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UniProtKB - U3KQB3 (U3KQB3_HUMAN)
Protein
Non-specific serine/threonine protein kinase
Gene
CSNK1G1
Organism
Homo sapiens (Human)
Status
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 73 | ATPPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-UniRule
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- protein serine/threonine kinase activity Source: UniProtKB-KW
- protein serine kinase activity Source: RHEA
GO - Biological processi
- Wnt signaling pathway Source: UniProtKB-KW
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinaseUniRule annotation, Transferase |
Biological process | Wnt signaling pathwayARBA annotation |
Ligand | ATP-bindingPROSITE-ProRule annotationARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Non-specific serine/threonine protein kinaseARBA annotation (EC:2.7.11.1ARBA annotation) |
Gene namesi | Name:CSNK1G1Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:2454, CSNK1G1 |
VEuPathDBi | HostDB:ENSG00000169118 |
Expressioni
Gene expression databases
Bgeei | ENSG00000169118, Expressed in secondary oocyte and 222 other tissues |
ExpressionAtlasi | U3KQB3, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 44 – 315 | Protein kinaseInterPro annotationAdd BLAST | 272 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 36 | DisorderedSequence analysisAdd BLAST | 36 | |
Regioni | 351 – 384 | DisorderedSequence analysisAdd BLAST | 34 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 17 | Basic and acidic residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 18 – 36 | Polar residuesSequence analysisAdd BLAST | 19 | |
Compositional biasi | 362 – 384 | Polar residuesSequence analysisAdd BLAST | 23 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.ARBA annotation
Phylogenomic databases
GeneTreei | ENSGT00940000155628 |
OrthoDBi | 889559at2759 |
PhylomeDBi | U3KQB3 |
Family and domain databases
InterProi | View protein in InterPro IPR022247, Casein_kinase-1_gamma_C IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF12605, CK1gamma_C, 1 hit PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 14 potential isoforms that are computationally mapped.Show allAlign All
U3KQB3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDHPSREKDE RQRTTKPMAQ RSAHCSRPSG SSSSSGVLMV GPNFRVGKKI
60 70 80 90 100
GCGNFGELRL GKNLYTNEYV AIKLEPIKSR APQLHLEYRF YKQLGSAGEG
110 120 130 140 150
LPQVYYFGPC GKYNAMVLEL LGPSLEDLFD LCDRTFTLKT VLMIAIQLLS
160 170 180 190 200
RMEYVHSKNL IYRDVKPENF LIGRQGNKKE HVIHIIDFGL AKEYIDPETK
210 220 230 240 250
KHIPYREHKS LTGTARYMSI NTHLGKEQSR RDDLEALGHM FMYFLRGSLP
260 270 280 290 300
WQGLKADTLK ERYQKIGDTK RNTPIEALCE NFPEEMATYL RYVRRLDFFE
310 320 330 340 350
KPDYEYLRTL FTDLFEKKGY TFDYAYDWVG RPIPTPVGSV HVDSGASAIT
360 370 380 390 400
RESHTHRDRP SQQQPLRNQN VSSERRGEWE IQPSRQTNTS YLTSHLAADR
410 420 430 440 450
HGGSVQVVSS TNGELNVDDP TGAHSNAPIT AHAEVEVVEE AKCIMFHKPW
460 470
HWSQSSAVKM KFVVFLNMNV NFKCI
Computationally mapped potential isoform sequencesi
There are 14 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ9HCP0 | KC1G1_HUMAN | Casein kinase I isoform gamma-1 | CSNK1G1 | 422 | Annotation score: | ||
Q8IXA3 | Q8IXA3_HUMAN | Non-specific serine/threonine prote... | CSNK1G1 hCG_2004507 | 438 | Annotation score: | ||
A0A0U1RQT7 | A0A0U1RQT7_HUMAN | Non-specific serine/threonine prote... | CSNK1G1 | 430 | Annotation score: | ||
U3KQA5 | U3KQA5_HUMAN | Non-specific serine/threonine prote... | CSNK1G1 | 422 | Annotation score: | ||
A0A0U1RQY7 | A0A0U1RQY7_HUMAN | Non-specific serine/threonine prote... | CSNK1G1 | 459 | Annotation score: | ||
A0A0U1RR31 | A0A0U1RR31_HUMAN | Non-specific serine/threonine prote... | CSNK1G1 | 158 | Annotation score: | ||
A0A0U1RQK6 | A0A0U1RQK6_HUMAN | Non-specific serine/threonine prote... | CSNK1G1 | 204 | Annotation score: | ||
A0A0U1RQG9 | A0A0U1RQG9_HUMAN | Non-specific serine/threonine prote... | CSNK1G1 | 173 | Annotation score: | ||
A0A0U1RQN5 | A0A0U1RQN5_HUMAN | Non-specific serine/threonine prote... | CSNK1G1 | 67 | Annotation score: | ||
A0A0U1RR14 | A0A0U1RR14_HUMAN | Casein kinase I isoform gamma-1 | CSNK1G1 | 183 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC087632 Genomic DNA No translation available. AC100840 Genomic DNA No translation available. AC110054 Genomic DNA No translation available. KF456070 Genomic DNA No translation available. KF456071 Genomic DNA No translation available. |
RefSeqi | NP_001316534.1, NM_001329605.1 |
Genome annotation databases
Ensembli | ENST00000607537; ENSP00000475724; ENSG00000169118 |
GeneIDi | 53944 |
UCSCi | uc002anh.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC087632 Genomic DNA No translation available. AC100840 Genomic DNA No translation available. AC110054 Genomic DNA No translation available. KF456070 Genomic DNA No translation available. KF456071 Genomic DNA No translation available. |
RefSeqi | NP_001316534.1, NM_001329605.1 |
3D structure databases
SMRi | U3KQB3 |
ModBasei | Search... |
Proteomic databases
MaxQBi | U3KQB3 |
PRIDEi | U3KQB3 |
Protocols and materials databases
Antibodypediai | 13388, 422 antibodies from 32 providers |
DNASUi | 53944 |
Genome annotation databases
Ensembli | ENST00000607537; ENSP00000475724; ENSG00000169118 |
GeneIDi | 53944 |
UCSCi | uc002anh.2, human |
Organism-specific databases
CTDi | 53944 |
HGNCi | HGNC:2454, CSNK1G1 |
OpenTargetsi | ENSG00000169118 |
VEuPathDBi | HostDB:ENSG00000169118 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000155628 |
OrthoDBi | 889559at2759 |
PhylomeDBi | U3KQB3 |
Miscellaneous databases
BioGRID-ORCSi | 53944, 4 hits in 1077 CRISPR screens |
ChiTaRSi | CSNK1G1, human |
GenomeRNAii | 53944 |
Gene expression databases
Bgeei | ENSG00000169118, Expressed in secondary oocyte and 222 other tissues |
ExpressionAtlasi | U3KQB3, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR022247, Casein_kinase-1_gamma_C IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF12605, CK1gamma_C, 1 hit PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | U3KQB3_HUMAN | |
Accessioni | U3KQB3Primary (citable) accession number: U3KQB3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 13, 2013 |
Last sequence update: | November 13, 2013 | |
Last modified: | January 19, 2022 | |
This is version 54 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |