindingARBA annotation, Thiol proteaseARBA annotation
Biological processActivation of host autophagy by virusARBA annotation, Decay of host mRNAs by virusARBA annotation, Eukaryotic host gene expression shutoff by virus, Eukaryotic host translation shutoff by virusARBA annotation, Host gene expression shutoff by virus, Host mRNA suppression by virus, Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host interferon signaling pathway by virus, Inhibition of host ISG15 by virusARBA annotation, Modulation of host ubiquitin pathway by viral deubiquitinaseARBA annotation, Modulation of host ubiquitin pathway by virus, Ubl conjugation pathwayARBA annotation, Viral immunoevasion
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
3C-like proteinaseARBA annotation (EC:3.4.19.12ARBA annotation, EC:3.4.22.69ARBA annotation)
Alternative name(s):
Growth factor-like peptideARBA annotation
M-PROARBA annotation
Non-structural protein 10ARBA annotation
Non-structural protein 2ARBA annotation
Non-structural protein 3ARBA annotation
Non-structural protein 4ARBA annotation
Non-structural protein 6ARBA annotation
Non-structural protein 7ARBA annotation
Non-structural protein 8ARBA annotation
Non-structural protein 9ARBA annotation
Peptide HD2ARBA annotation
nsp5ARBA annotation
p10ARBA annotation
p12ARBA annotation
p15ARBA annotation
p210ARBA annotation
p22ARBA annotation
p27ARBA annotation
p28ARBA annotation
p44ARBA annotation
p65ARBA annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Pp1aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHuman coronavirus HKU1 (HCoV-HKU1)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri290028 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesRiboviriaOrthornaviraePisuviricotaPisoniviricetesNidoviralesCornidovirineaeCoronaviridaeOrthocoronavirinaeBetacoronavirusEmbecovirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiHomo sapiens (Human) [TaxID: 9606]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000143896 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome
  • UP000139452 Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei2264 – 2281HelicalSequence analysisAdd BLAST18
Transmembranei2317 – 2338HelicalSequence analysisAdd BLAST22
Transmembranei2350 – 2371HelicalSequence analysisAdd BLAST22
Transmembranei2440 – 2462HelicalSequence analysisAdd BLAST23
Transmembranei2474 – 2496HelicalSequence analysisAdd BLAST23
Transmembranei2879 – 2898HelicalSequence analysisAdd BLAST20
Transmembranei3149 – 3173HelicalSequence analysisAdd BLAST25
Transmembranei3180 – 3200HelicalSequence analysisAdd BLAST21
Transmembranei3238 – 3266HelicalSequence analysisAdd BLAST29
Transmembranei3683 – 3706HelicalSequence analysisAdd BLAST24
Transmembranei3712 – 3731HelicalSequence analysisAdd BLAST20
Transmembranei3738 – 3758HelicalSequence analysisAdd BLAST21
Transmembranei3778 – 3800HelicalSequence analysisAdd BLAST23
Transmembranei3807 – 3828HelicalSequence analysisAdd BLAST22
Transmembranei3834 – 3863HelicalSequence analysisAdd BLAST30
Transmembranei3875 – 3896HelicalSequence analysisAdd BLAST22

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasmARBA annotation, Host membraneARBA annotation, Membrane

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1158 – 1408Peptidase C16InterPro annotationAdd BLAST251
Domaini1386 – 1557MacroInterPro annotationAdd BLAST172
Domaini1753 – 2013Peptidase C16InterPro annotationAdd BLAST261
Domaini3370 – 3672Peptidase C30InterPro annotationAdd BLAST303

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni947 – 1125DisorderedSequence analysisAdd BLAST179

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the coronaviruses polyprotein 1ab family.ARBA annotation

Keywords - Domaini

RepeatARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotation, Zinc-fingerARBA annotation

