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Protein
Submitted name:

N-terminal EF-hand calcium-binding protein 3

Gene

NECAB3

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi49 – 60PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

Keywordsi

LigandCalciumPROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
N-terminal EF-hand calcium-binding protein 3Imported
Gene namesi
Name:NECAB3Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000125967.16
HGNCiHGNC:15851 NECAB3

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000125967

PTM / Processingi

Proteomic databases

PeptideAtlasiU3KQ06

Expressioni

Gene expression databases

BgeeiENSG00000125967 Expressed in 214 organ(s), highest expression level in left adrenal gland
ExpressionAtlasiU3KQ06 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliU3KQ06
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 71EF-handInterPro annotationAdd BLAST36
Domaini238 – 297ABMInterPro annotationAdd BLAST60

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili221 – 248Sequence analysisAdd BLAST28

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

GeneTreeiENSGT00390000009734

Family and domain databases

InterProiView protein in InterPro
IPR007138 ABM_dom
IPR011008 Dimeric_a/b-barrel
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR039862 NECAB1/2/3
PANTHERiPTHR12178 PTHR12178, 2 hits
PfamiView protein in Pfam
PF13202 EF-hand_5, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
SSF54909 SSF54909, 1 hit
PROSITEiView protein in PROSITE
PS51725 ABM, 1 hit
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

U3KQ06-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MACAGLLTVC LLRPPAPQPQ PQTPRHPQLA PDPGPAGHTL FQDVFRRADK
60 70 80 90 100
NDDGKLSFEE FQNYFADGVL SLGELQELFS GIDGHLTDNL ETEKLCDYFS
110 120 130 140 150
EHLGVYRPVL AALESLNRAV LAAMDATKLE YERASKVDQF VTRFLLRETV
160 170 180 190 200
SQLQALQSSL EGASDTLEAQ AHGWRSDAES VEAQSRLCGS RRAGRRALRS
210 220 230 240 250
VSRSSTWSPG SSDTGRSSEA EMQWRLQVNR LQELIDQLEC KRQVQVAEEG
260 270 280 290
LQDFHRALRC YVDFTGAQSH CLHVSAQKML DGASFTLYEF WQDEASW
Length:297
Mass (Da):33,267
Last modified:November 13, 2013 - v1
Checksum:i328201ACC801FC69
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q96P71NECA3_HUMAN
N-terminal EF-hand calcium-binding ...
NECAB3 APBA2BP, NIP1, SYTIP2, XB51
396Annotation score:
X6RCW6X6RCW6_HUMAN
N-terminal EF-hand calcium-binding ...
NECAB3
289Annotation score:
U3KPZ3U3KPZ3_HUMAN
N-terminal EF-hand calcium-binding ...
NECAB3
192Annotation score:
U3KQM7U3KQM7_HUMAN
N-terminal EF-hand calcium-binding ...
NECAB3
210Annotation score:
U3KQF5U3KQF5_HUMAN
N-terminal EF-hand calcium-binding ...
NECAB3
125Annotation score:
U3KQJ7U3KQJ7_HUMAN
N-terminal EF-hand calcium-binding ...
NECAB3
54Annotation score:
U3KQR6U3KQR6_HUMAN
N-terminal EF-hand calcium-binding ...
NECAB3
95Annotation score:
U3KQC6U3KQC6_HUMAN
N-terminal EF-hand calcium-binding ...
NECAB3
71Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei297Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL121906 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000606690; ENSP00000475420; ENSG00000125967
UCSCiuc061whc.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL121906 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliU3KQ06
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiU3KQ06

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000606690; ENSP00000475420; ENSG00000125967
UCSCiuc061whc.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000125967.16
HGNCiHGNC:15851 NECAB3
OpenTargetsiENSG00000125967
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00390000009734

Miscellaneous databases

ChiTaRSiNECAB3 human

Gene expression databases

BgeeiENSG00000125967 Expressed in 214 organ(s), highest expression level in left adrenal gland
ExpressionAtlasiU3KQ06 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR007138 ABM_dom
IPR011008 Dimeric_a/b-barrel
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR039862 NECAB1/2/3
PANTHERiPTHR12178 PTHR12178, 2 hits
PfamiView protein in Pfam
PF13202 EF-hand_5, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
SSF54909 SSF54909, 1 hit
PROSITEiView protein in PROSITE
PS51725 ABM, 1 hit
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiU3KQ06_HUMAN
AccessioniPrimary (citable) accession number: U3KQ06
Entry historyiIntegrated into UniProtKB/TrEMBL: November 13, 2013
Last sequence update: November 13, 2013
Last modified: November 7, 2018
This is version 23 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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