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UniProtKB - U3N895 (U3N895_CVHK1)

Entry version 43 (02 Dec 2020)
Sequence version 1 (11 Dec 2013)
Previous versions | rss
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Protein

3C-like proteinase

Gene

Pp1a

Organism
Human coronavirus HKU1 (HCoV-HKU1)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • TSAVLQ-|-SGFRK-NH(2) and SGVTFQ-|-GKFKK the two peptides corresponding to the two self-cleavage sites of the SARS 3C-like proteinase are the two most reactive peptide substrates. The enzyme exhibits a strong preference for substrates containing Gln at P1 position and Leu at P2 position.ARBA annotation EC:3.4.22.69
  • Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).ARBA annotation EC:3.4.19.12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, RNA-bindingARBA annotation, Thiol proteaseARBA annotation
Biological processActivation of host autophagy by virusARBA annotation, Decay of host mRNAs by virusARBA annotation, Eukaryotic host gene expression shutoff by virus, Eukaryotic host translation shutoff by virusARBA annotation, Host gene expression shutoff by virus, Host mRNA suppression by virus, Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host interferon signaling pathway by virus, Inhibition of host ISG15 by virusARBA annotation, Modulation of host ubiquitin pathway by viral deubiquitinaseARBA annotation, Modulation of host ubiquitin pathway by virus, Ubl conjugation pathwayARBA annotation, Viral immunoevasion
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
3C-like proteinaseARBA annotation (EC:3.4.19.12ARBA annotation, EC:3.4.22.69ARBA annotation)
Alternative name(s):
Growth factor-like peptideARBA annotation
M-PROARBA annotation
Non-structural protein 10ARBA annotation
Non-structural protein 2ARBA annotation
Non-structural protein 3ARBA annotation
Non-structural protein 4ARBA annotation
Non-structural protein 6ARBA annotation
Non-structural protein 7ARBA annotation
Non-structural protein 8ARBA annotation
Non-structural protein 9ARBA annotation
Peptide HD2ARBA annotation
nsp5ARBA annotation
p10ARBA annotation
p12ARBA annotation
p15ARBA annotation
p210ARBA annotation
p22ARBA annotation
p27ARBA annotation
p28ARBA annotation
p44ARBA annotation
p65ARBA annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Pp1aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHuman coronavirus HKU1 (HCoV-HKU1)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri290028 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiViruses › Riboviria › Orthornavirae › Pisuviricota › Pisoniviricetes › Nidovirales › Cornidovirineae › Coronaviridae › Orthocoronavirinae › Betacoronavirus › Embecovirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiHomo sapiens (Human) [TaxID: 9606]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000143896 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome
  • UP000139452 Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei2264 – 2281HelicalSequence analysisAdd BLAST18
Transmembranei2317 – 2338HelicalSequence analysisAdd BLAST22
Transmembranei2350 – 2371HelicalSequence analysisAdd BLAST22
Transmembranei2440 – 2462HelicalSequence analysisAdd BLAST23
Transmembranei2474 – 2496HelicalSequence analysisAdd BLAST23
Transmembranei2879 – 2898HelicalSequence analysisAdd BLAST20
Transmembranei3149 – 3173HelicalSequence analysisAdd BLAST25
Transmembranei3180 – 3200HelicalSequence analysisAdd BLAST21
Transmembranei3238 – 3266HelicalSequence analysisAdd BLAST29
Transmembranei3683 – 3706HelicalSequence analysisAdd BLAST24
Transmembranei3712 – 3731HelicalSequence analysisAdd BLAST20
Transmembranei3738 – 3758HelicalSequence analysisAdd BLAST21
Transmembranei3778 – 3800HelicalSequence analysisAdd BLAST23
Transmembranei3807 – 3828HelicalSequence analysisAdd BLAST22
Transmembranei3834 – 3863HelicalSequence analysisAdd BLAST30
Transmembranei3875 – 3896HelicalSequence analysisAdd BLAST22

GO - Cellular componenti

Complete GO annotation on QuickGO ...

Keywords - Cellular componenti

Host cytoplasmARBA annotation, Host membraneARBA annotation, Membrane

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1158 – 1408Peptidase C16InterPro annotationAdd BLAST251
Domaini1386 – 1557MacroInterPro annotationAdd BLAST172
Domaini1753 – 2013Peptidase C16InterPro annotationAdd BLAST261
Domaini3370 – 3672Peptidase C30InterPro annotationAdd BLAST303

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni947 – 1125DisorderedSequence analysisAdd BLAST179

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the coronaviruses polyprotein 1ab family.ARBA annotation

Keywords - Domaini

RepeatARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotation, Zinc-fingerARBA annotation

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.150.420, 1 hit
1.10.1840.10, 1 hit
1.10.8.1190, 1 hit
1.10.8.370, 1 hit
2.40.10.10, 2 hits
2.40.10.250, 1 hit
2.40.10.290, 1 hit
3.10.20.350, 1 hit
3.10.20.540, 1 hit
3.40.220.10, 1 hit
3.90.70.90, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR022570, B-CoV_NSP1
IPR043613, CoV_NSP2_C
IPR043611, CoV_NSP3_C
IPR043612, CoV_NSP4_N
IPR043610, CoV_NSP6
IPR002589, Macro_dom
IPR043472, Macro_dom-like
IPR036333, NSP10_sf_CoV
IPR032592, NSP3_NAR_bCoV
IPR038083, NSP3A-like
IPR032505, NSP4_C_CoV
IPR038123, NSP4_C_sf_CoV
IPR014828, NSP7_CoV
IPR037204, NSP7_sf_CoV
IPR014829, NSP8_CoV-like
IPR037230, NSP8_sf_CoV
IPR014822, NSP9_CoV
IPR036499, NSP9_sf_CoV
IPR002705, Pept_C30/C16_B_coronavir
IPR013016, Peptidase_C16_CoV
IPR008740, Peptidase_C30_CoV
IPR043477, Peptidase_C30_dom3_CoV
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR043177, PLpro_N_sf_CoV
IPR043503, PLpro_palm_finger_dom_CoV
IPR043178, PLpro_thumb_sf_CoV
IPR018995, RNA_synth_NSP10_CoV

Pfam protein domain database

More...Pfami		View protein in Pfam
PF16251, bCoV_NAR, 1 hit
PF09401, CoV_NSP10, 1 hit
PF19212, CoV_NSP2_C, 1 hit
PF19218, CoV_NSP3_C, 1 hit
PF16348, CoV_NSP4_C, 1 hit
PF19217, CoV_NSP4_N, 1 hit
PF19213, CoV_NSP6, 1 hit
PF08716, CoV_NSP7, 1 hit
PF08717, CoV_NSP8, 1 hit
PF08710, CoV_NSP9, 1 hit
PF08715, CoV_peptidase, 1 hit
PF11963, DUF3477, 1 hit
PF01661, Macro, 1 hit
PF01831, Peptidase_C16, 1 hit
PF05409, Peptidase_C30, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00506, A1pp, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF101816, SSF101816, 1 hit
SSF140367, SSF140367, 1 hit
SSF143076, SSF143076, 1 hit
SSF144246, SSF144246, 1 hit
SSF159936, SSF159936, 1 hit
SSF50494, SSF50494, 1 hit
SSF52949, SSF52949, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51442, M_PRO, 1 hit
PS51154, MACRO, 1 hit
PS51124, PEPTIDASE_C16, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