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.150.420, 1 hit
1.10.1840.10, 1 hit
1.10.8.1190, 1 hit
1.10.8.370, 1 hit
2.40.10.10, 2 hits
2.40.10.250, 1 hit
2.40.10.290, 1 hit
3.10.20.350, 1 hit
3.10.20.540, 1 hit
3.40.220.10, 1 hit
3.90.70.90, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR022570, B-CoV_NSP1
IPR043613, CoV_NSP2_C
IPR043611, CoV_NSP3_C
IPR043612, CoV_NSP4_N
IPR043610, CoV_NSP6
IPR002589, Macro_dom
IPR043472, Macro_dom-like
IPR036333, NSP10_sf_CoV
IPR032592, NSP3_NAR_bCoV
IPR038083, NSP3A-like
IPR032505, NSP4_C_CoV
IPR038123, NSP4_C_sf_CoV
IPR014828, NSP7_CoV
IPR037204, NSP7_sf_CoV
IPR014829, NSP8_CoV-like
IPR037230, NSP8_sf_CoV
IPR014822, NSP9_CoV
IPR036499, NSP9_sf_CoV
IPR002705, Pept_C30/C16_B_coronavir
IPR013016, Peptidase_C16_CoV
IPR008740, Peptidase_C30_CoV
IPR043477, Peptidase_C30_dom3_CoV
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR043177, PLpro_N_sf_CoV
IPR043503, PLpro_palm_finger_dom_CoV
IPR043178, PLpro_thumb_sf_CoV
IPR018995, RNA_synth_NSP10_CoV

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16251, bCoV_NAR, 1 hit
PF09401, CoV_NSP10, 1 hit
PF19212, CoV_NSP2_C, 1 hit
PF19218, CoV_NSP3_C, 1 hit
PF16348, CoV_NSP4_C, 1 hit
PF19217, CoV_NSP4_N, 1 hit
PF19213, CoV_NSP6, 1 hit
PF08716, CoV_NSP7, 1 hit
PF08717, CoV_NSP8, 1 hit
PF08710, CoV_NSP9, 1 hit
PF08715, CoV_peptidase, 1 hit
PF11963, DUF3477, 1 hit
PF01661, Macro, 1 hit
PF01831, Peptidase_C16, 1 hit
PF05409, Peptidase_C30, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00506, A1pp, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF101816, SSF101816, 1 hit
SSF140367, SSF140367, 1 hit
SSF143076, SSF143076, 1 hit
SSF144246, SSF144246, 1 hit
SSF159936, SSF159936, 1 hit
SSF50494, SSF50494, 1 hit
SSF52949, SSF52949, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51442, M_PRO, 1 hit
PS51154, MACRO, 1 hit
PS51124, PEPTIDASE_C16, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

