UniProtKB - U3JAR6 (U3JAR6_DANRE)
Protein
Submitted name:
Actin filament-associated protein 1
Gene
afap1
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
GO - Molecular functioni
- SH2 domain binding Source: GO_Central
- SH3 domain binding Source: GO_Central
GO - Biological processi
- regulation of cytoskeleton organization Source: InterPro
- regulation of signal transduction Source: InterPro
Names & Taxonomyi
Protein namesi | Submitted name: Actin filament-associated protein 1Imported |
Gene namesi | Name:afap1Imported |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio)Imported |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-100316-6, afap1 |
Expressioni
Gene expression databases
Bgeei | ENSDARG00000055284, Expressed in swim bladder and 23 other tissues |
ExpressionAtlasi | U3JAR6, baseline |
Interactioni
GO - Molecular functioni
- SH2 domain binding Source: GO_Central
- SH3 domain binding Source: GO_Central
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000107378 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 156 – 252 | PHInterPro annotationAdd BLAST | 97 | |
Domaini | 347 – 441 | PHInterPro annotationAdd BLAST | 95 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 119 – 138 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 279 – 317 | DisorderedSequence analysisAdd BLAST | 39 | |
Regioni | 536 – 621 | DisorderedSequence analysisAdd BLAST | 86 | |
Regioni | 779 – 806 | DisorderedSequence analysisAdd BLAST | 28 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 633 – 718 | Sequence analysisAdd BLAST | 86 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 279 – 312 | PolyampholyteSequence analysisAdd BLAST | 34 | |
Compositional biasi | 550 – 590 | PolarSequence analysisAdd BLAST | 41 | |
Compositional biasi | 792 – 806 | PolyampholyteSequence analysisAdd BLAST | 15 |
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
eggNOGi | ENOG502QQI1, Eukaryota |
GeneTreei | ENSGT00950000183067 |
OMAi | SSNHYKH |
OrthoDBi | 256810at2759 |
Family and domain databases
Gene3Di | 2.30.29.30, 2 hits |
InterProi | View protein in InterPro IPR030113, AFAP IPR029907, AFAP-110 IPR011993, PH-like_dom_sf IPR001849, PH_domain |
PANTHERi | PTHR14338, PTHR14338, 1 hit PTHR14338:SF8, PTHR14338:SF8, 1 hit |
Pfami | View protein in Pfam PF00169, PH, 2 hits |
SMARTi | View protein in SMART SM00233, PH, 2 hits |
PROSITEi | View protein in PROSITE PS50003, PH_DOMAIN, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
U3JAR6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTESNEEAME ELLAELRVFL ELLDREYLTA GVREKKQQIL NILHRVLATR
60 70 80 90 100
EPSCKTEIHT SLPAPPQMPL PEIPHPWMPP DNGPPPLPSS SLPEGYYEEA
110 120 130 140 150
VPLGPGKAPE YITSNYDSDA MSSSYESYDE EEEDGKGQKM RHQWPSEEAS
160 170 180 190 200
MDLVKDARIC AFLLRKKRFG QWTKLLCVIK DNKLLCYKSS KDQTPQMELL
210 220 230 240 250
LSGCSITHIP KDGKKKKHEL KIVHQGADAL VLAVQSKEQA EQWLKVMKEV
260 270 280 290 300
CSNGNGVVDC DGAGSGSTVH KAELEKKLSC DRPSSDGEPC HENGISDGKD
310 320 330 340 350
PAKGKKNSKS EQKGTVGRVT GKKITKIISL GKKKPSTDEQ TSSAEEDVPT
360 370 380 390 400
CGYLNVLSNN RWRERWCQLK DNQLFLHKDR ADLKTHMASL PLRGCEVIPG
410 420 430 440 450
LDSKHPFAFR LLRNGQEVAV LEASSSESMG RWLGVLLAET GSTTDPAALH
460 470 480 490 500
YDYIDVETTA NVIQLAKQSF CFTSKRAVSP NPYLDNPVNG YACPTGVALH
510 520 530 540 550
YDDVPCINGT IPDAHYSSPA SGGRRWKDES HYENTDLYEN MPSPKLAARY
560 570 580 590 600
SPKSTRTSSS SGHYSTPNST KSLSSSSAAN TNTNQMKGKK GLITNGFGAK
610 620 630 640 650
KLDKNQPKKA NGISSTLPVK RNNSSVDQYK YGKNRVEADA KKLQAKEEEL
660 670 680 690 700
MRKKQEIRNR LTQLKKDRKD LRTALENNTA KRSQASLTER LKKVEDECKL
710 720 730 740 750
KEEERVSLEL ELTEVKESLK KALNGGVTLG LTIEPKTGSS SPQSPVLMRR
760 770 780 790 800
TVDNSPISSC NTSDTETCSL PVNSASLLRR QTQQKASPVR GHVLRKAKEW
EMKSGT
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE7F4D2 | E7F4D2_DANRE | Actin filament-associated protein 1 | afap1 | 776 | Annotation score: | ||
A0A2R8Q760 | A0A2R8Q760_DANRE | Actin filament-associated protein 1 | afap1 | 672 | Annotation score: | ||
A0A2R8RPV3 | A0A2R8RPV3_DANRE | Actin filament-associated protein 1 | afap1 | 717 | Annotation score: | ||
A0A2R8Q5J8 | A0A2R8Q5J8_DANRE | Actin filament-associated protein 1 | afap1 | 289 | Annotation score: | ||
A0A2R8QP26 | A0A2R8QP26_DANRE | Actin filament-associated protein 1 | afap1 | 213 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX465854 Genomic DNA No translation available. |
RefSeqi | XP_696774.4, XM_691682.6 |
Genome annotation databases
Ensembli | ENSDART00000153199; ENSDARP00000127335; ENSDARG00000055284 |
GeneIDi | 568356 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX465854 Genomic DNA No translation available. |
RefSeqi | XP_696774.4, XM_691682.6 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000107378 |
Proteomic databases
PaxDbi | U3JAR6 |
Genome annotation databases
Ensembli | ENSDART00000153199; ENSDARP00000127335; ENSDARG00000055284 |
GeneIDi | 568356 |
Organism-specific databases
CTDi | 60312 |
ZFINi | ZDB-GENE-100316-6, afap1 |
Phylogenomic databases
eggNOGi | ENOG502QQI1, Eukaryota |
GeneTreei | ENSGT00950000183067 |
OMAi | SSNHYKH |
OrthoDBi | 256810at2759 |
Gene expression databases
Bgeei | ENSDARG00000055284, Expressed in swim bladder and 23 other tissues |
ExpressionAtlasi | U3JAR6, baseline |
Family and domain databases
Gene3Di | 2.30.29.30, 2 hits |
InterProi | View protein in InterPro IPR030113, AFAP IPR029907, AFAP-110 IPR011993, PH-like_dom_sf IPR001849, PH_domain |
PANTHERi | PTHR14338, PTHR14338, 1 hit PTHR14338:SF8, PTHR14338:SF8, 1 hit |
Pfami | View protein in Pfam PF00169, PH, 2 hits |
SMARTi | View protein in SMART SM00233, PH, 2 hits |
PROSITEi | View protein in PROSITE PS50003, PH_DOMAIN, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | U3JAR6_DANRE | |
Accessioni | U3JAR6Primary (citable) accession number: U3JAR6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 13, 2013 |
Last sequence update: | November 13, 2013 | |
Last modified: | October 7, 2020 | |
This is version 42 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |