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Protein
Submitted name:

Ubiquitin-conjugating enzyme E2 R1

Gene

CDC34

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei37Glycyl thioester intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Biological processUbl conjugation pathwayUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Ubiquitin-conjugating enzyme E2 R1Imported
Gene namesi
Name:CDC34Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000099804.8
HGNCiHGNC:1734 CDC34

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000099804

PTM / Processingi

Proteomic databases

PeptideAtlasiU3KQP9
PRIDEiU3KQP9

Expressioni

Gene expression databases

BgeeiENSG00000099804 Expressed in 214 organ(s), highest expression level in testis
ExpressionAtlasiU3KQP9 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliU3KQP9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 91UBIQUITIN_CONJUGAT_2InterPro annotationAdd BLAST91

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00730000110436

Family and domain databases

Gene3Di3.10.110.10, 1 hit
InterProiView protein in InterPro
IPR000608 UBQ-conjugat_E2
IPR023313 UBQ-conjugating_AS
IPR016135 UBQ-conjugating_enzyme/RWD
PfamiView protein in Pfam
PF00179 UQ_con, 1 hit
SUPFAMiSSF54495 SSF54495, 1 hit
PROSITEiView protein in PROSITE
PS00183 UBIQUITIN_CONJUGAT_1, 1 hit
PS50127 UBIQUITIN_CONJUGAT_2, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

U3KQP9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
YFKARLKFPI DYPYSPPAFR FLTKMWHPNI YETGDVCISI LHPPVDAERD
60 70 80 90 100
GVKVPTTLAE YCVKTKAPAP DEGSDLFYDD YYEDGEVEEE ADSCFGDDED

DSGTEES
Length:107
Mass (Da):12,173
Last modified:October 29, 2014 - v2
Checksum:i783B5CABC2FDB8A4
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P49427UB2R1_HUMAN
Ubiquitin-conjugating enzyme E2 R1
CDC34 UBCH3, UBE2R1
236Annotation score:
U3KQ77U3KQ77_HUMAN
Ubiquitin-conjugating enzyme E2 R1
CDC34
119Annotation score:
U3KPV8U3KPV8_HUMAN
Ubiquitin-conjugating enzyme E2 R1
CDC34
146Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011531 Genomic DNA No translation available.
AC011556 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000607527; ENSP00000476107; ENSG00000099804
UCSCiuc060qop.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011531 Genomic DNA No translation available.
AC011556 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliU3KQP9
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiU3KQP9
PRIDEiU3KQP9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000607527; ENSP00000476107; ENSG00000099804
UCSCiuc060qop.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000099804.8
HGNCiHGNC:1734 CDC34
OpenTargetsiENSG00000099804
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00730000110436

Miscellaneous databases

ChiTaRSiCDC34 human

Gene expression databases

BgeeiENSG00000099804 Expressed in 214 organ(s), highest expression level in testis
ExpressionAtlasiU3KQP9 baseline and differential

Family and domain databases

Gene3Di3.10.110.10, 1 hit
InterProiView protein in InterPro
IPR000608 UBQ-conjugat_E2
IPR023313 UBQ-conjugating_AS
IPR016135 UBQ-conjugating_enzyme/RWD
PfamiView protein in Pfam
PF00179 UQ_con, 1 hit
SUPFAMiSSF54495 SSF54495, 1 hit
PROSITEiView protein in PROSITE
PS00183 UBIQUITIN_CONJUGAT_1, 1 hit
PS50127 UBIQUITIN_CONJUGAT_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiU3KQP9_HUMAN
AccessioniPrimary (citable) accession number: U3KQP9
Entry historyiIntegrated into UniProtKB/TrEMBL: November 13, 2013
Last sequence update: October 29, 2014
Last modified: September 12, 2018
This is version 34 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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