U3N895-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIKTSKYGLG FKWAPEFRWL LPDAAEELAS PMKSDEGGLC PSTGQAMESV
60 70 80 90 100
GFVYDNHVKI DCRCILGQEW HVQSNLIRDI FVHEDLHVVE VLTKTAVKSG
110 120 130 140 150
TAILIKSPLH SLGGFPKGYV MGLFRSYKTK RYVVHHLSMT TSTTNFGEDF
160 170 180 190 200
LGWIVPFGFM PSYVHKWFQF CRLYIEESDL IISNFKFDDY DFSVEDVYAE
210 220 230 240 250
VHAEPKGKYS QKAYALLRQY RGIKPVLFVD QYGCDYSGKL ADCLQAYGHY
260 270 280 290 300
SLQDMRQKQS VWLANCDFDI VVAWHVVRDS RFVMRLQTIA TICGIKYVAQ
310 320 330 340 350
PTEDVVDGDV VIREPVHLLS ADAIVLKLPS LMKVMTHMDD FSIKSIYNVD
360 370 380 390 400
LCDCGFVMQY GYVDCFNDNC DFYGWVSGNM MDGFSCPLCC TVYDSSEVKA
410 420 430 440 450
QSSGVIPENP VLFTNSTDTV NHDSFNLYGY SVTPFGSCIY WSPRPGLWIP
460 470 480 490 500
IIKSSVKSYD DLVYSGVVGC KSIVKETALI THALYLDYVQ CKCGNLEQNH
510 520 530 540 550
ILGVNNSWCR QLLLNRGDYN MLLKNIDLFV KRRADFACKF AVCGDGFVPF
560 570 580 590 600
LLDGLIPRSY YLIQSGIFFT SLMSQFSQEV SDMCLKMCIL FMDRVSVATF
610 620 630 640 650
YIEHYVNRLV TQFKLLGTTL VNKMVNWFNT MLDASAPATG WLLYQLLNGL
660 670 680 690 700
FVVSQANFNF VALIPDYAKI LVNKFYTFFK LLLECVTVDV LKDMPVLKTI
710 720 730 740 750
NGLVCIVGNK FYNVSTGLIP GFVLPCNAQE QQIYFFEGVA ESVIVEDDVI
760 770 780 790 800
ENVKSSLSSY EYCQPPKSVE KICIIDNMYM GKCGDKFFPI VMNDKNICLL
810 820 830 840 850
DQAWRFPCAG RKVNFNEKPV VMEIPSLMTV KVMFDLDSTF DDILGKVCSE
860 870 880 890 900
FEVEKGVTVD DFVAVVCDAI ENALNSCKEH PVVGYQVRAF LNKLNDNVVY
910 920 930 940 950
LFDEAGDEAM ASRMYCTFAI EDVEDVISSE AVEDTIDGIV EDTINDDEDV
960 970 980 990 1000
VTGDNDDEDV VTGDNDDEDV VTGDNDDEDV VTGDNDDEDV VTGDNDDEDV
1010 1020 1030 1040 1050
VTGDNDDEDV VTGDNDDEDV VTGDNDDEDV VTGDNDDEDV VTGDNDDEDV
1060 1070 1080 1090 1100
VTGDNDDEDV VTGDNDDEDV VTGDNDDEDV VTGDNDDEDV VTGDNDDEDV
1110 1120 1130 1140 1150
VTGDNDDEDV VTGDNDDEDN NDEEIVTGDN DDQIVVTGDD VDDIESIYDF
1160 1170 1180 1190 1200
DTYKALLVFN DVYNDALFVS YGSSVETETY FKVNGLWSPT ITHTNCWLRS
1210 1220 1230 1240 1250
VLLVMQKLPF KFKDLAIENM WLSYKVGYNQ SFVDYLLTTI PKAIVLPQGG
1260 1270 1280 1290 1300
FVADFAYWFL NQFDINAYAN WCCLKCGFSF DLNGLDALFF YGDIVSHVCK
1310 1320 1330 1340 1350
CGHNMTLIAA DLPCTLHFSL FDDNFCAFCT PKKIFIAACA VDVNVCHSVA
1360 1370 1380 1390 1400
VIGDEQIDGK FVTKFSGDKF DFIVGYGMSF SMSSFELAQL YGLCITPNVC
1410 1420 1430 1440 1450
FVKGDIINVA RLVKADVIVN PANGHMLHGG GVAKAIAVAA GKKFSKETAA
1460 1470 1480 1490 1500
MVKSKGVCQV GDCYVSTGGK LCKTILNIVG PDARQDGRQS YVLLARAYKH
1510 1520 1530 1540 1550
