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Protein
Submitted name:

Calpain small subunit 1

Gene

CAPNS1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi84 – 95PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi114 – 125PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

Keywordsi

LigandCalciumPROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Calpain small subunit 1Imported
Gene namesi
Name:CAPNS1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000126247.10
HGNCiHGNC:1481 CAPNS1

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000126247

PTM / Processingi

Proteomic databases

MaxQBiU3KQE2
PeptideAtlasiU3KQE2
PRIDEiU3KQE2

Expressioni

Gene expression databases

BgeeiENSG00000126247 Expressed in 235 organ(s), highest expression level in adult mammalian kidney
ExpressionAtlasiU3KQE2 baseline and differential

Structurei

3D structure databases

SMRiU3KQE2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini71 – 99EF-handInterPro annotationAdd BLAST29
Domaini101 – 136EF-handInterPro annotationAdd BLAST36

Phylogenomic databases

eggNOGiKOG0037 Eukaryota
ENOG410YKQK LUCA
GeneTreeiENSGT00620000087734

Family and domain databases

InterProiView protein in InterPro
IPR029642 CAPN4
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
PANTHERiPTHR44408:SF3 PTHR44408:SF3, 1 hit
PfamiView protein in Pfam
PF13833 EF-hand_8, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 2 hits

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 11 potential isoforms that are computationally mapped.Show allAlign All

U3KQE2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGEAAAQYNP EPPPPRTHYS NIEANESEEV RQFRRLFAQL AGDDMEVSAT
60 70 80 90 100
ELMNILNKVV TRHPDLKTDG FGIDTCRSMV AVMDSDTTGK LGFEEFKYLW
110 120 130 140 150
NNIKRWQAIY KQFDTDRSGT ICSSELPGAF EAAGFHLNEH LYNMIIRRYS
160
DESGNMDFDN F
Length:161
Mass (Da):18,446
Last modified:November 13, 2013 - v1
Checksum:iAC7182BCBE52246B
GO

Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P04632CPNS1_HUMAN
Calpain small subunit 1
CAPNS1 CAPN4, CAPNS
268Annotation score:
A0A075B7C0A0A075B7C0_HUMAN
Calpain small subunit 1
CAPNS1
197Annotation score:
A0A0C4DGQ5A0A0C4DGQ5_HUMAN
Calpain small subunit 1
CAPNS1
322Annotation score:
K7ELJ7K7ELJ7_HUMAN
Calpain small subunit 1
CAPNS1
278Annotation score:
K7EIV0K7EIV0_HUMAN
Calpain small subunit 1
CAPNS1
196Annotation score:
K7EKD8K7EKD8_HUMAN
Calpain small subunit 1
CAPNS1
238Annotation score:
U3KPR7U3KPR7_HUMAN
Calpain small subunit 1
CAPNS1
100Annotation score:
K7EM73K7EM73_HUMAN
Calpain small subunit 1
CAPNS1
163Annotation score:
K7EMQ1K7EMQ1_HUMAN
Calpain small subunit 1
CAPNS1
94Annotation score:
K7ES78K7ES78_HUMAN
Calpain small subunit 1
CAPNS1
72Annotation score:
There is more potential isoformShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei161Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AD001527 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000586963; ENSP00000475804; ENSG00000126247
UCSCiuc060xns.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AD001527 Genomic DNA No translation available.

3D structure databases

SMRiU3KQE2
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiU3KQE2
PeptideAtlasiU3KQE2
PRIDEiU3KQE2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000586963; ENSP00000475804; ENSG00000126247
UCSCiuc060xns.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000126247.10
HGNCiHGNC:1481 CAPNS1
OpenTargetsiENSG00000126247
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0037 Eukaryota
ENOG410YKQK LUCA
GeneTreeiENSGT00620000087734

Miscellaneous databases

ChiTaRSiCAPNS1 human

Gene expression databases

BgeeiENSG00000126247 Expressed in 235 organ(s), highest expression level in adult mammalian kidney
ExpressionAtlasiU3KQE2 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR029642 CAPN4
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
PANTHERiPTHR44408:SF3 PTHR44408:SF3, 1 hit
PfamiView protein in Pfam
PF13833 EF-hand_8, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiU3KQE2_HUMAN
AccessioniPrimary (citable) accession number: U3KQE2
Entry historyiIntegrated into UniProtKB/TrEMBL: November 13, 2013
Last sequence update: November 13, 2013
Last modified: September 12, 2018
This is version 38 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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