U3N895-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIKTSKYGLG FKWAPEFRWL LPDAAEELAS PMKSDEGGLC PSTGQAMESV 
        60         70         80         90        100
GFVYDNHVKI DCRCILGQEW HVQSNLIRDI FVHEDLHVVE VLTKTAVKSG 
       110        120        130        140        150
TAILIKSPLH SLGGFPKGYV MGLFRSYKTK RYVVHHLSMT TSTTNFGEDF 
       160        170        180        190        200
LGWIVPFGFM PSYVHKWFQF CRLYIEESDL IISNFKFDDY DFSVEDVYAE 
       210        220        230        240        250
VHAEPKGKYS QKAYALLRQY RGIKPVLFVD QYGCDYSGKL ADCLQAYGHY 
       260        270        280        290        300
SLQDMRQKQS VWLANCDFDI VVAWHVVRDS RFVMRLQTIA TICGIKYVAQ 
       310        320        330        340        350
PTEDVVDGDV VIREPVHLLS ADAIVLKLPS LMKVMTHMDD FSIKSIYNVD 
       360        370        380        390        400
LCDCGFVMQY GYVDCFNDNC DFYGWVSGNM MDGFSCPLCC TVYDSSEVKA 
       410        420        430        440        450
QSSGVIPENP VLFTNSTDTV NHDSFNLYGY SVTPFGSCIY WSPRPGLWIP 
       460        470        480        490        500
IIKSSVKSYD DLVYSGVVGC KSIVKETALI THALYLDYVQ CKCGNLEQNH 
       510        520        530        540        550
ILGVNNSWCR QLLLNRGDYN MLLKNIDLFV KRRADFACKF AVCGDGFVPF 
       560        570        580        590        600
LLDGLIPRSY YLIQSGIFFT SLMSQFSQEV SDMCLKMCIL FMDRVSVATF 
       610        620        630        640        650
YIEHYVNRLV TQFKLLGTTL VNKMVNWFNT MLDASAPATG WLLYQLLNGL 
       660        670        680        690        700
FVVSQANFNF VALIPDYAKI LVNKFYTFFK LLLECVTVDV LKDMPVLKTI 
       710        720        730        740        750
NGLVCIVGNK FYNVSTGLIP GFVLPCNAQE QQIYFFEGVA ESVIVEDDVI 
       760        770        780        790        800
ENVKSSLSSY EYCQPPKSVE KICIIDNMYM GKCGDKFFPI VMNDKNICLL 
       810        820        830        840        850
DQAWRFPCAG RKVNFNEKPV VMEIPSLMTV KVMFDLDSTF DDILGKVCSE 
       860        870        880        890        900
FEVEKGVTVD DFVAVVCDAI ENALNSCKEH PVVGYQVRAF LNKLNDNVVY 
       910        920        930        940        950
LFDEAGDEAM ASRMYCTFAI EDVEDVISSE AVEDTIDGIV EDTINDDEDV 
       960        970        980        990       1000
VTGDNDDEDV VTGDNDDEDV VTGDNDDEDV VTGDNDDEDV VTGDNDDEDV 
      1010       1020       1030       1040       1050
VTGDNDDEDV VTGDNDDEDV VTGDNDDEDV VTGDNDDEDV VTGDNDDEDV 
      1060       1070       1080       1090       1100
VTGDNDDEDV VTGDNDDEDV VTGDNDDEDV VTGDNDDEDV VTGDNDDEDV 
      1110       1120       1130       1140       1150
VTGDNDDEDV VTGDNDDEDN NDEEIVTGDN DDQIVVTGDD VDDIESIYDF 
      1160       1170       1180       1190       1200
DTYKALLVFN DVYNDALFVS YGSSVETETY FKVNGLWSPT ITHTNCWLRS 
      1210       1220       1230       1240       1250
VLLVMQKLPF KFKDLAIENM WLSYKVGYNQ SFVDYLLTTI PKAIVLPQGG 
      1260       1270       1280       1290       1300
FVADFAYWFL NQFDINAYAN WCCLKCGFSF DLNGLDALFF YGDIVSHVCK 
      1310       1320       1330       1340       1350
CGHNMTLIAA DLPCTLHFSL FDDNFCAFCT PKKIFIAACA VDVNVCHSVA 
      1360       1370       1380       1390       1400
VIGDEQIDGK FVTKFSGDKF DFIVGYGMSF SMSSFELAQL YGLCITPNVC 
      1410       1420       1430       1440       1450
FVKGDIINVA RLVKADVIVN PANGHMLHGG GVAKAIAVAA GKKFSKETAA 
      1460       1470       1480       1490       1500
MVKSKGVCQV GDCYVSTGGK LCKTILNIVG PDARQDGRQS YVLLARAYKH 