LNNYDCCLST LISAGIFSVP ADVSLTYLLG VVDKQVILVS NNKEDFDIIQ
1560 1570 1580 1590 1600
KCQITSVVGT KALAVRLTAN VGRVIKFETD AYKLFLSGDD CFVSNSSVIQ
1610 1620 1630 1640 1650
EVLLLRHDIQ LNNDVRDYLL SKMTSLPKDW RLINKFDVIN GVKTVKYFEC
1660 1670 1680 1690 1700
PNSIYICSQG KDFGYVCDGS FYKATVNQVC VLLAKKIDVL LTVDGVNFKS
1710 1720 1730 1740 1750
ISLTVGEVFG KILGNVFCDG IDVTKLKCSD FYADKILYQY ENLSLADISA
1760 1770 1780 1790 1800
VQSSFGFDQQ QLLAYYNFLT VCKWSVVVNG PFFSFEQSHN NCYVNVACLM
1810 1820 1830 1840 1850
LQHINLKFNK WQWQEAWYEF RAGRPHRLVA LVLAKGHFKF DEPSDATDFI
1860 1870 1880 1890 1900
RVVLKQADLS GAICELELIC DCGIKQESRV GVDAVMHFGT LAKTDLFNGY
1910 1920 1930 1940 1950
KIGCNCAGRI VHCTKLNVPF LICSNTPLSK DLPDDVVAAN MFMGVGVGHY
1960 1970 1980 1990 2000
THLKCGSPYQ HYDACSVKKY TGVSGCLTDC LYLKNLTQTF TSMLTNYFLD
2010 2020 2030 2040 2050
DVEMVAYNPD LSQYYCDNGK YYTKPIIKAQ FKPFAKVDGV YTNFKLVGHD
2060 2070 2080 2090 2100
ICAQLNDKLG FNVDLPFVEY KVTVWPVATG DVVLASDDLY VKRYFKGCET
2110 2120 2130 2140 2150
FGKPVIWFCH DEASLNSLTY FNKPSFKSEN RYSVLSVDSV SEESQGNVVT
2160 2170 2180 2190 2200
PVMESQISTK EVKLKGVRKT VKIEDAIIVN DENSSIKVVK SLSLVDVWDM
2210 2220 2230 2240 2250
YLTGCDYVVW VANELSRLVK SPTVREYIRY GIKPITIPID LLCLRDDNQT
2260 2270 2280 2290 2300
LLVPKIFKAR AIEFYGFLKW LFIYVFSLLH FTNDKTIFYT TEIASKFTFN
2310 2320 2330 2340 2350
LFCLALKNAF QTFRWSIFIK GFLVVATVFL FWFNFLYINV IFSDFYLPNI
2360 2370 2380 2390 2400
SVFPIFVGRI VMWIKATFGL VTICDFYSKL GVGFTSHFCN GSFICELCHS
2410 2420 2430 2440 2450
GFDMLDTYAA IDFVQYEVDR RVLFDYVSLV KLIVELVIGY SLYTVWFYPL
2460 2470 2480 2490 2500
FCLIGLQLFT TWLPDLFMLE TMHWLIRFIV FVANMLPAFV LLRFYIVVTA
2510 2520 2530 2540 2550
MYKVVGFIRH IVYGCNKAGC LFCYKRNCSV RVKCSTIVGG VIRYYDITAN
2560 2570 2580 2590 2600
GGTGFCVKHQ WNCFNCHSFK PGNTFITVEA AIELSKELKR PVNPTDASHY
2610 2620 2630 2640 2650
VVTDIKQVGC MMRLFYDRDG QRVYDDVDAS LFVDINNLLH SKVKVVPNLY
2660 2670 2680 2690 2700
VVVVESDADR ANFLNAVVFY AQSLYRPILL VDKKLITTAC NGISVTQTMF
2710 2720 2730 2740 2750
DVYVDTFMSH FDVDRKSFNN FVNIAHASLR EGVQLEKVLD TFVGCVRKCC
2760 2770 2780 2790 2800
SIDSDVETRF ITKSMISAVA AGLEFTDENY NNLVPTYLKS DNIVAADLGV
2810 2820 2830 2840 2850
LIQNGAKHVQ GNVAKAANIS CIWFIDAFNQ LTADLQHKLK KACVKTGLKL
2860 2870 2880 2890 2900
KLTFNKQEAS VPILTTPFSL KGGVVLSNLL YILFFVSLIC FILLWALLPT
2910 2920 2930 2940 2950
YSVYKSDIHL PAYASFKVID NGVVRDISVN DLCFANKFFQ FDQWYESTFG
2960 2970 2980 2990 3000
SVYYHNSMDC PIVVAVMDED IGSTMFNVPT KVLRHGFHVL HFLTYAFASD
3010 3020 3030 3040 3050
SVQCYTPHIQ ISYNDFYASG CVLSSLCTMF KRGDGTPHPY CYSDGVMKNA
3060 3070 3080 3090 3100
SLYTSLVPHT RYSLANSNGF IRFPDVISEG IVRIVRTRSM TYCRVGACEY
3110 3120 3130 3140 3150
AEEGICFNFN SSWVLNNDYY RSMPGTFCGR DLFDLFYQFF SSLIRPIDFF
3160 3170 3180 3190 3200
SLTASSIFGA ILAIVVVLVF YYLIKLKRAF GDYTSVVVIN VVVWCINFLM
3210 3220 3230 3240 3250
LFVFQVYPIC ACVYACFYFY VTLYFPSEIS VIMHLQWIVM YGAIMPFWFC
3260 3270 3280 3290 3300
VTYVAMVIAN HVLWLFSYCR KIGVNVCSDS TFEETSLTTF MITKDSYCRL
3310 3320 3330 3340 3350
KNSVSDVAYN RYLSLYNKYR YYSGKMDTAA YREAACSQLA KAMETFNHNN
3360 3370 3380 3390 3400
GNDVLYQPPT ASVSTSFLQS GIVKMVSPTS KIEPCIVSVT YGSMTLNGLW
3410 3420 3430 3440 3450
LDDKVYCPRH VICSSSNMNE PDYSALLCRV TLGDFTIMSG RMSLTVVSYQ
3460 3470 3480 3490 3500
MQGCQLVLTV SLQNPYTPKY TFGNVKPGET FTVLAAYNGR PQGAFHVTMR
3510 3520 3530 3540 3550
SSYTIKGSFL CGSCGSVGYV LTGDSVKFVY MHQLELSTGC HTGTDFTGNF
3560 3570 3580 3590 3600
YGPYRDAQVV QLPVKDYVQT VNVIAWLYAA ILNNCAWFVQ NDVCSTEDFN
3610 3620 3630 3640 3650
VWAMANGFSQ VKADLVLDAL ASMTGVSIET LLAAIKRLYM GFQGRQILGS
3660 3670 3680 3690 3700
CTFEDELAPS DVYQQLAGVK LQSKTKRFIK ETIYWILIST FLFSCIISAF
3710 3720 3730 3740 3750
VKWTIFMYIN THMIGVTLCV LCFVSFMMLL VKHKHFYLTM YIIPVLCTLF
3760 3770 3780 3790 3800
YVNYLVVYKE GFRGFTYVWL SYFVPAVNFT YVYEVFYGCI LCVFAIFITM
3810 3820 3830 3840 3850
HSINHDIFSL MFLVGRIVTL ISMWYFGSNL EEDVLLFITA FLGTYTWTTI
3860 3870 3880 3890 3900
LSLAIAKIVA NWLSVNIFYF TDVPYIKLIL LSYLFIGYIL SCYWGFFSLL
3910 3920 3930 3940 3950
NSVFRMPMGV YNYKISVQEL RYMNANGLRP PRNSFEAILL NLKLLGIGGV
3960 3970 3980 3990 4000
PVIEVSQIQS KLTDVKCANV VLLNCLQHLH VASNSKLWQY CSVLHNEILS
4010 4020 4030 4040 4050
TSDLSVAFDK LAQLLIVLFA NPAAVDTKCL ASIDEVSDDY VQDSTVLQAL
4060 4070 4080 4090 4100
QSEFVNMASF VEYEVAKKNL ADAKNSGSVN QQQIKQLEKA CNIAKSVYER
4110 4120 4130 4140 4150
DKAVARKLER MADLALTNMY KEARINDKKS KVVSALQTML FSMVRKLDNQ
4160 4170 4180 4190 4200
ALNSILDNAV KGCVPLSAIP ALAANTLTII IPDKQVFDKV VDNVYVTYAG
4210 4220 4230 4240 4250
SVWHIQTVQD ADGINKQLTD ISVDSNWPLV IIANRYNEVA NAVMQNNELM
4260 4270 4280 4290 4300
PHKLKIQVVN SGSDMNCNIP TQCYYNNGSS GRIVYAVLSD VDGLKYTKIM
4310 4320 4330 4340 4350
KDDGNCVVLE LDPPCKFSIQ DVKGLKIKYL YFIKGCNTLA RGWVVGTLSS
4360 4370 4380 4390 4400
TIRLQAGVAT EYAANSSILS LCAFSVDPKK TYLDYIQQGG VPIINCVKML
4410 4420 4430 4440 4450
CDHAGTGMAI TIKPEATINQ DSYGGASVCI YCRARVEHPD VDGICKLRGK
4460 4470 4480 4490 4500
FVQVPLGIKD PILYVLTHDV CQVCGFWRDG SCSCVGSSVA VQSKDLNFLN