      1510       1520       1530       1540       1550
LNNYDCCLST LISAGIFSVP ADVSLTYLLG VVDKQVILVS NNKEDFDIIQ 
      1560       1570       1580       1590       1600
KCQITSVVGT KALAVRLTAN VGRVIKFETD AYKLFLSGDD CFVSNSSVIQ 
      1610       1620       1630       1640       1650
EVLLLRHDIQ LNNDVRDYLL SKMTSLPKDW RLINKFDVIN GVKTVKYFEC 
      1660       1670       1680       1690       1700
PNSIYICSQG KDFGYVCDGS FYKATVNQVC VLLAKKIDVL LTVDGVNFKS 
      1710       1720       1730       1740       1750
ISLTVGEVFG KILGNVFCDG IDVTKLKCSD FYADKILYQY ENLSLADISA 
      1760       1770       1780       1790       1800
VQSSFGFDQQ QLLAYYNFLT VCKWSVVVNG PFFSFEQSHN NCYVNVACLM 
      1810       1820       1830       1840       1850
LQHINLKFNK WQWQEAWYEF RAGRPHRLVA LVLAKGHFKF DEPSDATDFI 
      1860       1870       1880       1890       1900
RVVLKQADLS GAICELELIC DCGIKQESRV GVDAVMHFGT LAKTDLFNGY 
      1910       1920       1930       1940       1950
KIGCNCAGRI VHCTKLNVPF LICSNTPLSK DLPDDVVAAN MFMGVGVGHY 
      1960       1970       1980       1990       2000
THLKCGSPYQ HYDACSVKKY TGVSGCLTDC LYLKNLTQTF TSMLTNYFLD 
      2010       2020       2030       2040       2050
DVEMVAYNPD LSQYYCDNGK YYTKPIIKAQ FKPFAKVDGV YTNFKLVGHD 
      2060       2070       2080       2090       2100
ICAQLNDKLG FNVDLPFVEY KVTVWPVATG DVVLASDDLY VKRYFKGCET 
      2110       2120       2130       2140       2150
FGKPVIWFCH DEASLNSLTY FNKPSFKSEN RYSVLSVDSV SEESQGNVVT 
      2160       2170       2180       2190       2200
PVMESQISTK EVKLKGVRKT VKIEDAIIVN DENSSIKVVK SLSLVDVWDM 
      2210       2220       2230       2240       2250
YLTGCDYVVW VANELSRLVK SPTVREYIRY GIKPITIPID LLCLRDDNQT 
      2260       2270       2280       2290       2300
LLVPKIFKAR AIEFYGFLKW LFIYVFSLLH FTNDKTIFYT TEIASKFTFN 
      2310       2320       2330       2340       2350
LFCLALKNAF QTFRWSIFIK GFLVVATVFL FWFNFLYINV IFSDFYLPNI 
      2360       2370       2380       2390       2400
SVFPIFVGRI VMWIKATFGL VTICDFYSKL GVGFTSHFCN GSFICELCHS 
      2410       2420       2430       2440       2450
GFDMLDTYAA IDFVQYEVDR RVLFDYVSLV KLIVELVIGY SLYTVWFYPL 
      2460       2470       2480       2490       2500
FCLIGLQLFT TWLPDLFMLE TMHWLIRFIV FVANMLPAFV LLRFYIVVTA 
      2510       2520       2530       2540       2550
MYKVVGFIRH IVYGCNKAGC LFCYKRNCSV RVKCSTIVGG VIRYYDITAN 
      2560       2570       2580       2590       2600
GGTGFCVKHQ WNCFNCHSFK PGNTFITVEA AIELSKELKR PVNPTDASHY 
      2610       2620       2630       2640       2650
VVTDIKQVGC MMRLFYDRDG QRVYDDVDAS LFVDINNLLH SKVKVVPNLY 
      2660       2670       2680       2690       2700
VVVVESDADR ANFLNAVVFY AQSLYRPILL VDKKLITTAC NGISVTQTMF 
      2710       2720       2730       2740       2750
DVYVDTFMSH FDVDRKSFNN FVNIAHASLR EGVQLEKVLD TFVGCVRKCC 
      2760       2770       2780       2790       2800
SIDSDVETRF ITKSMISAVA AGLEFTDENY NNLVPTYLKS DNIVAADLGV 
      2810       2820       2830       2840       2850
LIQNGAKHVQ GNVAKAANIS CIWFIDAFNQ LTADLQHKLK KACVKTGLKL 
      2860       2870       2880       2890       2900
KLTFNKQEAS VPILTTPFSL KGGVVLSNLL YILFFVSLIC FILLWALLPT 
      2910       2920       2930       2940       2950
YSVYKSDIHL PAYASFKVID NGVVRDISVN DLCFANKFFQ FDQWYESTFG 
      2960       2970       2980       2990       3000
SVYYHNSMDC PIVVAVMDED IGSTMFNVPT KVLRHGFHVL HFLTYAFASD 
      3010       3020       3030       3040       3050
SVQCYTPHIQ ISYNDFYASG CVLSSLCTMF KRGDGTPHPY CYSDGVMKNA 
      3060       3070       3080       3090       3100
SLYTSLVPHT RYSLANSNGF IRFPDVISEG IVRIVRTRSM TYCRVGACEY 
      3110       3120       3130       3140       3150
AEEGICFNFN SSWVLNNDYY RSMPGTFCGR DLFDLFYQFF SSLIRPIDFF 
      3160       3170       3180       3190       3200
SLTASSIFGA ILAIVVVLVF YYLIKLKRAF GDYTSVVVIN VVVWCINFLM 
      3210       3220       3230       3240       3250
LFVFQVYPIC ACVYACFYFY VTLYFPSEIS VIMHLQWIVM YGAIMPFWFC 
      3260       3270       3280       3290       3300
VTYVAMVIAN HVLWLFSYCR KIGVNVCSDS TFEETSLTTF MITKDSYCRL 
      3310       3320       3330       3340       3350
KNSVSDVAYN RYLSLYNKYR YYSGKMDTAA YREAACSQLA KAMETFNHNN 
      3360       3370       3380       3390       3400
GNDVLYQPPT ASVSTSFLQS GIVKMVSPTS KIEPCIVSVT YGSMTLNGLW 
      3410       3420       3430       3440       3450
LDDKVYCPRH VICSSSNMNE PDYSALLCRV TLGDFTIMSG RMSLTVVSYQ 
      3460       3470       3480       3490       3500
MQGCQLVLTV SLQNPYTPKY TFGNVKPGET FTVLAAYNGR PQGAFHVTMR 
      3510       3520       3530       3540       3550
SSYTIKGSFL CGSCGSVGYV LTGDSVKFVY MHQLELSTGC HTGTDFTGNF 
      3560       3570       3580       3590       3600
YGPYRDAQVV QLPVKDYVQT VNVIAWLYAA ILNNCAWFVQ NDVCSTEDFN 
      3610       3620       3630       3640       3650
VWAMANGFSQ VKADLVLDAL ASMTGVSIET LLAAIKRLYM GFQGRQILGS 
      3660       3670       3680       3690       3700
CTFEDELAPS DVYQQLAGVK LQSKTKRFIK ETIYWILIST FLFSCIISAF 
      3710       3720       3730       3740       3750
VKWTIFMYIN THMIGVTLCV LCFVSFMMLL VKHKHFYLTM YIIPVLCTLF 
      3760       3770       3780       3790       3800
YVNYLVVYKE GFRGFTYVWL SYFVPAVNFT YVYEVFYGCI LCVFAIFITM 
      3810       3820       3830       3840       3850
HSINHDIFSL MFLVGRIVTL ISMWYFGSNL EEDVLLFITA FLGTYTWTTI 
      3860       3870       3880       3890       3900
LSLAIAKIVA NWLSVNIFYF TDVPYIKLIL LSYLFIGYIL SCYWGFFSLL 
      3910       3920       3930       3940       3950
NSVFRMPMGV YNYKISVQEL RYMNANGLRP PRNSFEAILL NLKLLGIGGV 
      3960       3970       3980       3990       4000
PVIEVSQIQS KLTDVKCANV VLLNCLQHLH VASNSKLWQY CSVLHNEILS 
      4010       4020       4030       4040       4050
TSDLSVAFDK LAQLLIVLFA NPAAVDTKCL ASIDEVSDDY VQDSTVLQAL 
      4060       4070       4080       4090       4100
QSEFVNMASF VEYEVAKKNL ADAKNSGSVN QQQIKQLEKA CNIAKSVYER 
      4110       4120       4130       4140       4150
DKAVARKLER MADLALTNMY KEARINDKKS KVVSALQTML FSMVRKLDNQ 
      4160       4170       4180       4190       4200
ALNSILDNAV KGCVPLSAIP ALAANTLTII IPDKQVFDKV VDNVYVTYAG 
      4210       4220       4230       4240       4250
SVWHIQTVQD ADGINKQLTD ISVDSNWPLV IIANRYNEVA NAVMQNNELM 
      4260       4270       4280       4290       4300
PHKLKIQVVN SGSDMNCNIP TQCYYNNGSS GRIVYAVLSD VDGLKYTKIM 
      4310       4320       4330       4340       4350
KDDGNCVVLE LDPPCKFSIQ DVKGLKIKYL YFIKGCNTLA RGWVVGTLSS 
      4360       4370       4380       4390       4400
TIRLQAGVAT EYAANSSILS LCAFSVDPKK TYLDYIQQGG VPIINCVKML 
      4410       4420       4430       4440       4450
CDHAGTGMAI TIKPEATINQ DSYGGASVCI YCRARVEHPD VDGICKLRGK 
      4460       4470       4480       4490       4500
FVQVPLGIKD PILYVLTHDV CQVCGFWRDG SCSCVGSSVA VQSKDLNFLN 

GFGVLV
Length:4,506
Mass (Da):506,384
Last modified:December 11, 2013 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i38D76F55C1781FFD
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
KF686343 Genomic RNA Translation: AGW27860.1
KF686346 Genomic RNA Translation: AGW27878.1

Keywords - Coding sequence diversityi

Ribosomal frameshiftingARBA annotation

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KF686343 Genomic RNA Translation: AGW27860.1
KF686346 Genomic RNA Translation: AGW27878.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Family and domain databases

Gene3Di1.10.150.420, 1 hit
1.10.1840.10, 1 hit
1.10.8.1190, 1 hit
1.10.8.370, 1 hit
2.40.10.10, 2 hits
2.40.10.250, 1 hit
2.40.10.290, 1 hit
3.10.20.350, 1 hit
3.10.20.540, 1 hit
3.40.220.10, 1 hit
3.90.70.90, 2 hits
InterProiView protein in InterPro
IPR022570, B-CoV_NSP1
IPR043613, CoV_NSP2_C
IPR043611, CoV_NSP3_C
IPR043612, CoV_NSP4_N
IPR043610, CoV_NSP6
IPR002589, Macro_dom
IPR043472, Macro_dom-like
IPR036333, NSP10_sf_CoV
IPR032592, NSP3_NAR_bCoV
IPR038083, NSP3A-like
IPR032505, NSP4_C_CoV
IPR038123, NSP4_C_sf_CoV
IPR014828, NSP7_CoV
IPR037204, NSP7_sf_CoV
IPR014829, NSP8_CoV-like
IPR037230, NSP8_sf_CoV
IPR014822, NSP9_CoV
IPR036499, NSP9_sf_CoV
IPR002705, Pept_C30/C16_B_coronavir
IPR013016, Peptidase_C16_CoV
IPR008740, Peptidase_C30_CoV
IPR043477, Peptidase_C30_dom3_CoV
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR043177, PLpro_N_sf_CoV
IPR043503, PLpro_palm_finger_dom_CoV
IPR043178, PLpro_thumb_sf_CoV
IPR018995, RNA_synth_NSP10_CoV
PfamiView protein in Pfam
PF16251, bCoV_NAR, 1 hit
PF09401, CoV_NSP10, 1 hit
PF19212, CoV_NSP2_C, 1 hit
PF19218, CoV_NSP3_C, 1 hit
PF16348, CoV_NSP4_C, 1 hit
PF19217, CoV_NSP4_N, 1 hit
PF19213, CoV_NSP6, 1 hit
PF08716, CoV_NSP7, 1 hit
PF08717, CoV_NSP8, 1 hit
PF08710, CoV_NSP9, 1 hit
PF08715, CoV_peptidase, 1 hit
PF11963, DUF3477, 1 hit
PF01661, Macro, 1 hit
PF01831, Peptidase_C16, 1 hit
PF05409, Peptidase_C30, 1 hit
SMARTiView protein in SMART
SM00506, A1pp, 1 hit
SUPFAMiSSF101816, SSF101816, 1 hit
SSF140367, SSF140367, 1 hit
SSF143076, SSF143076, 1 hit
SSF144246, SSF144246, 1 hit
SSF159936, SSF159936, 1 hit
SSF50494, SSF50494, 1 hit
SSF52949, SSF52949, 1 hit
PROSITEiView protein in PROSITE
PS51442, M_PRO, 1 hit
PS51154, MACRO, 1 hit
PS51124, PEPTIDASE_C16, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiU3N895_CVHK1
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: U3N895
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 11, 2013
Last sequence update: December 11, 2013
Last modified: December 2, 2020
This is version 43 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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