GFGVLV
Length:4,506
Mass (Da):506,384
Last modified:December 11, 2013 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i38D76F55C1781FFD
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
KF686343 Genomic RNA Translation: AGW27860.1
KF686346 Genomic RNA Translation: AGW27878.1

Keywords - Coding sequence diversityi

Ribosomal frameshiftingARBA annotation

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KF686343 Genomic RNA Translation: AGW27860.1
KF686346 Genomic RNA Translation: AGW27878.1

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Family and domain databases

Gene3Di1.10.150.420, 1 hit
1.10.1840.10, 1 hit
1.10.8.1190, 1 hit
1.10.8.370, 1 hit
2.40.10.10, 2 hits
2.40.10.250, 1 hit
2.40.10.290, 1 hit
3.10.20.350, 1 hit
3.10.20.540, 1 hit
3.40.220.10, 1 hit
3.90.70.90, 2 hits
InterProiView protein in InterPro
IPR022570, B-CoV_NSP1
IPR043613, CoV_NSP2_C
IPR043611, CoV_NSP3_C
IPR043612, CoV_NSP4_N
IPR043610, CoV_NSP6
IPR002589, Macro_dom
IPR043472, Macro_dom-like
IPR036333, NSP10_sf_CoV
IPR032592, NSP3_NAR_bCoV
IPR038083, NSP3A-like
IPR032505, NSP4_C_CoV
IPR038123, NSP4_C_sf_CoV
IPR014828, NSP7_CoV
IPR037204, NSP7_sf_CoV
IPR014829, NSP8_CoV-like
IPR037230, NSP8_sf_CoV
IPR014822, NSP9_CoV
IPR036499, NSP9_sf_CoV
IPR002705, Pept_C30/C16_B_coronavir
IPR013016, Peptidase_C16_CoV
IPR008740, Peptidase_C30_CoV
IPR043477, Peptidase_C30_dom3_CoV
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR043177, PLpro_N_sf_CoV
IPR043503, PLpro_palm_finger_dom_CoV
IPR043178, PLpro_thumb_sf_CoV
IPR018995, RNA_synth_NSP10_CoV
PfamiView protein in Pfam
PF16251, bCoV_NAR, 1 hit
PF09401, CoV_NSP10, 1 hit
PF19212, CoV_NSP2_C, 1 hit
PF19218, CoV_NSP3_C, 1 hit
PF16348, CoV_NSP4_C, 1 hit
PF19217, CoV_NSP4_N, 1 hit
PF19213, CoV_NSP6, 1 hit
PF08716, CoV_NSP7, 1 hit
PF08717, CoV_NSP8, 1 hit
PF08710, CoV_NSP9, 1 hit
PF08715, CoV_peptidase, 1 hit
PF11963, DUF3477, 1 hit
PF01661, Macro, 1 hit
PF01831, Peptidase_C16, 1 hit
PF05409, Peptidase_C30, 1 hit
SMARTiView protein in SMART
SM00506, A1pp, 1 hit
SUPFAMiSSF101816, SSF101816, 1 hit
SSF140367, SSF140367, 1 hit
SSF143076, SSF143076, 1 hit
SSF144246, SSF144246, 1 hit
SSF159936, SSF159936, 1 hit
SSF50494, SSF50494, 1 hit
SSF52949, SSF52949, 1 hit
PROSITEiView protein in PROSITE
PS51442, M_PRO, 1 hit
PS51154, MACRO, 1 hit
PS51124, PEPTIDASE_C16, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiU3N895_CVHK1
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: U3N895
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 11, 2013
Last sequence update: December 11, 2013
Last modified: December 2, 2020
This is version 43 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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